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Sami Heikkinen

Sami Heikkinen

Tutkimusjohtaja

Biolääketieteen yksikkö, Lääketieteen laitos, Terveystieteiden tiedekunta

sami.heikkinen@uef.fi | 040 355 3393

Tiedot Julkaisut

Tutkimusryhmät

Geenien säätelyn genetiikka taudeissa - Heikkinen… 01.09.2017 -
Itä-Suomen Genomikeskus 02.03.2009 -
NPH and Early AD 01.01.2010 -

Julkaisut

77/79 kappaletta

Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci
de las Fuentes, Lisa; Schwander, Karen L; Brown, Michael R; Bentley, Amy R; Winkler, Thomas W; Sung, Yun Ju; Munroe, Patricia B; Miller, Clint L; Aschard, Hugo; Aslibekyan, Stella; Bartz, Traci M; Bielak, Lawrence F; Chai, Jin Fang; Cheng, Ching-Yu; Dorajoo, Rajkumar; Feitosa, Mary F; Guo, Xiuqing; Hartwig, Fernando P; Horimoto, Andrea; Kolčić, Ivana; Lim, Elise; Liu, Yongmei; Manning, Alisa K; Marten, Jonathan; Musani, Solomon K; Noordam, Raymond; Padmanabhan, Sandosh; Rankinen, Tuomo; Richard,. 2023. Frontiers in genetics. 14: . 1235337
Genetic variation is a key determinant of chromatin accessibility and drives differences in the regulatory landscape of C57BL/6J and 129S1/SvImJ mice
Mononen, Juho; Taipale, Mari; Malinen, Marjo; Velidendla, Bharadwaja; Niskanen, Einari; Levonen, Anna-Liisa; Ruotsalainen, Anna-Kaisa; Heikkinen, Sami. 2023. Nucleic acids research. [Epub ahead of print 28 Dec 2023]:
Expression profiles of small non-coding RNAs in breast cancer tumors characterize clinicopathological features and show prognostic and predictive potential
Kärkkäinen, Emmi; Heikkinen, Sami; Tengström, Maria; Kosma, Veli-Matti; Mannermaa, Arto; Hartikainen, Jaana M.. 2022. Scientific reports. 12: . 22614
FGF21 Contributes to Metabolic Improvements Elicited by Exenatide and Pioglitazone in Patients with Type 2 Diabetes
Samms, Ricardo J; Cheng, Christine C; Fourcaudot, Marcel; Heikkinen, Sami; Khattab, Ahmed; Adams, John; Cersosimo, Eugenio; Triplitt, Curtis; Puckett, Curtis; Tsintzas, Kostas; Adams, Andrew Charles; Abdul-Ghani, Muhammad A; DeFronzo, Ralph A; Norton, Luke. 2022. American journal of physiology : endocrinology and metabolism. 323: E123-E132
M1 Macrophages Induce Protumor Inflammation in Melanoma Cells through TNFR–NF-κB Signaling
Kainulainen, Kirsi; Takabe, Piia; Heikkinen, Sami; Aaltonen, Niina; de la Motte, Carol; Rauhala, Leena; Durst, Franziska C; Oikari, Sanna; Hukkanen, Taija; Rahunen, Eija; Ikonen, Ella; Hartikainen, Jaana M; Ketola, Kirsi; Pasonen-Seppänen, Sanna. 2022. Journal of investigative dermatology. 1412: 3041-3051.e10
Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries
Gharahkhani, Puya; Jorgenson, Eric; Hysi, Pirro; Khawaja, Anthony P; Pendergrass, Sarah; Han, Xikun; Ong, Jue Sheng; Hewitt, Alex W; Segrè, Ayellet V; Rouhana, John M; Hamel, Andrew R; Igo, Robert P; Choquet, Helene; Qassim, Ayub; Josyula, Navya S; Cooke Bailey, Jessica N; Bonnemaijer, Pieter W M; Iglesias, Adriana; Siggs, Owen M; Young, Terri L et al. [incl FinGen; Mannermaa, Arto; Heikkinen, Sami; Kosma, Veli-Matti]. 2021. Nature communications. 12: 1258
Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection
Zekavat, Seyedeh M.; Lin, Shu-Hong; Bick, Alexander G.; Liu, Aoxing; Paruchuri, Kaavya; Wang, Chen; Uddin, Md Mesbah; Ye, Yixuan; Yu, Zhaolong; Liu, Xiaoxi; Kamatani, Yoichiro; Bhattacharya, Romit; Pirruccello, James P.; Pampana, Akhil; Loh, Po-Ru; Kohli, Puja; McCarroll, Steven A.; Kiryluk, Krzysztof; Neale, Benjamin; Ionita-Laza, Iuliana et al. [incl. Mannermaa, Arto; Heikkinen, Sami; Kosma, Veli-Matti]. 2021. Nature medicine. 27: 1012-1024
Integrative analysis of liver-specific non-coding regulatory SNPs associated with the risk of coronary artery disease
Selvarajan, Ilakya; Toropainen, Anu; Garske, Kristina M.; López Rodríguez, Maykel; Ko, Arthur; Miao, Zong; Kaminska, Dorota; Õunap, Kadri; Örd, Tiit; Ravindran, Aarthi; Liu, Oscar H.; Moreau, Pierre R.; Jawahar Deen, Ashik; Männistö, Ville; Pan, Calvin; Levonen, Anna-Liisa; Lusis, Aldons J.; Heikkinen, Sami; Romanoski, Casey E.; Pihlajamäki, Jussi; Pajukanta, Päivi; Kaikkonen, Minna U.. 2021. American journal of human genetics. 108: 411-430
Lifetime risk of rheumatoid arthritis-associated interstitial lung disease in MUC5B mutation carriers
Palomäki, Antti; FinnGen Rheumatology Clinical Expert Group; Palotie, Aarno; Koskela, Jukka; Eklund, Kari K; Pirinen, Matti; FinnGen; Ripatti, Samuli; Laitinen, Tarja; Mars, Nina; [incl. collaborators Kosma, Veli-Matti; Mannermaa, Arto; Heikkinen, Sami]. 2021. Annals of the rheumatic diseases. 80: 1530-1536
Multi-ancestry genome-wide association study accounting for gene-psychosocial factor interactions identifies novel loci for blood pressure traits
Sun, Daokun; Richard, Melissa A.; Musani, Solomon K.; Sung, Yun Ju; Winkler, Thomas W.; Schwander, Karen; Chai, Jin Fang; Guo, Xiuqing; Kilpeläinen, Tuomas O.; Vojinovic, Dina; Aschard, Hugues; Bartz, Traci M.; Bielak, Lawrence F.; Brown, Michael R.; Chitrala, Kumaraswamy; Hartwig, Fernando P.; Horimoto, Andrea R.V.R.; Liu, Yongmei; Manning, Alisa K.; Noordam, Raymond et al. [incl. Heikkinen, Sami; Lakka, Timo]. 2021. HGG advances. 2: 100013
Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure
Wang, Heming; Noordam, Raymond; Cade, Brian E.; Schwander, Karen; Winkler, Thomas W.; Lee, Jiwon; Sung, Yun Ju; Bentley, Amy R.; Manning, Alisa K.; Aschard, Hugues; Kilpeläinen, Tuomas O.; Ilkov, Marjan; Brown, Michael R.; Horimoto, Andrea R.; Richard, Melissa; Bartz, Traci M.; Vojinovic, Dina; Lim, Elise; Nierenberg, Jovia L.; Liu, Yongmei et al. [incl. Heikkinen, Sami]. 2021. Molecular psychiatry. 26: 6293-6304
The debatable presence of PIWI-interacting RNAs in invasive breast cancer
Kärkkäinen, Emmi; Heikkinen, Sami; Tengström, Maria; Kosma, Veli-Matti; Mannermaa, Arto; Hartikainen, Jaana M. 2021. Cancer medicine. 10: 3593 - 3603
Toxicological transcriptome of human airway constructs after exposure to indoor air particulate matter: In search of relevant pathways of moisture damage-associated health effects
Nordberg, Maria-Elisa; Täubel, Martin; Heikkinen, Sami; Jalkanen, Kaisa; Köliö, Arto; Stranger, Marianne; Leppanen, Hanna; Hyvärinen, Anne; Huttunen, Kati. 2021. Environment international. 2022; 158: 106997
Vitamin D Treatment Sequence Is Critical for Transcriptome Modulation of Immune Challenged Primary Human Cells
Malmberg, Henna-Riikka; Hanel, Andrea; Taipale, Mari; Heikkinen, Sami; Carlberg, Carsten. 2021. Frontiers in immunology. 12: 754056
Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci
de Las Fuentes, Lisa; Sung, Yun Ju; Noordam, Raymond; Winkler, Thomas; Feitosa, Mary F; Schwander, Karen; Bentley, Amy R; Brown, Michael R; Guo, Xiuqing; Manning, Alisa; Chasman, Daniel I; Aschard, Hugues; Bartz, Traci M; Bielak, Lawrence F; Campbell, Archie; Cheng, Ching-Yu; Dorajoo, Rajkumar; Hartwig, Fernando P; Horimoto, A R V R; Li, Changwei et al [incl. Heikkinen, Sami; Lakka, Timo]. 2020. Molecular psychiatry. 2021; 26: 2111-2125
Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells
Bao, Erik L; Nandakumar, Satish K; Liao, Xiaotian; Bick, Alexander G; Karjalainen, J; Tabaka, Marcin; Gan, Olga I; Havulinna, Aki S; Kiiskinen, Tuomo TJ; Lareau, Caleb A; de Lapuente Portilla, Aitzkoa L; Li, Bo; Emdin, Connor; Codd, Veryan; Nelson, Christopher P; Walker, Christopher J; Churchhouse, Claire; de la Chapelle, Albert; Klein, Daryl E; et al. (incl. Kosma, V-M; Heikkinen, S; Mannermaa, A). 2020. Nature. 586: 769-775
MicroRNAs Associated With Biological Pathways of Left- And Right-sided Colorectal Cancer
Eneh, Stralina; Heikkinen, Sami; Hartikainen, Jaana M; Kuopio, Teijo; Mecklin, Jukka-Pekka; Kosma, Veli-Matti; Mannermaa, Arto. 2020. Anticancer research. 40: 3713-3722
The role of polygenic risk and susceptibility genes in breast cancer over the course of life
Mars, Nina; Widén, Elisabeth; Kerminen, Sini; Meretoja, Tuomo; Pirinen, Matti; Parolo, Pietro della Briotta; Palta, Priit; FinnGen, Palotie, Aarno; Kaprio, Jaakko; Joensuu, Heikki; Daly, Mark; Ripatti, Samuli [incl. Hiltunen, Mikko; Heikkinen, Sami; Julkunen, Valtteri; Kosma, Veli-Matti; Mannermaa, Arto; Kälviäinen, Reetta]. 2020. Nature communications. 11: 6383
A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure
Sung, Yun Ju; de Las Fuentes, Lisa; Winkler, Thomas W; Chasman, Daniel I; Bentley, Amy R; Kraja, Aldi T; Ntalla, Ioanna; Warren, Helen R; Guo, Xiuqing; Schwander, Karen; Manning, Alisa K; Brown, Michael R; Aschard, Hugues; Feitosa, Mary F; Franceschini, Nora; Lu, Yingchang; et al. (incl. Heikkinen, Sami; Kuusisto, Johanna; Laakso, Markku; Stancáková, Alena; Lakka, Timo A). 2019. Human molecular genetics. 28: 2615-2633
Abdominal adiposity and cardiometabolic risk factors in children and adolescents: a Mendelian randomization analysis
Viitasalo, A; Schnurr, TM; Pitkänen, N; Hollensted, M; Nielsen, TRH; Pahkala, K; Atalay, M; Lind, MV; Heikkinen, S; Frithioff-Bøjsøe, C; Fonvig, CE; Grarup, N; Kähönen, M; Carrasquilla, GD; Larnkjaer, A; Pedersen, O; Michaelsen, KF; Lakka, TA; Holm, JC; Lehtimäki, T; et al.. 2019. American journal of clinical nutrition. 110: 1079-1087
Genetic architecture of human plasma lipidome and its link to cardiovascular disease
Tabassum, Rubina; Ramo, Joel T; Ripatti, Pietari; Koskela, Jukka T; Kurki, Mitja; Karjalainen, Juha; Palta, Priit; Hassan, Shabbeer; Nunez-Fontarnau, Javier; Kiiskinen, Tuomo T J; Söderlund, Sanni; Matikainen, Niina; Gerl, Mathias J; Surma, Michal A; Klose, Christian; Stitziel, Nathan O; Laivuori, Hannele; Havulinna, Aki S; Service, Susan K; Salomaa, Veikko et al. (Incl Mannermaa, Arto; Heikkinen, Sami; Kosma, Veli-Matti; Soininen, Hilkka; Kälviäinen, Reetta). 2019. Nature communications. 10: 4329
HAS3-induced extracellular vesicles from melanoma cells stimulate IHH mediated c-Myc upregulation via the hedgehog signaling pathway in target cells
Arasu, UT; Deen, AJ; Pasonen-Seppänen, S; Heikkinen, S; Lalowski, M; Kärnä, R; Härkönen, K; Mäkinen, P; Lázaro-Ibáñez, E; Siljander, PR; Oikari, S; Levonen, AL; Rilla, K. 2019. Cellular and molecular life sciences. [Published: 09 December 2019]: 1-23
Multi-Ancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions
de Vries, PS; Brown, MR; Bentley, AR; Sung, YJ; Winkler, TW; Ntalla, I; Schwander, K; Kraja, AT; Guo, X; Franceschini, N; Cheng, CY; Sim, X; Vojinovic, D; Huffman, JE; Musani, SK; Li, C; Feitosa, MF; Richard, MA; Noordam, R; Aschard, H; et al. (Incl. Kuusisto, Johanna; Laakso, Markku; Lakka, Timo; Heikkinen, Sami). 2019. American journal of epidemiology. 188: 1033-1054
Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids
Bentley, AR; Sung, YJ; Brown, MR; Winkler, TW; Kraja, AT; Ntalla, I; Schwander, K; Chasman, DI; Lim, E; Deng, X; Guo, X; Liu, J; Lu, Y; Cheng, CY; Sim, X; Vojinovic, D; Lakka, TA; Heikkinen, S; Kuusisto, J; Laakso, M; et al. (incl. Laakso, Markku; Heikkinen, Sami; Kuusisto, Johanna; Lakka, Timo; Rauramaa, Rainer). 2019. Nature genetics. 51: 636-648
Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration
Noordam, R; Bos, MM; Wang, H; Winkler, TW; Bentley, AR; Kilpeläinen, TO; de Vries, PS; Sung, YJ; Schwander, K; Cade, BE; Manning, A; Aschard, H; Brown, MR; Chen, H; Franceschini, N; Musani, SK; Richard, M; Vojinovic, D; Aslibekyan, S; Bartz, TM; et al. (incl. Heikkinen, S). 2019. Nature communications. 10: 5121
Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity
Kilpeläinen, TO; Bentley, AR; Noordam, R; Sung, YJ; Schwander, K; Winkler, TW; Jakupovic, H; Chasman, DI; Manning, A; Ntalla, I; Aschard, H; Brown, MR; de Las Fuentes, L; Franceschini, N; Guo, X; Vojinovic, D; Aslibekyan, S; Feitosa, MF; Kho, M; Musani, SK; et al. [Incl. Lakka, Timo; Heikkinen, Sami; Kuusisto, Johanna; Laakso, Markku]. 2019. Nature communications. 10: 376
A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure
Sung, YJ; Winkler, TW; de Las Fuentes, L; Bentley, AR; Brown, MR; Kraja, AT; Schwander, K; Ntalla, I; Guo, X; Franceschini, N; Lu, Y; Cheng, CY; Sim, X; Vojinovic, D; Marten, J; Musani, SK; Li, C; Feitosa, MF; Kilpeläinen, TO; Richard, MA et al. (incl. Yaluri, Alena; Heikkinen, Sami; Kuusisto, Johanna; Laakso, Markku). 2018. American journal of human genetics. 102: 375-400
Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries
Feitosa, MF; Kraja, AT; Chasman, DI; Sung, YJ; Winkler, TW; Ntalla, I; Guo, X; Franceschini, N; Cheng, CY; Sim, X; Vojinovic, D; Marten, J; Musani, SK; Li, C; Bentley, AR; Brown, MR; Schwander, K; Richard, MA; Noordam, R; Aschard, H; et al. (incl. Laakso, Markku; Heikkinen, Sami; Kuusisto, Johanna; Lakka, Timo; Yaluri, Alena). 2018. PLoS ONE. 13: e0198166
The Diabetes Gene and Wnt Pathway Effector TCF7L2 Regulates Adipocyte Development and Function
Chen, Xi; Ayala, Iriscilla; Shannon, Chris; Fourcaudot, Marcel; Acharya, Nikhil K; Jenkinson, Christopher P; Heikkinen, Sami; Norton, Luke. 2018. Diabetes. 67: 554-568
Integration of VDR genome wide binding and GWAS genetic variation data reveals co-occurrence of VDR and NF-kappaB binding that is linked to immune phenotypes
Singh PK, van den Berg PR, Long MD, Vreugdenhil A, Grieshober L, Ochs-Balcom HM, Wang J, Delcambre S, Heikkinen S, Carlberg C, Campbell MJ, Sucheston-Campbell LE. 2017. Bmc genomics. 18: -
NRF2 regulates endothelial glycolysis and proliferation with miR-93 and mediates the effects of oxidized phospholipids on endothelial activation
Kuosmanen SM, Kansanen E, Kaikkonen MU, Sihvola V, Pulkkinen K, Jyrkkänen H-K, Tuoresmäki P, Hartikainen J, Hippeläinen M, Kokko H, Tavi P, Heikkinen S, Levonen A-M. 2017. Nucleic acids research. 2018; 46: 1124-1138
The Effects of Sequence Variation on Genome-wide NRF2 Binding - New Target Genes and Regulatory SNPs
Kuosmanen Suvi M, Viitala Sari, Laitinen Tuomo, Peräkylä Mikael, Pölönen Petri, Kansanen Emilia, Leinonen Hanna, Raju Suresh, Wienecke-Baldacchino Anke, Närvänen Ale, Poso Antti, Heinäniemi Merja, Heikkinen Sami, Levonen Anna-Liisa. 2016. Nucleic acids research. 44: 1760-1775
Gene Expression Mapping of Histone Deacetylases and Co-factors, and Correlation with Survival Time and 1H-HRMAS Metabolomic Profile in Human Gliomas
Dali-Youcef Nassim, Froelich Sébastian, Moussallieh Francois-Marie, Chibbaro Salvatore, Noël Georges, Namer Izzie J., Heikkinen Sami, Auwerx Johan. 2015. Scientific reports. : 10 pages
Patterns of Genome-Wide VDR Locations
Tuoresmäki Pauli, Väisänen Sami, Neme Antonio, Heikkinen Sami, Carlberg Carsten. 2014. PLoS ONE. 9: e96105
SUMOylation modulates the transcriptional activity of androgen receptor in a target gene and pathway selective manner
Sutinen Päivi, Malinen Marjo, Heikkinen Sami, Palvimo Jorma J. 2014. Nucleic acids research. 42: 8310-9
The mechanisms of genome-wide target gene regulation by TCF7L2 in liver cells
Norton Luke, Chen Xi, Fourcaudot Marcel, Acharya Nikhil K, DeFronzo Ralph A, Heikkinen Sami. 2014. Nucleic acids research. 42: 13646-13661
The transcriptional regulator BCL6 participates in the secondary gene regulatory response to vitamin D
Nurminen Veijo, Neme Antonio, Ryynänen Jussi, Heikkinen Sami, Seuter Sabine, Carlberg Carsten. 2014. Biochimica et biophysica acta: gene regulatory mechanisms. Epub ahead of print: -
Dynamics of 1&#945 ,25-dihydroxyvitamin D3-dependent chromatin accessibility of early vitamin D receptor target genes
Seuter S, Pehkonen P, Heikkinen S, Carlberg C. 2013. Biochimica et biophysica acta: international journal of biochemistry and biophysics. 1829: 1266-1275
Chromatin acetylation at transcription start sites and vitamin D receptor binding regions relates to effects of 1alfa,25-dihydroxyvitamin D3 and histone deacetylase inhibitors on gene expression
Seuter S, Heikkinen S, Carlberg C. 2012. Nucleic acids research. -: -
Genome-wide landscape of liver X receptor chromatin binding and gene regulation in human macrophages
Pehkonen P, Welter-Stahl L, Diwo J, Ryynänen J, Wienecke-Baldacchino A, Heikkinen S, Treuter E, Steffensen K, Carlberg C. 2012. Bmc genomics. 13: -
Proto-oncogene PIM-1 is a novel estrogen receptor target associating with high grade breast tumors
Malinen M, Jääskeläinen T, Pelkonen M, Heikkinen S, Väisänen S, Kosma VM, Nieminen K, Mannermaa A, Palvimo JJ. 2012. Molecular and cellular endocrinology. 2013; 365: 270-276
The First Genome-wide View of Vitamin D Receptor Locations and Their Mechanistic Implications
Carlberg C, Seuter S, Heikkinen S. 2012. Anticancer research. 32: 271-282
The activation of hepatic and muscle polyamine catabolism improves glucose homeostasis
Koponen T, Cerrada-Gimenez M, Pirinen E, Hohtola E, Paananen J, Vuohelainen S, Tusa M, Pirnes-Karhu S, Heikkinen S, Virkamäki A, Uimari A, Alhonen L, Laakso M.. 2012. Amino acids. 42: 427-440
The gene for the transcription factor BHLHE40/DEC1/stra13 is a dynamically regulated primary target of the vitamin D receptor
Seuter S, Pehkonen P, Heikkinen S, Carlberg C. 2012. Journal of steroid biochemistry and molecular biology. online: -
Nuclear hormone 1&#945 ,25-dihydroxyvitamin D3 elicits a genome-wide shift in the locations of VDR chromatin occupancy
Heikkinen Sami, Väisänen Sami, Pehkonen Petri, Seuter Sabine, Benes Vladimir, Carlberg Carsten. 2011. Nucleic acids research. 39: 9181-9193
Activated polyamine catabolism leads to low cholesterol levels by enhancing bile acid synthesis
Pirinen E, Gylling H, Itkonen P, Yaluri N, Heikkinen S, Pietilä M, Kuulasmaa T, Tusa M, Cerrada-Gimenez M, Pihlajamäki J, Alhonen L, Jänne J, Miettinen TA & Laakso M. 2010. Amino acids. 38: 549-560
Partial hexokinase II knocout results in acute ischemia-reperfusion damage in skeletal muscle of male, but not female, mice
Smeele KM, Eerbeek O, Koeman A, Bezemer R, Ince C, Heikkinen S, Laakso M, de Haan A, Schaart G, Drost MR, et al. 2010. Pflugers archiv: european journal of physiology. 459: 705-712
The Down-regulation of the Human MYC Gene by the Nuclear Hormone 1&#945 ,25-dihydroxyvitamin D3 is Associated with Cycling of Corepressors and Histone Deacetylases
Sari Toropainen, Sami Väisänen, Sami Heikkinen,Carsten Carlberg. 2010. Journal of molecular biology. 400: 284-294
Enhanced polyamine catabolism alters homeostatic control of white adipose tissue mass, energy expenditure, and glucose metabolism
Pirinen E, Kuulasmaa T, Pietilä M, Heikkinen S, Tusa M, Itkonen P, Boman S, Skommer J, Virkamäki A, Hohtola E, Kettunen M, Fatrai S, Kansanen E, Koota S, Niiranen K, Parkkinen J, Levonen A-L, Ylä-Herttuala S, Hiltunen JK, Alhonen L, Smith U, Jänne J. 2007. Molecular and cellular biology. 27: 4953-4967
PPARgamma in human and mouse physiology
Heikkinen S, Auwerx J, Argmann CA. 2007. Biochimica et biophysica acta: molecular and cell biology of lipids. 1771: 999-1013
Phosphorylation barriers to skeletal and cardiac muscle glucose uptakes in high-fat-fed mice. Studies in mice with a 50 % reduction of hexokinase II
Fueger PT, Lee-Young RS, Shearer J, Bracy DP, Heikkinen S, Laakso M, Rottman JN, Wasserman DH. 2007. Diabetes. 56: 2476-2484
Systematic gene expression mapping clusters nuclear receptors according to their function in the brain
Gofflot F, Chartoire N, Vasseur L, Heikkinen S, Dembele D, Le Merrer J, Auwerx J. 2007. Cell. 131: 405-418
Mice with targeted disruption of spermidine/spermine N1-acetyltransferese gene maintain nearly normal tissue polyamine homeostasis but show signs of insulin resistance upon aging
Niiranen K, Keinänen TA, Pirinen E, Heikkinen S, Tusa M, Fatrai S, Suppola S, Pietilä M, Uimari A, Laakso M, Alhonen L, Jänne J. 2006. Journal of cellular and molecular medicine. 10: 933-945
Polyamine-regulated unproductive splicing and translation of spermidine/spermine N1 -acetyltransferase
Hyvönen MT, Uimari A, Keinänen TA, Heikkinen S, Pellinen R, Wahlfors T, Korhonen A, Närvänen A, Wahlfors J, Alhonen L, Jänne J. 2006. RNA. 12: 1569-1582
Transcriptional targeting of virus-mediated gene transfer by the human hexokinase II promoter
Määttä A-M, Korja S, Venhoranta H, Hakkarainen T, Pirinen E, Heikkinen S, Pellinen R, Mäkinen K, Wahlfors J. 2006. International journal of molecular medicine. 18: 901-908
Type I interferon response against viral and non-viral gene transfer in human tumor and primary cell lines
Rautsi O, Lehmusvaara S, Salonen T, Häkkinen K, Sillanpää M, Hakkarainen T, Heikkinen S, Vähäkangas E, Ylä-Herttuala S, Hinkkanen A, Julkunen I, Wahlfors J, Pellinen R. 2006. Journal of gene medicine. 9: 122-135
Hexokinase II protein content is a determinant of exercise endurance capacity in the mouse
Fueger PT, Shearer J, Krueger TM, Posey KA, Bracy DP, Heikkinen S, Laakso M, Rottman JN, Wasserman DH. 2005. Journal of physiology: london. 566: 533-541
The Tenth Annual Post-Graduate Symposium of the A.I. Virtanen Institute Graduate School. AIVI Winter School 2005. Abstracts
Keinänen R, Heikkinen S, Huttunen J, Koskinen R, Mäntylä T, Peltonen H. 2005. Kuopion yliopiston julkaisuja G.- A.I. Virtanen -instituutti. . -
Analysis of the human hexokinase II promoter in vivo: lack of insulin response within 4.0 kb
Pirinen E, Heikkinen S, Malkki M, Deep SS, Jänne J, Laakso M. 2004. BIOCHIMICA ET BIOPHYSICA ACTA - GENE STRUCTURE AND EXPRESSION. 1676: 149-154
Glucose Metabolism in Heterozygous Hexokinase II Knock-out Mice
Heikkinen S. 2004. Kuopion yliopiston julkaisuja G.- A.I. Virtanen -instituutti
Hexokinase II partial knockout impairs exercise-stimulated glucose uptake in oxidative muscles of mice
Fueger PT, Heikkinen S, Bracy DP, Malabanan CM, Pencek RR, Laakso M, Wasserman DH. 2003. American journal of physiology : endocrinology and metabolism. 285: E958-E963
Mutations in the cardiac myosin-binding protein C gene are the predominant cause of familial hypertrophic cardiomyopathy in eastern Finland
Jääskeläinen P, Kuusisto J, Miettinen R, Kärkkäinen P, Kärkkäinen S, Heikkinen S, Peltola P, Pihlajamäki J, Vauhkonen I, Laakso M. 2002. Journal of molecular medicine: jmm. 80: 412-422
Concurrent overexpression of ornithine decarboxylase and spermidine/spermine N1-acetyltransferase further accelerates the catabolism of hepatic polyamines in transgenic mice
Suppola S, Heikkinen S, Parkkinen JJ, Uusi-Oukari M, Korhonen V-P, Keinänen T, Alhonen L, Jänne J. 2001. Biochemical journal. 358: 343-348
Mouse hexokinase II gene: structure, cDNA, promoter analysis, and expression pattern
Heikkinen S, Suppola S, Malkki M, Deeb SS, Jänne J, Laakso M. 2000. Mammalian genome. 11: 91-96
Hexokinase II-deficient mice: prenatal death of homozygotes without disturbances in glucose tolerance in heterozygotes
Heikkinen S, Pietilä M, Halmekytö M, Suppola S, Pirinen E, Deeb SS, Jänne J, Laakso M. 1999. Journal of biological chemistry. 274: 22517-22523
The codon 64 polymorphism of the beta3-adrenergic receptor gene is not associated with coronary heart disease or insulin resistance in nondiabetic subjects and non-insulin-dependent diabetic patients
Pulkkinen A, Kareinen A, Saarinen L, Heikkinen S, Lehto S, Laakso M. 1999. Metabolism: clinical and experimental. 48: 853-856
Different regulation of free fatty acid levels and glucose oxidation by the Trp64Arg polymorphism of the beta3-adrenergic receptor gene and the promoter variant (A-3826G) of the uncoupling protein 1 gene in familial combined hyperlipidemia
Pihlajamäki J, Rissanen J, Valve R, Heikkinen S, Karjalainen L, Laakso M. 1998. Metabolism: clinical and experimental. 47: 1397-1402
Glucokinase gene islet promoter region variant (G->A) at nucleotide -30 is not associated with reduced insulin secretion in Finns
Rissanen J, Saarinen L, Heikkinen S, Kekäläinen P, Mykkänen L, Kuusisto J, Deeb SS, Laakso M. 1998. Diabetes care. 21: 1194-1197
Synergistic effect of polymorphisms in uncoupling protein 1 and beta3-adrenergic receptor genes on basal metabolic rate in obese Finns
Valve R, Heikkinen S, Rissanen A, Laakso M, Uusitupa M. 1998. Diabetologia. 41: 357-361
Variants of the fatty acid-binding protein 2 gene are not associated with coronary heart disease in nondiabetic subjects and in patients with NIDDM
Saarinen L, Pulkkinen A, Kareinen A, Heikkinen S, Lehto S, Laakso M. 1998. Diabetes care. 21: 849-850
Codon 54 polymorphism of the human intestinal fatty acid binding protein 2 gene is associated with dyslipidemias but not with insulin resistance in patients with familial combined hyperlipidemia
Pihlajamäki J, Rissanen J, Heikkinen S, Karjalainen L, Laakso M. 1997. Arteriosclerosis, thrombosis, and vascular biology. 17: 1039-1044
New variants in the glycogen synthase gene (GIn71His, Met416Val) in patients with NIDDM from eastern Finland
Rissanen J, Pihlajamäki J, Heikkinen S, Kekäläinen P, Mykkänen L, Kuusisto J, Kolle A, Laakso M. 1997. Diabetologia. 40: 1313-1319
Polymorphism of the Beta3-adrenergic receptor gene affects basal metabolic rate in obese Finns
Sipiläinen R, Uusitupa M, Heikkinen S, Rissanen A, Laakso M. 1997. Diabetes. 46: 77-80
The ala54thr polymorphism of the fatty acid binding protein 2 gene does not influence insulin sensitivity in Finnish nondiabetic and NIDDM subjects
Rissanen J, Pihlajamäki J, Heikkinen S, Kekäläinen P, Kuusisto J, Laakso M. 1997. Diabetes. 46: 711-712
The trp64arg polymorphism of the beta3-adrenergic receptor gene
Rissanen J, Kuopusjärvi M, Pihlajamäki J, Sipiläinen R, Heikkinen S, Vanhala M, Kekäläinen P, Kuusisto J, Laakso M. 1997. Diabetes care. 20: 1319-1323
Threonine allele in codon 54 of the fatty acid binding protein 2 gene does not modify the fatty acid composition of serum lipids in obese subjects
Vidgren HM, Sipiläinen RH, Heikkinen S, Laakso M, Uusitupa MIJ. 1997. European journal of clinical investigation. 27: 405-408
Variants in the human intestinal fatty acid binding protein 2 gene in obese subjects
Sipiläinen R, Uusitupa M, Heikkinen S, Rissanen A, Laakso M. 1997. Journal of clinical endocrinology and metabolism. 82: 2629-2632

University of Eastern Finland Joensuu, Kuopio © University of Eastern Finland

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Näytä asetukset

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Tarkenna hakuasi

Sami Heikkinen

Tutkimusryhmät

Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci

Genetic variation is a key determinant of chromatin accessibility and drives differences in the regulatory landscape of C57BL/6J and 129S1/SvImJ mice

Expression profiles of small non-coding RNAs in breast cancer tumors characterize clinicopathological features and show prognostic and predictive potential

FGF21 Contributes to Metabolic Improvements Elicited by Exenatide and Pioglitazone in Patients with Type 2 Diabetes

M1 Macrophages Induce Protumor Inflammation in Melanoma Cells through TNFR–NF-κB Signaling

Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries

Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection

Integrative analysis of liver-specific non-coding regulatory SNPs associated with the risk of coronary artery disease

Lifetime risk of rheumatoid arthritis-associated interstitial lung disease in MUC5B mutation carriers

Multi-ancestry genome-wide association study accounting for gene-psychosocial factor interactions identifies novel loci for blood pressure traits

Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure

The debatable presence of PIWI-interacting RNAs in invasive breast cancer

Toxicological transcriptome of human airway constructs after exposure to indoor air particulate matter: In search of relevant pathways of moisture damage-associated health effects

Vitamin D Treatment Sequence Is Critical for Transcriptome Modulation of Immune Challenged Primary Human Cells

Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci

Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells

MicroRNAs Associated With Biological Pathways of Left- And Right-sided Colorectal Cancer

The role of polygenic risk and susceptibility genes in breast cancer over the course of life

A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure

Abdominal adiposity and cardiometabolic risk factors in children and adolescents: a Mendelian randomization analysis

Genetic architecture of human plasma lipidome and its link to cardiovascular disease

HAS3-induced extracellular vesicles from melanoma cells stimulate IHH mediated c-Myc upregulation via the hedgehog signaling pathway in target cells

Multi-Ancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions

Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids

Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration

Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity

A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure

Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries

The Diabetes Gene and Wnt Pathway Effector TCF7L2 Regulates Adipocyte Development and Function

Integration of VDR genome wide binding and GWAS genetic variation data reveals co-occurrence of VDR and NF-kappaB binding that is linked to immune phenotypes

NRF2 regulates endothelial glycolysis and proliferation with miR-93 and mediates the effects of oxidized phospholipids on endothelial activation

The Effects of Sequence Variation on Genome-wide NRF2 Binding - New Target Genes and Regulatory SNPs

Gene Expression Mapping of Histone Deacetylases and Co-factors, and Correlation with Survival Time and 1H-HRMAS Metabolomic Profile in Human Gliomas

Patterns of Genome-Wide VDR Locations

SUMOylation modulates the transcriptional activity of androgen receptor in a target gene and pathway selective manner

The mechanisms of genome-wide target gene regulation by TCF7L2 in liver cells

The transcriptional regulator BCL6 participates in the secondary gene regulatory response to vitamin D

Dynamics of 1&#945 ,25-dihydroxyvitamin D3-dependent chromatin accessibility of early vitamin D receptor target genes

Chromatin acetylation at transcription start sites and vitamin D receptor binding regions relates to effects of 1alfa,25-dihydroxyvitamin D3 and histone deacetylase inhibitors on gene expression

Genome-wide landscape of liver X receptor chromatin binding and gene regulation in human macrophages

Proto-oncogene PIM-1 is a novel estrogen receptor target associating with high grade breast tumors

The First Genome-wide View of Vitamin D Receptor Locations and Their Mechanistic Implications

The activation of hepatic and muscle polyamine catabolism improves glucose homeostasis

The gene for the transcription factor BHLHE40/DEC1/stra13 is a dynamically regulated primary target of the vitamin D receptor

Nuclear hormone 1&#945 ,25-dihydroxyvitamin D3 elicits a genome-wide shift in the locations of VDR chromatin occupancy

Activated polyamine catabolism leads to low cholesterol levels by enhancing bile acid synthesis

Partial hexokinase II knocout results in acute ischemia-reperfusion damage in skeletal muscle of male, but not female, mice

The Down-regulation of the Human MYC Gene by the Nuclear Hormone 1&#945 ,25-dihydroxyvitamin D3 is Associated with Cycling of Corepressors and Histone Deacetylases

Enhanced polyamine catabolism alters homeostatic control of white adipose tissue mass, energy expenditure, and glucose metabolism

PPARgamma in human and mouse physiology

Phosphorylation barriers to skeletal and cardiac muscle glucose uptakes in high-fat-fed mice. Studies in mice with a 50 % reduction of hexokinase II

Systematic gene expression mapping clusters nuclear receptors according to their function in the brain

Mice with targeted disruption of spermidine/spermine N1-acetyltransferese gene maintain nearly normal tissue polyamine homeostasis but show signs of insulin resistance upon aging

Polyamine-regulated unproductive splicing and translation of spermidine/spermine N1 -acetyltransferase

Transcriptional targeting of virus-mediated gene transfer by the human hexokinase II promoter

Type I interferon response against viral and non-viral gene transfer in human tumor and primary cell lines

Hexokinase II protein content is a determinant of exercise endurance capacity in the mouse

The Tenth Annual Post-Graduate Symposium of the A.I. Virtanen Institute Graduate School. AIVI Winter School 2005. Abstracts

Analysis of the human hexokinase II promoter in vivo: lack of insulin response within 4.0 kb

Glucose Metabolism in Heterozygous Hexokinase II Knock-out Mice

Hexokinase II partial knockout impairs exercise-stimulated glucose uptake in oxidative muscles of mice

Mutations in the cardiac myosin-binding protein C gene are the predominant cause of familial hypertrophic cardiomyopathy in eastern Finland

Concurrent overexpression of ornithine decarboxylase and spermidine/spermine N1-acetyltransferase further accelerates the catabolism of hepatic polyamines in transgenic mice

Mouse hexokinase II gene: structure, cDNA, promoter analysis, and expression pattern

Hexokinase II-deficient mice: prenatal death of homozygotes without disturbances in glucose tolerance in heterozygotes

The codon 64 polymorphism of the beta3-adrenergic receptor gene is not associated with coronary heart disease or insulin resistance in nondiabetic subjects and non-insulin-dependent diabetic patients

Different regulation of free fatty acid levels and glucose oxidation by the Trp64Arg polymorphism of the beta3-adrenergic receptor gene and the promoter variant (A-3826G) of the uncoupling protein 1 gene in familial combined hyperlipidemia

Glucokinase gene islet promoter region variant (G->A) at nucleotide -30 is not associated with reduced insulin secretion in Finns

Synergistic effect of polymorphisms in uncoupling protein 1 and beta3-adrenergic receptor genes on basal metabolic rate in obese Finns

Variants of the fatty acid-binding protein 2 gene are not associated with coronary heart disease in nondiabetic subjects and in patients with NIDDM

Codon 54 polymorphism of the human intestinal fatty acid binding protein 2 gene is associated with dyslipidemias but not with insulin resistance in patients with familial combined hyperlipidemia

New variants in the glycogen synthase gene (GIn71His, Met416Val) in patients with NIDDM from eastern Finland

Polymorphism of the Beta3-adrenergic receptor gene affects basal metabolic rate in obese Finns

The ala54thr polymorphism of the fatty acid binding protein 2 gene does not influence insulin sensitivity in Finnish nondiabetic and NIDDM subjects

The trp64arg polymorphism of the beta3-adrenergic receptor gene

Threonine allele in codon 54 of the fatty acid binding protein 2 gene does not modify the fatty acid composition of serum lipids in obese subjects

Variants in the human intestinal fatty acid binding protein 2 gene in obese subjects