Jukka Jolkkonen
Tutkimusjohtaja
Lääketieteen laitos, Kliinisen lääketieteen yksikkö
jukka.jolkkonen@uef.fi | 040 355 2519
0403552519
040 3552519
040 355 2519
+358 40 355 2519
+35840 355 2519
040 3552 519
+358 40 3552 519
+35840 3552 519
+358 40 3552519
+35840 3552519
+358403552519
040 3552519
040 355 2519
+358 40 355 2519
+35840 355 2519
040 3552 519
+358 40 3552 519
+35840 3552 519
+358 40 3552519
+35840 3552519
+358403552519
Tutkimusryhmät
Julkaisut
147 kappaletta-
Dynamic release of neuronal extracellular vesicles containing miR‐21a‐5p is induced by hypoxia
Korvenlaita, Nea; Gómez‐Budia, Mireia; Scoyni, Flavia; Pistono, Cristiana; Giudice, Luca; Eamen, Shaila; Loppi, Sanna; de Sande, Ana Hernández; Huremagic, Benjamin; Bouvy‐Liivrand, Maria; Heinäniemi, Merja; Kaikkonen, Minna U.; Cheng, Lesley; Hill, Andrew F.; Kanninen, Katja M.; Jenster, Guido W.; van Royen, Martin E.; Ramiro, Laura; Montaner, Joan; Batkova, Tereza; Mikulik, Robert; Giugno, Rosalba; Jolkkonen, Jukka; Korhonen, Paula; Malm, Tarja. 2023. Journal of extracellular vesicles. 12: -
Editorial: Common and distinct mechanisms of migraine and stroke
Giniatullin, Rashid; Khazipov, Roustem; van den Maagdenberg, Arn M. J. M.; Jolkkonen, Jukka. 2023. Frontiers in cellular neuroscience. 17: . 1171836 -
Activation of Meningeal Afferents Relevant to Trigeminal Headache Pain after Photothrombotic Stroke Lesion: A Pilot Study in Mice
Krivoshein, Georgii; Bakreen, Abdulhameed; van den Maagdenberg, Arn MJM; Malm, Tarja; Giniatullin, Rashid; Jolkkonen, Jukka. 2022. International journal of molecular sciences. 23: -
Astrocyte Progenitors Derived From Patients With Alzheimer Disease Do Not Impair Stroke Recovery in Mice
Välimäki, Nelli-Noora; Bakreen, Abdulhameed; Häkli, Sara; Dhungana, Hiramani; Keuters, Meike H; Dunlop, Yannick; Koskuvi, Marja; Keksa-Goldsteine, Velta; Oksanen, Minna; Jäntti, Henna; Lehtonen, Šárka; Malm, Tarja; Koistinaho, Jari; Jolkkonen, Jukka. 2022. Stroke. 53: 3192-3201 -
Impact of drug treatment and drug interactions in post-stroke epilepsy
Zhao, Lanqing; Li, Jinwei; Kälviäinen, Reetta; Jolkkonen, Jukka; Zhao, Chuansheng. 2022. Pharmacology and therapeutics. 233: -
Long-term modification of gut microbiota by broad-spectrum antibiotics improves stroke outcome in rats
Liu, Chang; Cheng, Xi; Zhong, Shanshan; Liu, Zhouyang; Liu, Fangxi; Lin, Xinyu; Zhao, Yinan; Guan, Meiting; Xiao, Ting; Jolkkonen, Jukka; Wang, Ying; Zhao, Chuansheng. 2022. Stroke and vascular neurology. 7: 381-389 -
Perioperative stroke: A perspective on challenges and opportunities for experimental treatment and diagnostic strategies
Jin, Xia; Li, Peiying; Michalski, Dominik; Li, Shen; Zhang, Yueman; Jolkkonen, Jukka; Cui, Lili; Didwischus, Nadine; Xuan, Wei; Boltze, Johannes. 2022. Cns neuroscience and therapeutics. 28: 497-509 -
Prognostic Signature for Human Umbilical Cord Mesenchymal Stem Cell Treatment of Ischemic Cerebral Infarction by Integrated Bioinformatic Analysis
Wen, Zhifeng; Liu, Fangxi; Lin, Xinyu; Zhong, Shanshan; Zhang, Xiuchun; Zhou, Zhike; Jolkkonen, Jukka; Liu, Chang; Zhao, Chuansheng. 2022. Biomed research international. 2022: -
Sex Differences in Poststroke Inflammation: a Focus on Microglia Across the Lifespan
Ugidos, Irene F; Pistono, Cristiana; Korhonen, Paula; Gómez-Budia, Mireia; Sitnikova, Valeriia; Klecki, Pamela; Stanová, Iveta; Jolkkonen, Jukka; Malm, Tarja. 2022. Stroke. 53: 1500-1509 -
Additive Behavioral Improvement after Combined Cell Therapy and Rehabilitation Despite Long-Term Microglia Presence in Stroke Rats
Bakreen, Abdulhameed; Juntunen, Miia; Dunlop, Yannick; Ugidos, Irene F.; Malm, Tarja; Miettinen, Susanna; Jolkkonen, Jukka. 2021. International journal of molecular sciences. 22: 1512 -
New Mechanistic Insights, Novel Treatment Paradigms, and Clinical Progress in Cerebrovascular Diseases
Boltze, Johannes; Aronowski, Jaroslaw A; Badaut, Jerome; Buckwalter, Marion S; Caleo, Mateo; Chopp, Michael; Dave, Kunjan R; Didwischus, Nadine; Dijkhuizen, Rick M; Doeppner, Thorsten R; Dreier, Jens P; Fouad, Karim; Gelderblom, Mathias; Gertz, Karen; Golubczyk, Dominika; Gregson, Barbara A; Hamel, Edith; Hanley, Daniel F; Haertig, Wolfgang; Hummel, Friedhelm C et al. (Incl. Jolkkonen, Jukka). 2021. Frontiers in aging neuroscience. 13: 623751 -
Blood-based Biomarkers and Stem Cell Therapy in Human Stroke: A Systematic Review
Palà, Elena; Bustamante, Alejandro; Jolkkonen, Jukka; Hommel, Marc; Rosell, Anna; Montaner, Joan. 2020. Molecular biology reports. 47: 6247-6258 -
Communications Between Peripheral and the Brain-Resident Immune System in Neuronal Regeneration After Stroke
Liu, Fangxi; Cheng, Xi; Zhong, Shanshan; Liu, Chang; Jolkkonen, Jukka; Zhang, Xiuchun; Liang, Yifan; Liu, Zhouyang; Zhao, Chuansheng. 2020. Frontiers in immunology. 11: 1-14 -
Hypoxia and extracellular vesicles: A review on methods, vesicular cargo and functions
Bister, Nea; Pistono, Cristiana; Huremagic, Benjamin; Jolkkonen, Jukka; Giugno, Rosalba; Malm, Tarja. 2020. Journal of extracellular vesicles. 10: e12002 -
Increased migratory and homing abilities of neural and mesenchymal stem cell populations by transient cell modifications: Preclinical progress and clinical relevance
Boltze, Johannes; Didwischus, Nadine; Li, Shen; Jolkkonen, Jukka; Taguchi, Akihiko. 2020. EBioMedicine. 60: 103022 -
Neurorepair Strategies After Stroke
Zhao, Chuansheng; Jolkkonen, Jukka. Teoksessa: Lee, Seung-Hoon(toim.) , 2020. Stroke Revisited: Pathophysiology of Stroke. From Bench to Bedside. s. 281-291. Springer -
Neurotropism of SARS-CoV-2 and its neuropathological alterations: Similarities with other coronaviruses
Hu, Jingman; Jolkkonen, Jukka; Zhao, Chuansheng. 2020. Neuroscience and biobehavioral reviews. 119: 184-193 -
8th Kuopio Stroke Symposium: A Global Action Against Stroke: Kuopio, Finland, June 5-7, 2019: Program and Abstracts
Jolkkonen, Jukka. 2019. Publications of the University of Eastern Finland. Reports and studies in health sciences. . Itä-Suomen yliopisto -
Cell therapy for ischemic stroke: are differences in preclinical and clinical study design responsible for the translational loss of efficacy?
Cui, LL; Golubczyk, D; Tolppanen, AM; Boltze, J; Jolkkonen, J. 2019. Annals of neurology. 86: 5-16 -
Combined Adipose Tissue-Derived Mesenchymal Stem Cell Therapy and Rehabilitation in Experimental Stroke
Mu, Jingwei; Bakreen, Abdulhameed; Juntunen, Miia; Korhonen, Paula; Oinonen, Ella; Cui, Lili; Myllyniemi, Mikko; Zhao, Shanshan; Miettinen, Susanna; Jolkkonen, Jukka. 2019. Frontiers in neurology. 10: 235 -
Effects of CXCR7-neutralizing antibody on neurogenesis in the hippocampal dentate gyrus and cognitive function in the chronic phase of cerebral ischemia
Dong, BC; Li, MX; Wang, XY; Cheng, X; Wang, Y; Xiao, T; Jolkkonen, J; Zhao, CS; Zhao, SS. 2019. Neural regeneration research. 2020; 15: 1079-1085 -
Intravenous delivery of adipose tissue-derived mesenchymal stem cells improves brain repair in hyperglycemic stroke rats
Gómez-de Frutos, MC; Laso-García, F; Diekhorst, L; Otero-Ortega, L; Fuentes, B; Jolkkonen, J; Detante, O; Moisan, A; Martínez-Arroyo, A; Díez-Tejedor, E; Gutiérrez-Fernández, M. 2019. Stem cell research & therapy. 10: 212 -
Mesenchymal Stem Cells From Adipose Tissue Do not Improve Functional Recovery After Ischemic Stroke in Hypertensive Rats
Diekhorst, L; Gómez-de Frutos, MC; Laso-García, F; Otero-Ortega, L; Fuentes, B; Jolkkonen, J; Detante, O; Moisan, A; Leyva, L; Martínez-Arroyo, A; Díez-Tejedor, E; Gutiérrez-Fernández, M; on behalf of RESSTORE Consortium. 2019. Stroke. 2020; 51: 342-346 -
Safety evaluation of intra-arterial cell delivery in stroke patients'a framework for future trials
Boltze, Johannes; Jolkkonen, Jukka. 2019. Annals of translational medicine. 7: S271 -
Stem Cells as an Emerging Paradigm in Stroke 4: Advancing and Accelerating Preclinical Research
Boltze, J; Modo, MM; Mays, RW; Taguchi, A; Jolkkonen, J; Savitz, SI. 2019. Stroke. 50: 3299-3306 -
Behavioral outcome measures to improve experimental stroke research
Balkaya, Mustafa G; Trueman, Rebecca C; Boltze, Johannes; Corbett, Dale; Jolkkonen, Jukka. 2018. Behavioural brain research. 352: 161-171 -
Future of Animal Modeling for Poststroke Tissue Repair
Modo, MM; Jolkkonen, J; Zille, M; Boltze, J. 2018. Stroke. 49: 1099-1106 -
Intravascular cell therapy in stroke: predicting the future trends
Cui, Lili; Moisan, Anaick; Jolkkonen, Jukka. 2018. Regenerative medicine. 2019; 14: 63-68 -
Translating experimental evidence to finding novel ways to promote motor recovery in stroke patients - a review
Zhao, Chuansheng; Könönen, Mervi; Vanninen, Ritva; Pitkänen, Kauko; Hiekkala, Sinikka; Jolkkonen, Jukka. 2018. Restorative neurology and neuroscience. 36: 519-533 -
Aivoverenkiertohäiriöt ja diabetes - mitä uutta?
Pitkänen Kauko, Jäkälä Pekka, Jolkkonen Jukka. 2017. BestPractice: Diabetes ja sydänsairaudet. 5: 8-10 -
Cell Therapy in Stroke - Cautious Steps Towards a Clinical Treatment
Detante Olivier, Muir Keith, Jolkkonen Jukka. 2017. Translational stroke research. [Epub 2017 Nov 17]: 1-12 -
Concise Review: Increasing the Validity of Cerebrovascular Disease Models and Experimental Methods for Translational Stem Cell Research
Boltze J, Nitzsche F, Jolkkonen J, Weise G, Posel C, Nitzsche B, Wagner DC. 2017. Stem cells. 35: 1141-1153 -
Concise Review: MSC Adhesion Cascade-Insights into Homing and Transendothelial Migration
Nitzsche F, Muller C, Lukomska B, Jolkkonen J, Deten A, Boltze J. 2017. Stem cells. 35: 1446-1460 -
Enhancing the Alignment of the Preclinical and Clinical Stroke Recovery Research Pipeline: Consensus-Based Core Recommendations From the Stroke Recovery and Rehabilitation Roundtable Translational Working Group
Corbett Dale, Carmichael S Thomas, Murphy Timothy H, Jones Theresa A, Schwab Martin E, Jolkkonen Jukka, Clarkson Andrew N, Dancause Numa, Weiloch Tadeusz, Johansen-Berg Heidi, Nilsson Michael, McCullough Louise D, Joy Mary T. 2017. Neurorehabilitation and neural repair. 31: 699-707 -
Enhancing the alignment of the preclinical and clinical stroke recovery research pipeline: Consensus-based core recommendations from the Stroke Recovery and Rehabilitation Roundtable translational working group
Corbett Dale, Carmichael S Thomas, Murphy Timothy H, Jones Theresa A, Schwab Martin E, Jolkkonen Jukka, Clarkson Andrew N, Dancause Numa, Weiloch Tadeusz, Johansen-Berg Heidi, Nilsson Michael, McCullough Louise D, Joy Mary T. 2017. International journal of stroke. 12: 462-471 -
Inhibition of Nkcc1 Promotes Axonal Growth and Motor Recovery in Ischemic Rats
Mu XP, Wang HB, Cheng X, Yang L, Sun XY, Qu HL, Zhao SS, Zhou ZK, Liu TT, Xiao T, Song B, Jolkkonen J, Zhao CS. 2017. Neuroscience. 365: 83-93 -
Integrin [alpha]4 Overexpression on Rat Mesenchymal Stem Cells Enhances Transmigration and Reduces Cerebral Embolism After Intracarotid Injection
Cui LL, Nitzsche F, Pryazhnikov E, Tibeykina M, Tolppanen L, Rytkönen J, Huhtala T, Mu JW, Khiroug L, Boltze J, Jolkkonen J. 2017. Stroke. 48: 2895-2900 -
Top 3 Behavioral Tests in Cell Therapy Studies After Stroke: Difficult to Stop a Moving Train
Cui LL, Golubczyk D, Jolkkonen J. 2017. Stroke. 48: 3165-3167 -
Translation, but not transfection limits clinically relevant, exogenous mRNA based induction of alpha-4 integrin expression on human mesenchymal stem cells
Nowakowski A, Andrzejewska A, Boltze J, Nitzsche F, Cui LL, Jolkkonen J, Walczak P, Lukomska B, Janowski M. 2017. Scientific reports. 7: 1103 -
7th Kuopio Stroke Symposium : From bench to bedside and back : Kuopio, Finland, June 8-10, 2016 : program and abstracts
Jolkkonen Jukka. 2016. Publications of the University of Eastern Finland. Reports and studies in health sciences. . Itä-Suomen yliopisto -
Chloride Co-transporter NKCC1 Inhibitor Bumetanide Enhances Neurogenesis and Behavioral Recovery in Rats After Experimental Stroke
Xu W, Mu X, Wang H, Song C, Ma W, Jolkkonen J, Zhao C. 2016. Molecular neurobiology. 54: 2406-2414 -
Clumping and Viability of Bone Marrow Derived
Cui Li-li, Kinnunen Tuure, Boltze Johannes, Nystedt Johanna, Jolkkonen Jukka. 2016. Stem cells international. 2016: 8 pages -
Increased protein expression levels of pCREB, BDNF and SDF-1/CXCR4 in the hippocampus may be associated with enhanced neurogenesis induced by environmental enrichment
Zhang Xiao Qian, Mu Jing Wei, Wang Hui Bin, Jolkkonen Jukka, Liu Ting Ting, Xiao Ting, Zhao Mei, Zhang Chao Dong, Zhao Chuan Sheng. 2016. Molecular medicine reports. 14: 2231-2237 -
The Current State of Cell Therapies for Cerebrovascular Diseases
Jolkkonen J, Mendez-Otero R, de Freitas GR, Boltze J, Rosado-de-Castro PH. 2016. Stem cells international. 2016: - -
Translational Hurdles in Stroke Recovery Studies
Jolkkonen Jukka, Kwakkel Gert. 2016. Translational stroke research. 7: 331-342 -
CXCR4 antagonist AMD3100 reverses the neurogenesis and behavioral recovery promoted by forced limb-use in stroke rats
Zhao S, Qu H, Zhao Y, Xiao T, Zhao M, Li Y, Jolkkonen J, Cao Y, Zhao C. 2015. Restorative neurology and neuroscience. 33: 809-821 -
Combined enriched environment/atipamezole treatment transiently improves sensory functions in stroke rats independent from neurogenesis and angiogenesis
Kuptsova Kristina, Kvist Elisabet, Nitzsche Franziska, Jolkkonen Jukka. 2015. Journal of Molecular and Cellular Pathology. 56: 41-47 -
Fluoxetine Enhances Neurogenesis in Aged Rats with Cortical Infarcts, but This is not Reflected in a Behavioral Recovery
Sun X, Zhou Z, Liu T, Zhao M, Zhao S, Xiao T, Jolkkonen J, Zhao C. 2015. Journal of molecular neuroscience. 2016; 58: 233-242 -
Fluoxetine enhanced neurogenesis is not translated to functional outcome in stroke rats
Sun X, Sun X, Liu T, Zhao M, Zhao S, Xiao T, Jolkkonen J, Zhao C. 2015. Neuroscience letters. 603: 31-36 -
Infarction of the Corpus Callosum : A Retrospective Clinical Investigation
Li Shen, Sun Xin, Bai Yu-meng, Qin Hua-min, Wu Xiao-mei, Zhang Xiao, Jolkkonen Jukka, Boltze Johannes, Wang Su-ping. 2015. PLoS ONE. 10: e0120409 -
Proper housing conditions in experimental stroke studies - special emphasis on environmental enrichment
Mering Satu, Jolkkonen Jukka. 2015. Frontiers in neuroscience. 9: 8 pages -
The cerebral embolism evoked by intra-arterial delivery of allogeneic bone marrow mesenchymal stem cells in rats is related to cell dose and infusion velocity
Cui Li-Li, Kerkelä Erja, Bakreen Abdulhameed, Nitzsche Franziska, Andrzejewska Anna, Nowakowski Adam, Janowski Miroslaw, Walczak Piotr, Boltze Johannes, Lukomska Barbara, Jolkkonen Jukka. 2015. Stem cell research & therapy. 6: 9 pages -
The dark side of the force - constraints and complications of cell therapies for stroke
Boltze Johannes, Arnold Antje, Walczak Piotr, Jolkkonen Jukka, Cui Lili, Wagner Daniel-Christoph. 2015. Frontiers in neurology. 6: 155 -
The future of stem cell therapy for stroke rehabilitation
Borlongan Cesar V, Jolkkonen Jukka, Detante Olivier. 2015. Future neurology. 10: 313-319 -
Unexpected complication in a rat stroke model: exacerbation of secondary pathology in the thalamus by subacute intraarterial administration of human bone marrow-derived mesenchymal stem cells
Mitkari Bhimashankar, Kerkelä Erja, Nystedt Johanna, Korhonen Matti, Jolkkonen Jukka. 2015. Journal of cerebral blood flow and metabolism. 35: 363-366 -
Differential Clearance of Rat and Human Bone Marrow-Derived Mesenchymal Stem Cells from the Brain After Intra-arterial Infusion in Rats
Khabbal J, Kerkelä E, Mitkari B, Raki M, Nystedt J, Mikkonen V, Bergström K, Laitinen S, Korhonen M, Jolkkonen J. 2014. Cell transplantation. 2014: - -
Forced limb-use enhanced neurogenesis and behavioral recovery after stroke in the aged rats
Qu HL, Zhao M, Zhao SS, Xiao T, Song CG, Cao YP, Jolkkonen J, Zhao CS. 2014. Neuroscience. 2014: 1-8 -
Forced limb-use enhances brain plasticity through the cAMP/PKA/CREB signal transduction pathway after stroke in adult rats
Qu H, Zhao M, Zhao S, Xiao T, Tang X, Zhao D, Jolkkonen J, Zhao C. 2014. Restorative neurology and neuroscience. 32: 597-609 -
KB-R7943, an inhibitor of the reverse Na(+)/Ca(2+) exchanger, does not modify secondary pathology in the thalamus following focal cerebral stroke in rats
Lipsanen Anu, Parkkinen Saara, Khabbal Joonas, Mäkinen Petra, Peräniemi Sirpa, Hiltunen Mikko, Jolkkonen Jukka. 2014. Neuroscience letters. 580: 173-177 -
Mesenchymal stromal cells in stroke: improvement of motor recovery or functional compensation?
Boltze Johannes, Lukomska Barbara, Jolkkonen Jukka, MEMS-IRBI consortium, Collaborators:, Andrzejewska A, Cui L, Deten A, Nitzsche F, Nowakowski A, Wagner DC, Walczak P. 2014. Journal of cerebral blood flow and metabolism. 34: 1420-1421 -
Cell-Based Therapies in Stroke
Jolkkonen J, Walczak P. 2013. . . Springer -
Constraint-induced movement therapy overcomes the intrinsic axonal growth-inhibitory signals in stroke rats
Zhao S, Zhao M, Xiao T, Jolkkonen J, Zhao C. 2013. Stroke. 44: 1698-1705 -
Gait impairment in a rat model of focal cerebral ischemia
Parkkinen S, Ortega FJ, Kuptsova K, Huttunen J, Tarkka I, Jolkkonen J. 2013. Stroke research and treatment. -: 12 pages -
Human bone marrow mesenchymal stem/stromal cells produce efficient localization in the brain and enhanced angiogenesis after intra-arterial delivery in rats with cerebral ischemia, but this is not translated to behavioral recovery
Mitkari B, Nitzsche F, Kerkelä E, Kuptsova K, Huttunen J, Nystedt J, Korhonen M, Jolkkonen J. 2013. Behavioural brain research. -: - -
In Vivo Biodistribution Studies and Cell Tracking in Stroke Using SPECT Imaging
Baki M, Bergström K, Jolkkonen J. Teoksessa: Jolkkonen J, Walczak P(toim.) , 2013. Cell-Based Therapies in Stroke. s. 137-149. Springer -
Increased neurogenesis contributes to the promoted behavioral recovery by constraint-induced movement therapy after stroke in adult rats
Zhao S-S, Zhao Y, Xiao Y, Xiao T, Zhao M, Jolkkonen J, Zhan C-S. 2013. Cns neuroscience and therapeutics. 19: 194-196 -
Intra-arterial infusion of human bone marrow-derived mesenchymal stem cells results in transient localization in the brain after cerebral ischemia in rats
Mitkari B, Kerkelä E, Nystedt J, Korhonen M, Mikkonen V, Huhtala T, Jolkkonen J. 2013. Experimental neurology. 239: 158-162 -
Intravascular cell therapy in stroke patients: where the cells go and what they do
Korhonen M, Jolkkonen J. 2013. Regenerative medicine. 8: 93-95 -
Kuntoutumisen tehostamista lääkehoidolla
Jolkkonen J, Ortega FJ, Jäkälä P. 2013. Suomen aivotutkimus- ja kuntoutuskeskus Neuronin asiakaslehti. -: 8-10 -
Lack of secondary pathology in the thalamus after focal cerebral ischemia in nonhuman primates
Lipsanen A, Kalesnykas G, Pro-Sistiaga P, Hiltunen M, Vanninen R, Bernaudin M, Touzani O, Jolkkonen J. 2013. Experimental neurology. 248: 224-227 -
Microglia is an active player in how glibenclamide improves stroke outcome
Ortega FJ, Jolkkonen J, Rodriguez. 2013. Journal of cerebral blood flow and metabolism. 33: 1138-1139 -
Non-selective calcium channel blocker bepridil decreases secondary pathology in mice after photothrombotic cortical lesion
Lipsanen A, Flunkert S, Kuptsova K, Hiltunen M, Windisch M, Hutter-Paier B, Jolkkonen J. 2013. PLoS ONE. 8: e60235 -
Restorative therapies to enhance sensorimotor recovery following cerebral ischemia
Ortega FJ, Jolkkonen J. 2013. Acta neurobiologiae experimentalis. 73: 66-78 -
Stromal cell-derived factor-1 and its receptor CXCR4 in adult neurogenesis after cerebral ischemia
Cui L, Huiling Q, Xiao T, Zhao M, Jolkkonen J, Zhao C. 2013. Restorative neurology and neuroscience. 31: 239-251 -
Bepridil decreases Aβ and calcium levels in the thalamus after middle cerebral artery occlusion in rats
Sarajärvi Timo, Lipsanen Anu, Mäkinen Petra, Peräniemi Sirpa, Soininen Hilkka, Haapasalo Annakaisa, Jolkkonen Jukka, Hiltunen Mikko. 2012. Journal of cellular and molecular medicine. 16: 2754-2767 -
Glibenclamide enhances neurogenesis and improves long-term functional recovery after transient focal cerebral ischemia
Ortega FJ, Jolkkonen J, Mahy N, Rodriquez MJ. 2012. Journal of cerebral blood flow and metabolism. online: 1-9 -
Letter by Hiltunen and Jolkkonen Regarding Article, "Secondary Neurodegeneration in Remote Regions After Focal Cerebral Infarction: A New Target for Stroke Management?"
Hiltunen Mikko, Jolkkonen Jukka. 2012. Stroke. 43: e97 -
Secondary neurodegeneration in remote regions after focal cerebral infarction: A new target for Stroke Management
Hiltunen M, Jolkkonen J. 2012. Stroke. 43: e96 -
Time for a neurorestorative therapy in stroke
Jäkälä P, Jolkkonen J. 2012. Expert opinion on biological therapy. 12: 267-270 -
Toward a more effective intravascular cell therapy in stroke
Mitkari B, Kerkelä E, Nystedt J, Korhonen M, Huhtala T, Jolkkonen J. Teoksessa: Balestrino M(toim.) , 2012. Advances in the Treatment of Ischemic Stroke. s. 141-160. InTech -
Chronic hyperperfusion and angiogenesis follow subacute hypoperfusion in the thalamus of rats with focal cerebral ischemia
Hayward Nick MEA, Yanev Pavel, Haapasalo Annakaisa, Miettinen Riitta, Hiltunen Mikko, Gröhn Olli, Jolkkonen Jukka. 2011. Journal of cerebral blood flow and metabolism. 31: 1119-1132 -
Chronic ibuprofen treatment does not affect the secondary pathology in the thalamus or improve behavioral outcome in middle cerebral artery occlusion rats
Lipsanen Anu, Hiltunen Mikko, Jolkkonen Jukka. 2011. Pharmacology biochemistry and behavior. 99: 468-474 -
Cognitive impairment with vascular impairment and degeneration
Pluta R, Jolkkonen J, Cuzzocrea S, Pedata F, Cechetto D, Popa-Wagner A. 2011. Current neurovascular research. 8: 342-350 -
Complex pathology in the thalamus following cerebral ischemia
Hiltunen M, Jolkkonen J. Teoksessa: Song JL(toim.) , 2011. Thalamus: Anatomy, Functions and Disorders. s. 83-98. Nova science publishers -
Experimental approaches to study functional recovery following cerebral ischemia
Lipsanen Anu ja Jolkkonen Jukka. 2011. Cellular and molecular life sciences. 68: 3007-3017 -
Enhanced angiogenesis and reduced infarct size by vascular endothelial growth factor D is not translated to behavioral outcome in a rat model of ischemic stroke
Yanev P, Jolkkonen J, Airenne KJ, Ylä-Herttuala S & Wirth T. 2010. JOURNAL OF EXPERIMENTAL STROKE & TRANSLATIONAL MEDICINE. 3: 1-12 -
Cell-based therapies and functional outcome in experimental stroke
Hicks A, Schallert T, Jolkkonen J. 2009. Cell stem cell -
Challenges and possibilities of intravascular cell therapy in stroke
Hicks A, Jolkkonen J. 2009. Acta neurobiologiae experimentalis. 69: 1-10 -
Focal cerebral ischemia in rats alters APP processing and expression of Abeta peptide degrading enzymes in the thalamus
Hiltunen M, Mäkinen P, Peräniemi S, Sivenius J, van Groen T, Soininen H, Jolkkonen J, Hiltunen M, Sivenius J, Soininen H. 2009. Neurobiology of disease. 35: 103-113 -
Functional roles of amyloid-beta protein precursor and amyloid-beta peptides: Evidence from experimental studies
Hiltunen M, van Groen T, Jolkkonen J. 2009. Journal of Alzheimer's disease. 18: 401-412 -
Transplantation of human embryonic stem cell-derived neural precursor cells and enriched environment after cortical stroke in rats: cell survival and functional recovery
Hicks AU, Lappalainen RS, Narkilahti S, Suuronen R, Corbett D, Sivenius J, Hovatta O, Jolkkonen J, Sivenius J. 2009. European journal of neuroscience. 29: 562-574 -
CNS-active drugs in aging population at high risk of cerebrovascular events: Evidence from preclinical and clinical studies
Zhao CS, Hartikainen S, Schallert T, Sivenius J, Jolkkonen J, Sivenius J. 2008. Neuroscience and biobehavioral reviews. 32: 56-71 -
Coaccumulation of calcium and b-amyloid in the thalamus after transient middle cerebral artery occlusion in rats
Mäkinen S, van Groen T, Clarke J, Thornell A, Corbett D, Hiltunen M, Soininen H, Jolkkonen J, Hiltunen M, Soininen H. 2008. Journal of cerebral blood flow and metabolism. 28: 263-268 -
Improved sensorimotor function by rolipram following focal cerebral ischemia in rats
Hätinen S, Sairanen M, Sirviö J, Jolkkonen J. 2008. Restorative neurology and neuroscience. 26: 493-499 -
Neurodegeneration and cellular stress in the retina and optic nerve in rat cerebral ischemia and hypoperfusion models
Kalesnykas G, Tuulos T, Uusitalo H, Jolkkonen J. 2008. Neuroscience. 155: 937-947 -
The SPECT imaging shows the accumulation of neural progenitor cells into internal organs after systemic administration in middle cerebral artery occlusion rats
Lappalainen RS, Narkilahti S, Huhtala T, Liimatainen T, Suuronen T, Närvänen A, Suuronen R, Hovatta O, Jolkkonen J. 2008. Neuroscience letters. 440: 246-250 -
Enriched environment enhances transplanted subventricular zone stem cell migration and functional recovery after stroke
Hicks AU, Hewlett K, Windle V, Chernenko G, Ploughman M, Jolkkonen J, Weiss S, Corbett D. 2007. Neuroscience. 146: 31-40 -
Epileptogenesis after cortical photothrombotic brain lesion in rats
Karhunen H, Bezvenyuk Z, Nissinen J, Sivenius J, Jolkkonen J, Pitkänen A, Sivenius J. 2007. Neuroscience. 148: 314-324 -
Molecular mechanisms underlying neuroprotective effects of albumin after ischemic stroke
Parkkinen J, Ojala P, Niiranen J, Jolkkonen J. 2007. Stroke -
Overexpression of APP provides neuroprotection in the absence of functional benefit following middle cerebral artery occlusion in rats
Clarke J, Thornell A, Corbett D, Soininen H, Hiltunen M, Jolkkonen J, Soininen H. 2007. European journal of neuroscience. 26: 1845-1852 -
Subacute hemorrhage and resolution of edema in Rose Bengal stroke model in rats coincides with improved sensorimotor functions
Jolkkonen J, Jokivarsi K, Laitinen T, Gröhn O. 2007. Neuroscience letters. 428: 99-102 -
Thalamic calcification and amyloid deposition following focal cerebral ischemia in rats
Jolkkonen J, van Groen T. Teoksessa: Pluta R(toim.) , 2007. Ischemia-Reperfusion Pathways in Alzheimer's Disease. s. 99-111. Nova Science -
Transient occlusion of the middle cerebral artery in rats leads to permanent amyloid deposits in the thalamus
van Groen T, Kadish I, Jolkkonen J. Teoksessa: Pluta R(toim.) , 2007. Ischemia-Reperfusion Pathways in Alzheimer's Disease. s. 85-98. Nova Science -
A long-term video-EEG and behavioral follow-up after endothelin-1 induced middle cerebral artery occlusion in rats
Karhunen H, Nissinen J, Sivenius J, Jolkkonen J, Pitkänen A. 2006. Epilepsy research. 72: 25-38 -
Beta-amyloid aggregation in human brains with cerebrovascular lesions
Aho L, Jolkkonen J, Alafuzoff I. 2006. Stroke. 37: 2940-2945 -
Gene expression profiling in the hippocampus of rats subjected to focal cerebral ischemia and enriched environment housing
Sonninen R, Virtanen T, Sivenius J, Jolkkonen J. 2006. Restorative neurology and neuroscience. 24: 17-23 -
Human cord blood CD34+ cells and behavioral recovery following focal cerebral ischemia in rats
Nystedt J, Mäkinen S, Laine J, Jolkkonen J. 2006. Acta neurobiologiae experimentalis. 66: 293-300 -
Human umbilical cord blood cells do not improve sensorimotor of cognitive outcome following transient middle cerebral artery occlusion in rats
Mäkinen S, Kekarainen T, Nystedt J, Liimatainen T, Huhtala T, Närvänen A, Laine J, Jolkkonen J. 2006. Brain research. 1123: 207-215 -
Prolonged bihemispheric alterations in unfolded protein response related gene expression after experimental stroke
Rissanen A, Sivenius J, Jolkkonen J. 2006. Brain research. 1087: 60-66 -
Behavioral and histological effects of chronic antipsychotic and antidepressant drug treatment in aged rats with focal ischemic brain injury
Zhao C, Puurunen K, Schallert T, Sivenius J, Jolkkonen J. 2005. Behavioural brain research. 158: 211-220 -
Behavioral effects of photothrombotic ischemic cortical injury in aged rats treated with the sedative-hypnotic GABAergic drug zopiclone
Zhao C, Puurunen K, Schallert T, Sivenius J, Jolkkonen J. 2005. Behavioural brain research. 160: 260-266 -
Effect of cholinergic medication, before and after focal photothrombotic ischemic cortical injury, on histological and functional outcome in aged and young adult rats
Zhao C, Puurunen K, Schallert T, Sivenius J, Jolkkonen J. 2005. Behavioural brain research. 156: 85-94 -
Epileptogenesis after experimental focal cerebral ischemia
Karhunen H, Jolkkonen J, Sivenius J, Pitkänen A. 2005. Neurochemical research. 30: 1529-1542 -
Imaging D2-receptors in quinolinic acid lesioned rat striatum with high resolution pinhole SPECT
Sohlberg A, Jolkkonen J, Ruotsalainen U, Kuikka JT. 2005. Nuklearmedizin-nuclear medicine. 44: N43-N45 -
Psychotropic medication and stroke outcome
Zhao C, Puurunen K, Sivenius J, Jolkkonen J, Schallert T. 2005. American journal of psychiatry -
Transformation of diffuse beta-amyloid precursor protein and beta-amyloid deposits to plaques in the thalamus after transient occlusion of the middle cerebral artery in rats
van Groen T, Puurunen K, Mäki H-M, Sivenius J, Jolkkonen J. 2005. Stroke. 36: 1551-1556 -
Neuroprotection by the alfa2-adrenoceptor agonist, dexmedetomidine, in experimental stroke models
Puurunen K, Jolkkonen J, Sivenius J. 2004. VASCULAR DISEASE PREVENTION. 1: 117-122 -
Re: External carotid artery territory ischemia impairs outcome in the endovascular filament model of middle cerebral artery occlusion in rats
Virtanen T, Jolkkonen J, Sivenius J, Sivenius J. 2004. Stroke -
Uutta näyttöä aivohalvauskuntoutuksen vaikutuksista
Sivenius J, Jolkkonen J, Sivenius J. 2004. Duodecim -
Behavioral deficits and recovery following transient focal cerebral ischemia in rats: glutamatergic and GABAergic receptor densities
Jolkkonen J, Palamero Gallagher N, Zilles K, Sivenius J. 2003. Behavioural brain research. 138: 187-200 -
Dehydration and stress do not explain severe weight loss after experimental stroke in rats
Virtanen T, Sivenius J, Jolkkonen J. 2003. Journal of animal and veterinary advances. 2: 247-252 -
Forelimb use after focal cerebral ischemia in rats treated with an alpha2-adrenoceptor antagonist
Karhunen H, Virtanen T, Schallert T, Sivenius J, Jolkkonen J. 2003. Pharmacology biochemistry and behavior. 74: 663-669 -
Long-term functional consequences of transient occlusion of the middle cerebral artery in rats: a 1-year follow-up of the development of epileptogenesis and memory impairment in relation to sensorimotor deficits
Karhunen H, Pitkänen A, Virtanen T, Gureviciene I, Pussinen R, Ylinen A, Sivenius J, Nissinen J, Jolkkonen J. 2003. Epilepsy research. 54: 1-10 -
Aivohalvauspotilaiden kuntoutusmahdollisuudet tulevaisuudessa
Sivenius J, Puurunen K, Tarkka IM, Jolkkonen J. 2002. Duodecim. 118: 2569-2576 -
Diazepam does not reduce infarct size in rats subjected to transient occlusion of the middle cerebral artery when normothermia is maintained
Kuhmonen J, Lukkarinen J, Gröhn O, Jolkkonen J, Sivenius J. 2002. Journal of pharmacy and pharmacology. 54: 1565-1569 -
Differentially altered cerebral metabolism in ischemic rats by alfa2-adrenoceptor blockade and its relation to improved limb-placing reactions
Barbelivien A, Jolkkonen J, Rutkauskaite E, Sirviö J, Sivenius J. 2002. Neuropharmacology. 42: 117-126 -
11th Nordic Meeting on Cerebrovascular Diseases and 2nd Biennial Symposium on Ischaemic Stroke
Jolkkonen J, Kauppinen R, Koistinaho J. 2001. Kuopion yliopisto. Neurologian klinikan julkaisusarja, No. . - -
An alfa2-adrenergic antagonist, atipamezole, facilitates behavioral recovery after focal cerebral ischemia in rats
Puurunen K, Jolkkonen J, Sirviö J, Haapalinna A, Sivenius J. 2001. Neuropharmacology. 40: 597-606 -
Differential effect of the alfa2-adrenoceptor antagonist, atipamezole, in limb-placing task and skilled forepaw use following experimental stroke
Butovas S, Lukkarinen J, Virtanen T, Jolkkonen J, Sivenius J. 2001. Restorative neurology and neuroscience. 18: 143-151 -
Enriched-environment housing increases neuronal Fos-staining in the dentate gyrus after a water maze spatial learning task
Puurunen K, Koistinaho J, Sirviö J, Jolkkonen J, Sivenius J. 2001. Neuropharmacology. 40: 440-447 -
Selegiline combined with enriched-environment housing attenuates spatial learning deficits following focal cerebral ischemia in rats
Puurunen K, Jolkkonen J, Sirviö J, Haapalinna A, Sivenius J. 2001. Experimental neurology. 167: 348-355 -
Behavioral effects of the alpha2-adrenoceptor antagonist, atipamezole, after focal cerebral ischemia in rats
Jolkkonen J, Puurunen K, Rantakömi S, Härkönen A, Haapalinna A, Sivenius J. 2000. European journal of pharmacology. 400: 211-219 -
Effects of fluoxetine on sensorimotor and spatial learning deficits following focal cerebral ischemia in rats
Jolkkonen J, Puurunen K, Rantakömi S, Sirviö J, Haapalinna A, Sivenius J. 2000. Restorative neurology and neuroscience. 17: 211-216 -
MAO-B inhibition by a single dose of l-Deprenyl or Lazabemide does not prevent neuronal damage following focal cerebral ischaemia in rats
Jolkkonen J, Kauppinen R, Nyman L, Haapalinna A, Sivenius J. 2000. Basic and clinical pharmacology and toxicology. 87: 242-245 -
The neuroprotective effects of (-)deprenyl in the gerbil hippocampus following transient global ischemia
Kuhmonen J, Jolkkonen J, Haapalinna A, Sivenius J. 2000. Journal of neural transmission. 107: 779-786 -
Transgenic mice overexpressing truncated trkB neurotophin receptors in neurons show incresed susceptibility to cortical injury after focal cerebral inschemia
Saarelainen T, Lukkarinen JA, Koponen S, Gröhn OHJ, Jolkkonen J, Koponen E, Haapasalo A, Alhonen L, Wong G, Koistinaho J, Kauppinen RA, Castrén E. 2000. Molecular and cellular neuroscience. 16: 87-96 -
Do GABAergic circuitries play a critical role in the regulation of seizure-induced neuronal damage and synaptic reorganization in the rat hippocampus?
Pitkänen A, Jolkkonen J. 1999. ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY. SUPPLEMENT. : 443-449 -
Neuroprotection by the alpha2-adrenoceptor agonist, dexmedetomidine, in rat focal cerebral ischemia
Jolkkonen J, Puurunen K, Koistinaho J, Kauppinen R, Haapalinna A, Nieminen L, Sivenius J. 1999. European journal of pharmacology. 372: 31-36 -
Systemic administration of atipamezole, a selective antagonist of alpha-2 adrenoceptors, facilitates behavioural activity but does not influence short-term or long-term memory in trimethyltin-intoxicated and control rats
Niittykoski M, Lappalainen R, Jolkkonen J, Haapalinna A, Riekkinen P Sr, Sirviö J. 1998. Neuroscience and biobehavioral reviews. 22: 735-750 -
Cholinergic deafferentation exacerbates seizure-induced loss of somatostatin-immunoreactive neurons in the rat hippocampus
Jolkkonen J, Kähkönen K, Pitkänen A. 1997. Neuroscience. 80: 401-411 -
Neuroprotective effects of dexmedetomidine in the gebril hippocampus after transient global ischemia
Kuhmonen J, Pokornÿ J, Miettinen R, Haapalinna A, Jolkkonen J, Riekkinen P Sr, Sivenius J. 1997. Anesthesiology. 87: 371-377 -
Seizure-induced damage to somatostatin-immunoreactive neurons in the rat hippocampus is regulated by fimbria-fornix transection
Jolkkonen J, Jolkkonen E, Pitkänen A. 1997. Experimental neurology. 145: 141-153 -
Analysis of low-dose benzodiatzepines by HPLC with automated solid-phase extraction
Åkerman KK, Jolkkonen J, Parviainen M, Penttilä I. 1996. Clinical chemistry. 42: 1412-1416 -
Seizure-induced damage to the hippocampus is prevented by modulation of the GABAergic system
Jolkkonen J, Halonen T, Jolkkonen E, Nissinen J, Pitkänen A. 1996. Neuroreport. 7: 2031-2035 -
Vasopressin in the cerebrospinal fluid of febrile children with or without seizures
Kiviranta T, Tuomisto L, Jolkkonen J, Airaksinen EM. 1996. Brain and development. 18: 110-113 -
Cerebrospinal fluid gamma-aminobutyric acid in patients with panic disorder
Rimon R, Lepola U, Jolkkonen J, Halonen T, Riekkinen P. 1995. Biological psychiatry. 38: 737-741 -
L-DOPA reverses altered gene expression of substance P but not enkephalin in the caudate-putamen of common marmosets treated with MPTP
Jolkkonen J, Jenner P, Marsden CD. 1995. MOLECULAR BRAIN RESEARCH. 32: 297-307