Jukka Jolkkonen

Bakreen, Abdulhameed; Juntunen, Miia; Dunlop, Yannick; Ugidos, Irene F.; Malm, Tarja; Miettinen, Susanna; Jolkkonen, Jukka. 2021. Additive Behavioral Improvement after Combined Cell Therapy and Rehabilitation Despite Long-Term Microglia Presence in Stroke Rats International journal of molecular sciences 22 4: 1512. 2021

Boltze, Johannes; Aronowski, Jaroslaw A; Badaut, Jerome; Buckwalter, Marion S; Caleo, Mateo; Chopp, Michael; Dave, Kunjan R; Didwischus, Nadine; Dijkhuizen, Rick M; Doeppner, Thorsten R; Dreier, Jens P; Fouad, Karim; Gelderblom, Mathias; Gertz, Karen; Golubczyk, Dominika; Gregson, Barbara A; Hamel, Edith; Hanley, Daniel F; Haertig, Wolfgang; Hummel, Friedhelm C et al. (Incl. Jolkkonen, Jukka). 2021. New Mechanistic Insights, Novel Treatment Paradigms, and Clinical Progress in Cerebrovascular Diseases Frontiers in aging neuroscience 13: 623751. 2021

Bister, Nea; Pistono, Cristiana; Huremagic, Benjamin; Jolkkonen, Jukka; Giugno, Rosalba; Malm, Tarja. 2020. Hypoxia and extracellular vesicles: A review on methods, vesicular cargo and functions Journal of extracellular vesicles 10 1: e12002. 2020

Hu, Jingman; Jolkkonen, Jukka; Zhao, Chuansheng. 2020. Neurotropism of SARS-CoV-2 and its neuropathological alterations: Similarities with other coronaviruses Neuroscience and biobehavioral reviews 119: 184-193. 2020

Liu, Fangxi; Cheng, Xi; Zhong, Shanshan; Liu, Chang; Jolkkonen, Jukka; Zhang, Xiuchun; Liang, Yifan; Liu, Zhouyang; Zhao, Chuansheng. 2020. Communications Between Peripheral and the Brain-Resident Immune System in Neuronal Regeneration After Stroke Frontiers in immunology 11: 1-14. 2020

Neurorepair Strategies After Stroke. Zhao, Chuansheng; Jolkkonen, Jukka / Stroke Revisited: Pathophysiology of Stroke. From Bench to Bedside. 2020. 2020

Palà, Elena; Bustamante, Alejandro; Jolkkonen, Jukka; Hommel, Marc; Rosell, Anna; Montaner, Joan. 2020. Blood-based Biomarkers and Stem Cell Therapy in Human Stroke: A Systematic Review Molecular biology reports 47: 6247-6258. 2020

Boltze, Johannes; Didwischus, Nadine; Li, Shen; Jolkkonen, Jukka; Taguchi, Akihiko. 2020. Increased migratory and homing abilities of neural and mesenchymal stem cell populations by transient cell modifications: Preclinical progress and clinical relevance EBioMedicine 60: 103022. 2020

8th Kuopio Stroke Symposium: A Global Action Against Stroke: Kuopio, Finland, June 5-7, 2019: Program and Abstracts. Jolkkonen, Jukka. 2019 2019

Boltze, J; Modo, MM; Mays, RW; Taguchi, A; Jolkkonen, J; Savitz, SI. 2019. Stem Cells as an Emerging Paradigm in Stroke 4: Advancing and Accelerating Preclinical Research Stroke 50 11: 3299-3306. 2019

Boltze, Johannes; Jolkkonen, Jukka. 2019. Safety evaluation of intra-arterial cell delivery in stroke patients'a framework for future trials Annals of translational medicine 7 Supplement 8: S271. 2019

Cui, LL; Golubczyk, D; Tolppanen, AM; Boltze, J; Jolkkonen, J. 2019. Cell therapy for ischemic stroke: are differences in preclinical and clinical study design responsible for the translational loss of efficacy? Annals of neurology 86 1: 5-16. 2019

Diekhorst, L; Gómez-de Frutos, MC; Laso-García, F; Otero-Ortega, L; Fuentes, B; Jolkkonen, J; Detante, O; Moisan, A; Leyva, L; Martínez-Arroyo, A; Díez-Tejedor, E; Gutiérrez-Fernández, M; on behalf of RESSTORE Consortium. 2019. Mesenchymal Stem Cells From Adipose Tissue Do not Improve Functional Recovery After Ischemic Stroke in Hypertensive Rats Stroke 2020; 51 1: 342-346. 2019

Dong, BC; Li, MX; Wang, XY; Cheng, X; Wang, Y; Xiao, T; Jolkkonen, J; Zhao, CS; Zhao, SS. 2019. Effects of CXCR7-neutralizing antibody on neurogenesis in the hippocampal dentate gyrus and cognitive function in the chronic phase of cerebral ischemia Neural regeneration research 2020; 15 6: 1079-1085. 2019

Gómez-de Frutos, MC; Laso-García, F; Diekhorst, L; Otero-Ortega, L; Fuentes, B; Jolkkonen, J; Detante, O; Moisan, A; Martínez-Arroyo, A; Díez-Tejedor, E; Gutiérrez-Fernández, M. 2019. Intravenous delivery of adipose tissue-derived mesenchymal stem cells improves brain repair in hyperglycemic stroke rats Stem cell research & therapy 10: 212. 2019

Mu, Jingwei; Bakreen, Abdulhameed; Juntunen, Miia; Korhonen, Paula; Oinonen, Ella; Cui, Lili; Myllyniemi, Mikko; Zhao, Shanshan; Miettinen, Susanna; Jolkkonen, Jukka. 2019. Combined Adipose Tissue-Derived Mesenchymal Stem Cell Therapy and Rehabilitation in Experimental Stroke Frontiers in neurology 10: 235. 2019

Zhao, Chuansheng; Könönen, Mervi; Vanninen, Ritva; Pitkänen, Kauko; Hiekkala, Sinikka; Jolkkonen, Jukka. 2018. Translating experimental evidence to finding novel ways to promote motor recovery in stroke patients - a review RESTORATIVE NEUROLOGY AND NEUROSCIENCE 36 4: 519-533. 2018

Balkaya, Mustafa G; Trueman, Rebecca C; Boltze, Johannes; Corbett, Dale; Jolkkonen, Jukka. 2018. Behavioral outcome measures to improve experimental stroke research BEHAVIOURAL BRAIN RESEARCH 352: 161-171. 2018

Modo, MM; Jolkkonen, J; Zille, M; Boltze, J. 2018. Future of Animal Modeling for Poststroke Tissue Repair Stroke 49 5: 1099-1106. 2018

Cui, Lili; Moisan, Anaick; Jolkkonen, Jukka. 2018. Intravascular cell therapy in stroke: predicting the future trends Regenerative Medicine 2019; 14 1: 63-68. 2018

Boltze J, Nitzsche F, Jolkkonen J, Weise G, Posel C, Nitzsche B, Wagner DC. 2017. Concise Review: Increasing the Validity of Cerebrovascular Disease Models and Experimental Methods for Translational Stem Cell Research. STEM CELLS 35 3: 1141-1153. 2017

Corbett Dale, Carmichael S Thomas, Murphy Timothy H, Jones Theresa A, Schwab Martin E, Jolkkonen Jukka, Clarkson Andrew N, Dancause Numa, Weiloch Tadeusz, Johansen-Berg Heidi, Nilsson Michael, McCullough Louise D, Joy Mary T. 2017. Enhancing the alignment of the preclinical and clinical stroke recovery research pipeline: Consensus-based core recommendations from the Stroke Recovery and Rehabilitation Roundtable translational working group International journal of stroke 12 5: 462-471. 2017

Corbett Dale, Carmichael S Thomas, Murphy Timothy H, Jones Theresa A, Schwab Martin E, Jolkkonen Jukka, Clarkson Andrew N, Dancause Numa, Weiloch Tadeusz, Johansen-Berg Heidi, Nilsson Michael, McCullough Louise D, Joy Mary T. 2017. Enhancing the Alignment of the Preclinical and Clinical Stroke Recovery Research Pipeline: Consensus-Based Core Recommendations From the Stroke Recovery and Rehabilitation Roundtable Translational Working Group. NEUROREHABILITATION AND NEURAL REPAIR 31 8: 699-707. 2017

Cui LL, Golubczyk D, Jolkkonen J. 2017. Top 3 Behavioral Tests in Cell Therapy Studies After Stroke: Difficult to Stop a Moving Train. STROKE 48 11: 3165-3167. 2017

Cui LL, Nitzsche F, Pryazhnikov E, Tibeykina M, Tolppanen L, Rytkönen J, Huhtala T, Mu JW, Khiroug L, Boltze J, Jolkkonen J. 2017. Integrin [alpha]4 Overexpression on Rat Mesenchymal Stem Cells Enhances Transmigration and Reduces Cerebral Embolism After Intracarotid Injection. STROKE 48 10: 2895-2900. 2017

Detante Olivier, Muir Keith, Jolkkonen Jukka. 2017. Cell Therapy in Stroke - Cautious Steps Towards a Clinical Treatment. Translational stroke research [Epub 2017 Nov 17]: 1-12. 2017

Mu XP, Wang HB, Cheng X, Yang L, Sun XY, Qu HL, Zhao SS, Zhou ZK, Liu TT, Xiao T, Song B, Jolkkonen J, Zhao CS. 2017. Inhibition of Nkcc1 Promotes Axonal Growth and Motor Recovery in Ischemic Rats. NEUROSCIENCE 365: 83-93. 2017

Nitzsche F, Muller C, Lukomska B, Jolkkonen J, Deten A, Boltze J. 2017. Concise Review: MSC Adhesion Cascade-Insights into Homing and Transendothelial Migration. STEM CELLS 35 6: 1446-1460. 2017

Nowakowski A, Andrzejewska A, Boltze J, Nitzsche F, Cui LL, Jolkkonen J, Walczak P, Lukomska B, Janowski M. 2017. Translation, but not transfection limits clinically relevant, exogenous mRNA based induction of alpha-4 integrin expression on human mesenchymal stem cells. Scientific Reports 7: 1103. 2017

Pitkänen Kauko, Jäkälä Pekka, Jolkkonen Jukka. 2017. Aivoverenkiertohäiriöt ja diabetes - mitä uutta? BestPractice: Diabetes ja sydänsairaudet 5 Nro 17. Maaliskuu 2017: 8-10. 2017

Zhang Xiao Qian, Mu Jing Wei, Wang Hui Bin, Jolkkonen Jukka, Liu Ting Ting, Xiao Ting, Zhao Mei, Zhang Chao Dong, Zhao Chuan Sheng. 2016. Increased protein expression levels of pCREB, BDNF and SDF-1/CXCR4 in the hippocampus may be associated with enhanced neurogenesis induced by environmental enrichment. Molecular Medicine Reports 14 3: 2231-2237. 2016

Xu W, Mu X, Wang H, Song C, Ma W, Jolkkonen J, Zhao C. 2016. Chloride Co-transporter NKCC1 Inhibitor Bumetanide Enhances Neurogenesis and Behavioral Recovery in Rats After Experimental Stroke. MOLECULAR NEUROBIOLOGY 54 4: 2406-2414. 2016

Jolkkonen J, Mendez-Otero R, de Freitas GR, Boltze J, Rosado-de-Castro PH. 2016. The Current State of Cell Therapies for Cerebrovascular Diseases. Stem Cells International 2016: -. 2016

7th Kuopio Stroke Symposium : From bench to bedside and back : Kuopio, Finland, June 8-10, 2016 : program and abstracts. Jolkkonen Jukka. 2016 2016

Jolkkonen Jukka, Kwakkel Gert. 2016. Translational Hurdles in Stroke Recovery Studies. Translational stroke research 7 4: 331-342. 2016

Cui Li-li, Kinnunen Tuure, Boltze Johannes, Nystedt Johanna, Jolkkonen Jukka. 2016. Clumping and Viability of Bone Marrow Derived. Stem Cells International 2016: 8 pages. 2016

Borlongan Cesar V, Jolkkonen Jukka, Detante Olivier. 2015. The future of stem cell therapy for stroke rehabilitation. FUTURE NEUROLOGY 10 4: 313-319. 2015

Cui Li-Li, Kerkelä Erja, Bakreen Abdulhameed, Nitzsche Franziska, Andrzejewska Anna, Nowakowski Adam, Janowski Miroslaw, Walczak Piotr, Boltze Johannes, Lukomska Barbara, Jolkkonen Jukka. 2015. The cerebral embolism evoked by intra-arterial delivery of allogeneic bone marrow mesenchymal stem cells in rats is related to cell dose and infusion velocity. Stem Cell Research & Therapy 6 1: 9 pages. 2015

Kuptsova Kristina, Kvist Elisabet, Nitzsche Franziska, Jolkkonen Jukka. 2015. Combined enriched environment/atipamezole treatment transiently improves sensory functions in stroke rats independent from neurogenesis and angiogenesis. Romanian Journal of Morphology & Embryology 56 1: 41-47. 2015

Li Shen, Sun Xin, Bai Yu-meng, Qin Hua-min, Wu Xiao-mei, Zhang Xiao, Jolkkonen Jukka, Boltze Johannes, Wang Su-ping. 2015. Infarction of the Corpus Callosum : A Retrospective Clinical Investigation. PLOS ONE [ONLINE] 10 3: e0120409. 2015

Mering Satu, Jolkkonen Jukka. 2015. Proper housing conditions in experimental stroke studies - special emphasis on environmental enrichment. Frontiers in Neuroscience 9 106: 8 pages. 2015

Mitkari Bhimashankar, Kerkelä Erja, Nystedt Johanna, Korhonen Matti, Jolkkonen Jukka. 2015. Unexpected complication in a rat stroke model: exacerbation of secondary pathology in the thalamus by subacute intraarterial administration of human bone marrow-derived mesenchymal stem cells. Journal of Cerebral Blood Flow & Metabolism 35 3: 363-366. 2015

Sun X, Sun X, Liu T, Zhao M, Zhao S, Xiao T, Jolkkonen J, Zhao C. 2015. Fluoxetine enhanced neurogenesis is not translated to functional outcome in stroke rats. NEUROSCIENCE LETTERS 603: 31-36. 2015

Sun X, Zhou Z, Liu T, Zhao M, Zhao S, Xiao T, Jolkkonen J, Zhao C. 2015. Fluoxetine Enhances Neurogenesis in Aged Rats with Cortical Infarcts, but This is not Reflected in a Behavioral Recovery. JOURNAL OF MOLECULAR NEUROSCIENCE 2016; 58 2: 233-242. 2015

Zhao S, Qu H, Zhao Y, Xiao T, Zhao M, Li Y, Jolkkonen J, Cao Y, Zhao C. 2015. CXCR4 antagonist AMD3100 reverses the neurogenesis and behavioral recovery promoted by forced limb-use in stroke rats. RESTORATIVE NEUROLOGY AND NEUROSCIENCE 33 6: 809-821. 2015

Boltze Johannes, Arnold Antje, Walczak Piotr, Jolkkonen Jukka, Cui Lili, Wagner Daniel-Christoph. 2015. The dark side of the force - constraints and complications of cell therapies for stroke. Frontiers in Neurology 6 -: 155. 2015

Qu HL, Zhao M, Zhao SS, Xiao T, Song CG, Cao YP, Jolkkonen J, Zhao CS. 2014. Forced limb-use enhanced neurogenesis and behavioral recovery after stroke in the aged rats. NEUROSCIENCE 2014 Available online 26 November 2014: 1-8. 2014

Qu H, Zhao M, Zhao S, Xiao T, Tang X, Zhao D, Jolkkonen J, Zhao C. 2014. Forced limb-use enhances brain plasticity through the cAMP/PKA/CREB signal transduction pathway after stroke in adult rats. RESTORATIVE NEUROLOGY AND NEUROSCIENCE 32 5: 597-609. 2014

Lipsanen Anu, Parkkinen Saara, Khabbal Joonas, Mäkinen Petra, Peräniemi Sirpa, Hiltunen Mikko, Jolkkonen Jukka. 2014. KB-R7943, an inhibitor of the reverse Na(+)/Ca(2+) exchanger, does not modify secondary pathology in the thalamus following focal cerebral stroke in rats. NEUROSCIENCE LETTERS 580: 173-177. 2014

Khabbal J, Kerkelä E, Mitkari B, Raki M, Nystedt J, Mikkonen V, Bergström K, Laitinen S, Korhonen M, Jolkkonen J. 2014. Differential Clearance of Rat and Human Bone Marrow-Derived Mesenchymal Stem Cells from the Brain After Intra-arterial Infusion in Rats. Cell Transplantation 2014: -. 2014

Boltze Johannes, Lukomska Barbara, Jolkkonen Jukka, MEMS-IRBI consortium, Collaborators:, Andrzejewska A, Cui L, Deten A, Nitzsche F, Nowakowski A, Wagner DC, Walczak P. 2014. Mesenchymal stromal cells in stroke: improvement of motor recovery or functional compensation?. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 34 8: 1420-1421. 2014

Mitkari B, Nitzsche F, Kerkelä E, Kuptsova K, Huttunen J, Nystedt J, Korhonen M, Jolkkonen J. 2013. Human bone marrow mesenchymal stem/stromal cells produce efficient localization in the brain and enhanced angiogenesis after intra-arterial delivery in rats with cerebral ischemia, but this is not translated to behavioral recovery. BEHAVIOURAL BRAIN RESEARCH -: -. 2013

Zhao S-S, Zhao Y, Xiao Y, Xiao T, Zhao M, Jolkkonen J, Zhan C-S. 2013. Increased neurogenesis contributes to the promoted behavioral recovery by constraint-induced movement therapy after stroke in adult rats. CNS Neuroscience & Therapeutics 19: 194-196. 2013

Zhao S, Zhao M, Xiao T, Jolkkonen J, Zhao C. 2013. Constraint-induced movement therapy overcomes the intrinsic axonal growth-inhibitory signals in stroke rats. STROKE 44: 1698-1705. 2013

Parkkinen S, Ortega FJ, Kuptsova K, Huttunen J, Tarkka I, Jolkkonen J. 2013. Gait impairment in a rat model of focal cerebral ischemia. Stroke Research and Treatment - Article ID 410972: 12 pages. 2013

Ortega FJ, Jolkkonen J. 2013. Restorative therapies to enhance sensorimotor recovery following cerebral ischemia. ACTA NEUROBIOLOGIAE EXPERIMENTALIS 73: 66-78. 2013

Ortega FJ, Jolkkonen J, Rodriguez. 2013. Microglia is an active player in how glibenclamide improves stroke outcome. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 33: 1138-1139. 2013

Lipsanen A, Kalesnykas G, Pro-Sistiaga P, Hiltunen M, Vanninen R, Bernaudin M, Touzani O, Jolkkonen J. 2013. Lack of secondary pathology in the thalamus after focal cerebral ischemia in nonhuman primates. EXPERIMENTAL NEUROLOGY 248: 224-227. 2013

Mitkari B, Kerkelä E, Nystedt J, Korhonen M, Mikkonen V, Huhtala T, Jolkkonen J. 2013. Intra-arterial infusion of human bone marrow-derived mesenchymal stem cells results in transient localization in the brain after cerebral ischemia in rats. EXPERIMENTAL NEUROLOGY 239: 158-162. 2013

Lipsanen A, Flunkert S, Kuptsova K, Hiltunen M, Windisch M, Hutter-Paier B, Jolkkonen J. 2013. Non-selective calcium channel blocker bepridil decreases secondary pathology in mice after photothrombotic cortical lesion. PLOS ONE [ONLINE] 8 3: e60235. 2013

Korhonen M, Jolkkonen J. 2013. Intravascular cell therapy in stroke patients: where the cells go and what they do. Regenerative Medicine 8 2: 93-95. 2013

Jolkkonen J, Ortega FJ, Jäkälä P. 2013. Kuntoutumisen tehostamista lääkehoidolla. Suomen aivotutkimus- ja kuntoutuskeskus Neuronin asiakaslehti -: 8-10. 2013

Cui L, Huiling Q, Xiao T, Zhao M, Jolkkonen J, Zhao C. 2013. Stromal cell-derived factor-1 and its receptor CXCR4 in adult neurogenesis after cerebral ischemia. RESTORATIVE NEUROLOGY AND NEUROSCIENCE 31 3: 239-251. 2013

Cell-Based Therapies in Stroke. Jolkkonen J, Walczak P. 2013 2013

Baki M, Bergström K, Jolkkonen J. 2013. In Vivo Biodistribution Studies and Cell Tracking in Stroke Using SPECT Imaging: Jolkkonen J, Walczak P, Cell-Based Therapies in Stroke. 137-149. 2013

Mitkari B, Kerkelä E, Nystedt J, Korhonen M, Huhtala T, Jolkkonen J. 2012. Toward a more effective intravascular cell therapy in stroke: Balestrino M, Advances in the Treatment of Ischemic Stroke. 141-160. 2012

Sarajärvi Timo, Lipsanen Anu, Mäkinen Petra, Peräniemi Sirpa, Soininen Hilkka, Haapasalo Annakaisa, Jolkkonen Jukka, Hiltunen Mikko. 2012. Bepridil decreases Aβ and calcium levels in the thalamus after middle cerebral artery occlusion in rats. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 16 11: 2754-2767. 2012

Ortega FJ, Jolkkonen J, Mahy N, Rodriquez MJ. 2012. Glibenclamide enhances neurogenesis and improves long-term functional recovery after transient focal cerebral ischemia. Journal of Cerebral Blood Flow & Metabolism online: 1-9. 2012

Jäkälä P, Jolkkonen J. 2012. Time for a neurorestorative therapy in stroke EXPERT OPINION ON BIOLOGICAL THERAPY 12 3: 267-270. 2012

Hiltunen Mikko, Jolkkonen Jukka. 2012. Letter by Hiltunen and Jolkkonen Regarding Article, "Secondary Neurodegeneration in Remote Regions After Focal Cerebral Infarction: A New Target for Stroke Management?". STROKE 43: e97. 2012

Hiltunen M, Jolkkonen J. 2012. Secondary neurodegeneration in remote regions after focal cerebral infarction: A new target for Stroke Management STROKE 43: e96. 2012

Hayward Nick MEA, Yanev Pavel, Haapasalo Annakaisa, Miettinen Riitta, Hiltunen Mikko, Gröhn Olli, Jolkkonen Jukka. 2011. Chronic hyperperfusion and angiogenesis follow subacute hypoperfusion in the thalamus of rats with focal cerebral ischemia. Journal of Cerebral Blood Flow & Metabolism 31: 1119-1132. 2011

Hiltunen M, Jolkkonen J. 2011. Complex pathology in the thalamus following cerebral ischemia: Song JL, Thalamus: Anatomy, Functions and Disorders. 83-98. 2011

Lipsanen Anu ja Jolkkonen Jukka. 2011. Experimental approaches to study functional recovery following cerebral ischemia CELLULAR AND MOLECULAR LIFE SCIENCES: CMLS 68 18: 3007-3017. 2011

Lipsanen Anu, Hiltunen Mikko, Jolkkonen Jukka. 2011. Chronic ibuprofen treatment does not affect the secondary pathology in the thalamus or improve behavioral outcome in middle cerebral artery occlusion rats. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 99: 468-474. 2011

Pluta R, Jolkkonen J, Cuzzocrea S, Pedata F, Cechetto D, Popa-Wagner A. 2011. Cognitive impairment with vascular impairment and degeneration Current Neurovascular Research 8: 342-350. 2011

Yanev P, Jolkkonen J, Airenne KJ, Ylä-Herttuala S & Wirth T. 2010. Enhanced angiogenesis and reduced infarct size by vascular endothelial growth factor D is not translated to behavioral outcome in a rat model of ischemic stroke. JOURNAL OF EXPERIMENTAL STROKE & TRANSLATIONAL MEDICINE 3: 1-12. 2010

Hicks A, Jolkkonen J. 2009. Challenges and possibilities of intravascular cell therapy in stroke. ACTA NEUROBIOLOGIAE EXPERIMENTALIS 69: 1-10. 2009

Hicks A, Schallert T, Jolkkonen J. 2009. Cell-based therapies and functional outcome in experimental stroke. CELL STEM CELL 5 2: 139-140. 2009

Hicks AU, Lappalainen RS, Narkilahti S, Suuronen R, Corbett D, Sivenius J, Hovatta O, Jolkkonen J, Sivenius J. 2009. Transplantation of human embryonic stem cell-derived neural precursor cells and enriched environment after cortical stroke in rats: cell survival and functional recovery. EUROPEAN JOURNAL OF NEUROSCIENCE (OXFORD) 29: 562-574. 2009

Hiltunen M, Mäkinen P, Peräniemi S, Sivenius J, van Groen T, Soininen H, Jolkkonen J, Hiltunen M, Sivenius J, Soininen H. 2009. Focal cerebral ischemia in rats alters APP processing and expression of Abeta peptide degrading enzymes in the thalamus. NEUROBIOLOGY OF DISEASE (SAN DIEGO CA) 35: 103-113. 2009

Hiltunen M, van Groen T, Jolkkonen J. 2009. Functional roles of amyloid-beta protein precursor and amyloid-beta peptides: Evidence from experimental studies. Journal of Alzheimer's Disease 18: 401-412. 2009

Zhao CS, Hartikainen S, Schallert T, Sivenius J, Jolkkonen J, Sivenius J. 2008. CNS-active drugs in aging population at high risk of cerebrovascular events: Evidence from preclinical and clinical studies. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS 32: 56-71. 2008

Mäkinen S, van Groen T, Clarke J, Thornell A, Corbett D, Hiltunen M, Soininen H, Jolkkonen J, Hiltunen M, Soininen H. 2008. Coaccumulation of calcium and b-amyloid in the thalamus after transient middle cerebral artery occlusion in rats JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 28: 263-268. 2008

Lappalainen RS, Narkilahti S, Huhtala T, Liimatainen T, Suuronen T, Närvänen A, Suuronen R, Hovatta O, Jolkkonen J. 2008. The SPECT imaging shows the accumulation of neural progenitor cells into internal organs after systemic administration in middle cerebral artery occlusion rats. NEUROSCIENCE LETTERS 440: 246-250. 2008

Hätinen S, Sairanen M, Sirviö J, Jolkkonen J. 2008. Improved sensorimotor function by rolipram following focal cerebral ischemia in rats RESTORATIVE NEUROLOGY AND NEUROSCIENCE 26: 493-499. 2008

Kalesnykas G, Tuulos T, Uusitalo H, Jolkkonen J. 2008. Neurodegeneration and cellular stress in the retina and optic nerve in rat cerebral ischemia and hypoperfusion models. NEUROSCIENCE 155: 937-947. 2008

Karhunen H, Bezvenyuk Z, Nissinen J, Sivenius J, Jolkkonen J, Pitkänen A, Sivenius J. 2007. Epileptogenesis after cortical photothrombotic brain lesion in rats. NEUROSCIENCE 148 1: 314-324. 2007

Parkkinen J, Ojala P, Niiranen J, Jolkkonen J. 2007. Molecular mechanisms underlying neuroprotective effects of albumin after ischemic stroke. STROKE 38: 255. 2007

van Groen T, Kadish I, Jolkkonen J. 2007. Transient occlusion of the middle cerebral artery in rats leads to permanent amyloid deposits in the thalamus: Pluta R, Ischemia-Reperfusion Pathways in Alzheimer's Disease.Nova Science. 85-98. 2007

Jolkkonen J, van Groen T. 2007. Thalamic calcification and amyloid deposition following focal cerebral ischemia in rats. Teoksessa: Pluta R (toim.), Ischemia-Reperfusion Pathways in Alzheimer's Disease.Nova Science. ss. 99-111. 2007

Jolkkonen J, Jokivarsi K, Laitinen T, Gröhn O. 2007. Subacute hemorrhage and resolution of edema in Rose Bengal stroke model in rats coincides with improved sensorimotor functions. NEUROSCIENCE LETTERS 428 2-3: 99-102. 2007

Hicks AU, Hewlett K, Windle V, Chernenko G, Ploughman M, Jolkkonen J, Weiss S, Corbett D. 2007. Enriched environment enhances transplanted subventricular zone stem cell migration and functional recovery after stroke. NEUROSCIENCE 146: 31-40. 2007

Clarke J, Thornell A, Corbett D, Soininen H, Hiltunen M, Jolkkonen J, Soininen H. 2007. Overexpression of APP provides neuroprotection in the absence of functional benefit following middle cerebral artery occlusion in rats EUROPEAN JOURNAL OF NEUROSCIENCE (OXFORD) 26: 1845-1852. 2007

Aho L, Jolkkonen J, Alafuzoff I. 2006. Beta-amyloid aggregation in human brains with cerebrovascular lesions STROKE 37: 2940-2945. 2006

Karhunen H, Nissinen J, Sivenius J, Jolkkonen J, Pitkänen A. 2006. A long-term video-EEG and behavioral follow-up after endothelin-1 induced middle cerebral artery occlusion in rats. EPILEPSY RESEARCH 72: 25-38. 2006

Mäkinen S, Kekarainen T, Nystedt J, Liimatainen T, Huhtala T, Närvänen A, Laine J, Jolkkonen J. 2006. Human umbilical cord blood cells do not improve sensorimotor of cognitive outcome following transient middle cerebral artery occlusion in rats. BRAIN RESEARCH 1123: 207-215. 2006

Nystedt J, Mäkinen S, Laine J, Jolkkonen J. 2006. Human cord blood CD34+ cells and behavioral recovery following focal cerebral ischemia in rats. ACTA NEUROBIOLOGIAE EXPERIMENTALIS 66: 293-300. 2006

Rissanen A, Sivenius J, Jolkkonen J. 2006. Prolonged bihemispheric alterations in unfolded protein response related gene expression after experimental stroke. BRAIN RESEARCH 1087: 60-66. 2006

Sonninen R, Virtanen T, Sivenius J, Jolkkonen J. 2006. Gene expression profiling in the hippocampus of rats subjected to focal cerebral ischemia and enriched environment housing. RESTORATIVE NEUROLOGY AND NEUROSCIENCE 24: 17-23. 2006

Zhao C, Puurunen K, Sivenius J, Jolkkonen J, Schallert T. 2005. Psychotropic medication and stroke outcome. AMERICAN JOURNAL OF PSYCHIATRY 162 5: 1026-1027. 2005

Zhao C, Puurunen K, Schallert T, Sivenius J, Jolkkonen J. 2005. Effect of cholinergic medication, before and after focal photothrombotic ischemic cortical injury, on histological and functional outcome in aged and young adult rats. BEHAVIOURAL BRAIN RESEARCH 156: 85-94. 2005

Zhao C, Puurunen K, Schallert T, Sivenius J, Jolkkonen J. 2005. Behavioral effects of photothrombotic ischemic cortical injury in aged rats treated with the sedative-hypnotic GABAergic drug zopiclone. BEHAVIOURAL BRAIN RESEARCH 160: 260-266. 2005

Zhao C, Puurunen K, Schallert T, Sivenius J, Jolkkonen J. 2005. Behavioral and histological effects of chronic antipsychotic and antidepressant drug treatment in aged rats with focal ischemic brain injury BEHAVIOURAL BRAIN RESEARCH 158: 211-220. 2005

van Groen T, Puurunen K, Mäki H-M, Sivenius J, Jolkkonen J. 2005. Transformation of diffuse beta-amyloid precursor protein and beta-amyloid deposits to plaques in the thalamus after transient occlusion of the middle cerebral artery in rats. STROKE 36: 1551-1556. 2005

Karhunen H, Jolkkonen J, Sivenius J, Pitkänen A. 2005. Epileptogenesis after experimental focal cerebral ischemia. NEUROCHEMICAL RESEARCH 30 12: 1529-1542. 2005

Sohlberg A, Jolkkonen J, Ruotsalainen U, Kuikka JT. 2005. Imaging D2-receptors in quinolinic acid lesioned rat striatum with high resolution pinhole SPECT. NUKLEARMEDIZIN 44 5: N43-N45. 2005

Puurunen K, Jolkkonen J, Sivenius J. 2004. Neuroprotection by the alfa2-adrenoceptor agonist, dexmedetomidine, in experimental stroke models. VASCULAR DISEASE PREVENTION 1: 117-122. 2004

Sivenius J, Jolkkonen J, Sivenius J. 2004. Uutta näyttöä aivohalvauskuntoutuksen vaikutuksista. DUODECIM 120: 2369-2371. 2004

Virtanen T, Jolkkonen J, Sivenius J, Sivenius J. 2004. Re: External carotid artery territory ischemia impairs outcome in the endovascular filament model of middle cerebral artery occlusion in rats. STROKE 35 1: e9-e10. 2004

Jolkkonen J, Palamero Gallagher N, Zilles K, Sivenius J. 2003. Behavioral deficits and recovery following transient focal cerebral ischemia in rats: glutamatergic and GABAergic receptor densities. BEHAVIOURAL BRAIN RESEARCH 138: 187-200. 2003

Karhunen H, Pitkänen A, Virtanen T, Gureviciene I, Pussinen R, Ylinen A, Sivenius J, Nissinen J, Jolkkonen J. 2003. Long-term functional consequences of transient occlusion of the middle cerebral artery in rats: a 1-year follow-up of the development of epileptogenesis and memory impairment in relation to sensorimotor deficits. EPILEPSY RESEARCH 54 1: 1-10. 2003

Karhunen H, Virtanen T, Schallert T, Sivenius J, Jolkkonen J. 2003. Forelimb use after focal cerebral ischemia in rats treated with an alpha2-adrenoceptor antagonist. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 74: 663-669. 2003

Virtanen T, Sivenius J, Jolkkonen J. 2003. Dehydration and stress do not explain severe weight loss after experimental stroke in rats. JOURNAL OF ANIMAL AND VETERINARY ADVANCES 2 4: 247-252. 2003

Barbelivien A, Jolkkonen J, Rutkauskaite E, Sirviö J, Sivenius J. 2002. Differentially altered cerebral metabolism in ischemic rats by alfa2-adrenoceptor blockade and its relation to improved limb-placing reactions. NEUROPHARMACOLOGY 42 1: 117-126. 2002

Kuhmonen J, Lukkarinen J, Gröhn O, Jolkkonen J, Sivenius J. 2002. Diazepam does not reduce infarct size in rats subjected to transient occlusion of the middle cerebral artery when normothermia is maintained JOURNAL OF PHARMACY AND PHARMACOLOGY 54: 1565-1569. 2002

Sivenius J, Puurunen K, Tarkka IM, Jolkkonen J. 2002. Aivohalvauspotilaiden kuntoutusmahdollisuudet tulevaisuudessa. DUODECIM 118: 2569-2576. 2002

Puurunen K, Jolkkonen J, Sirviö J, Haapalinna A, Sivenius J. 2001. Selegiline combined with enriched-environment housing attenuates spatial learning deficits following focal cerebral ischemia in rats EXPERIMENTAL NEUROLOGY 167: 348-355. 2001

Puurunen K, Koistinaho J, Sirviö J, Jolkkonen J, Sivenius J. 2001. Enriched-environment housing increases neuronal Fos-staining in the dentate gyrus after a water maze spatial learning task. NEUROPHARMACOLOGY 40 3: 440-447. 2001

Puurunen K, Jolkkonen J, Sirviö J, Haapalinna A, Sivenius J. 2001. An alfa2-adrenergic antagonist, atipamezole, facilitates behavioral recovery after focal cerebral ischemia in rats. NEUROPHARMACOLOGY 40: 597-606. 2001

Butovas S, Lukkarinen J, Virtanen T, Jolkkonen J, Sivenius J. 2001. Differential effect of the alfa2-adrenoceptor antagonist, atipamezole, in limb-placing task and skilled forepaw use following experimental stroke. RESTORATIVE NEUROLOGY AND NEUROSCIENCE 18: 143-151. 2001

11th Nordic Meeting on Cerebrovascular Diseases and 2nd Biennial Symposium on Ischaemic Stroke. Jolkkonen J, Kauppinen R, Koistinaho J. 2001 2001

Jolkkonen J, Kauppinen R, Nyman L, Haapalinna A, Sivenius J. 2000. MAO-B inhibition by a single dose of l-Deprenyl or Lazabemide does not prevent neuronal damage following focal cerebral ischaemia in rats. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY 87: 242-245. 2000

Jolkkonen J, Puurunen K, Rantakömi S, Härkönen A, Haapalinna A, Sivenius J. 2000. Behavioral effects of the alpha2-adrenoceptor antagonist, atipamezole, after focal cerebral ischemia in rats EUROPEAN JOURNAL OF PHARMACOLOGY 400: 211-219. 2000

Jolkkonen J, Puurunen K, Rantakömi S, Sirviö J, Haapalinna A, Sivenius J. 2000. Effects of fluoxetine on sensorimotor and spatial learning deficits following focal cerebral ischemia in rats. RESTORATIVE NEUROLOGY AND NEUROSCIENCE 17: 211-216. 2000

Kuhmonen J, Jolkkonen J, Haapalinna A, Sivenius J. 2000. The neuroprotective effects of (-)deprenyl in the gerbil hippocampus following transient global ischemia. JOURNAL OF NEURAL TRANSMISSION 107: 779-786. 2000

Saarelainen T, Lukkarinen JA, Koponen S, Gröhn OHJ, Jolkkonen J, Koponen E, Haapasalo A, Alhonen L, Wong G, Koistinaho J, Kauppinen RA, Castrén E. 2000. Transgenic mice overexpressing truncated trkB neurotophin receptors in neurons show incresed susceptibility to cortical injury after focal cerebral inschemia MOLECULAR AND CELLULAR NEUROSCIENCE (SAN DIEGO CA) 16: 87-96. 2000

Pitkänen A, Jolkkonen J. 1999. Do GABAergic circuitries play a critical role in the regulation of seizure-induced neuronal damage and synaptic reorganization in the rat hippocampus?. ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY. SUPPLEMENT 50: 443-449. 1999

Jolkkonen J, Puurunen K, Koistinaho J, Kauppinen R, Haapalinna A, Nieminen L, Sivenius J. 1999. Neuroprotection by the alpha2-adrenoceptor agonist, dexmedetomidine, in rat focal cerebral ischemia. EUROPEAN JOURNAL OF PHARMACOLOGY 372: 31-36. 1999

Niittykoski M, Lappalainen R, Jolkkonen J, Haapalinna A, Riekkinen P Sr, Sirviö J. 1998. Systemic administration of atipamezole, a selective antagonist of alpha-2 adrenoceptors, facilitates behavioural activity but does not influence short-term or long-term memory in trimethyltin-intoxicated and control rats. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS 22 6: 735-750. 1998

Jolkkonen J, Jolkkonen E, Pitkänen A. 1997. Seizure-induced damage to somatostatin-immunoreactive neurons in the rat hippocampus is regulated by fimbria-fornix transection. EXPERIMENTAL NEUROLOGY 145: 141-153. 1997

Jolkkonen J, Kähkönen K, Pitkänen A. 1997. Cholinergic deafferentation exacerbates seizure-induced loss of somatostatin-immunoreactive neurons in the rat hippocampus. NEUROSCIENCE 80 2: 401-411. 1997

Kuhmonen J, Pokornÿ J, Miettinen R, Haapalinna A, Jolkkonen J, Riekkinen P Sr, Sivenius J. 1997. Neuroprotective effects of dexmedetomidine in the gebril hippocampus after transient global ischemia. ANESTHESIOLOGY 87 2: 371-377. 1997

Jolkkonen J, Halonen T, Jolkkonen E, Nissinen J, Pitkänen A. 1996. Seizure-induced damage to the hippocampus is prevented by modulation of the GABAergic system. NEUROREPORT 7: 2031-2035. 1996

Kiviranta T, Tuomisto L, Jolkkonen J, Airaksinen EM. 1996. Vasopressin in the cerebrospinal fluid of febrile children with or without seizures. BRAIN & DEVELOPMENT 18: 110-113. 1996

Åkerman KK, Jolkkonen J, Parviainen M, Penttilä I. 1996. Analysis of low-dose benzodiatzepines by HPLC with automated solid-phase extraction. CLINICAL CHEMISTRY 42 9: 1412-1416. 1996

Jolkkonen J, Jenner P, Marsden CD. 1995. L-DOPA reverses altered gene expression of substance P but not enkephalin in the caudate-putamen of common marmosets treated with MPTP. MOLECULAR BRAIN RESEARCH 32: 297-307. 1995

Rimon R, Lepola U, Jolkkonen J, Halonen T, Riekkinen P. 1995. Cerebrospinal fluid gamma-aminobutyric acid in patients with panic disorder BIOLOGICAL PSYCHIATRY 38 11: 737-741. 1995

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