Steroid Receptor Research Center

Tarkenna hakuasi

Tutkimusryhmä

01.01.2019 -

Biolääketieteen yksikkö, Lääketieteen laitos, Terveystieteiden tiedekunta

Tiedot Julkaisut

Tutkimme steroidihormonireseptorien merkitystä ja toimintaa etenkin kromatiinin ja transkription säätelyssä, sekä niiden roolia lääkeresistenssin muodostumisessa hormonipohjaisissa syövissä, etenkin eturauhassyövässä.

Steroidireseptorien tutkimuskeskuksessa toimii viisi tutkimusryhmää, joita johtaa Prof. Jorma Palvimo, Dos. Leena Latonen, Dos. Einari Niskanen, Akatemiatutkija Kirsi Ketola ja Akatemiatutkija Ville Paakinaho.

https://www.uef.fi/fi/artikkeli/steroidireseptorien-tutkimuskeskus-yhdistaa-nuoria-huippututkijoita

Julkaisut

109 kappaletta

A Multi-Stain Breast Cancer Histological Whole-Slide-Image Data Set from Routine Diagnostics
Weitz, Philippe; Valkonen, Masi; Solorzano, Leslie; Carr, Circe; Kartasalo, Kimmo; Boissin, Constance; Koivukoski, Sonja; Kuusela, Aino; Rasic, Dusan; Feng, Yanbo; Sinius Pouplier, Sandra; Sharma, Abhinav; Ledesma Eriksson, Kajsa; Latonen, Leena; Laenkholm, Anne-Vibeke; Hartman, Johan; Ruusuvuori, Pekka; Rantalainen, Mattias. 2023. Scientific data. 10: . 562
Complementary analysis of proteome‐wide proteomics reveals changes in RNA binding protein‐profiles during prostate cancer progression
Aikio, Erika; Koivukoski, Sonja; Kallio, Elina; Sadeesh, Nithin; Niskanen, Einari A; Latonen, Leena. 2023. Cancer reports. [First published: 17 August 2023]: 1-13
Deformation equivariant cross-modality image synthesis with paired non-aligned training data
Honkamaa, Joel; Khan, Umair; Koivukoski, Sonja; Valkonen, Mira; Latonen, Leena; Ruusuvuori, Pekka; Marttinen, Pekka. 2023. Medical image analysis. 90:
Dynamic switching of transcriptional regulators between two distinct low-mobility chromatin states
Wagh, Kaustubh; Stavreva, Diana A.; Jensen, Rikke A. M.; Paakinaho, Ville; Fettweis, Gregory; Schiltz, R. Louis; Wüstner, Daniel; Mandrup, Susanne; Presman, Diego M.; Upadhyaya, Arpita; Hager, Gordon L.. 2023. Science advances. 9: . ade1122
Identification of long noncoding RNAs with aberrant expression in prostate cancer metastases
Sattari, Mina; Kohvakka, Annika; Moradi, Elaheh; Rauhala, Hanna; Urhonen, Henna; Isaacs, William B; Nykter, Matti; Murtola, Teemu J; Tammela, Teuvo L. J.; Latonen, Leena; Bova, G. Steven; Kesseli, Juha; Visakorpi, Tapio. 2023. Endocrine-related cancer. 30:
International Online Team-Based Learning in Higher Education of Biomedicine - Evaluation by Learning Analytics
Mairinoja, Laura; López-Pernas, Sonsoles; Elmoazen, Ramy; Niskanen, Einari A.; Kuningas, Tiina; Wärri, Anni; Saqr, Mohammed; Strauss, Leena. Teoksessa: Elmoazen, Ramy; López-Pernas, Sonsoles; Misiejuk, Kamila; Khalil, Mohammad; Wasson, Barbara; Saqr, Mohammed(toim.) , 2023. Proceedings of the Technology-Enhanced Learning in Laboratories Workshop (TELL 2023). s. 49-60.
The effect of neural network architecture on virtual H&E staining: Systematic assessment of histological feasibility
Khan, Umair; Koivukoski, Sonja; Valkonen, Mira; Latonen, Leena; Ruusuvuori, Pekka. 2023. Patterns. 4:
Unstained Tissue Imaging and Virtual Hematoxylin and Eosin Staining of Histologic Whole Slide Images
Koivukoski, Sonja; Khan, Umair; Ruusuvuori, Pekka; Latonen, Leena. 2023. Laboratory investigation. 103:
Chemical Interrogation of Nuclear Size Identifies Compounds with Cancer Cell Line-Specific Effects on Migration and Invasion
Tollis, Sylvain; Rizzotto, Andrea; Pham, Nhan T; Koivukoski, Sonja; Sivakumar, Aishwarya; Shave, Steven; Wildenhain, Jan; Zuleger, Nikolaj; Keys, Jeremy T; Culley, Jayne; Zheng, Yijing; Lammerding, Jan; Carragher, Neil O; Brunton, Valerie G; Latonen, Leena; Auer, Manfred; Tyers, Mike; Schirmer, Eric C. 2022. Acs chemical biology. 17: 680-700
M1 Macrophages Induce Protumor Inflammation in Melanoma Cells through TNFR–NF-κB Signaling
Kainulainen, Kirsi; Takabe, Piia; Heikkinen, Sami; Aaltonen, Niina; de la Motte, Carol; Rauhala, Leena; Durst, Franziska C; Oikari, Sanna; Hukkanen, Taija; Rahunen, Eija; Ikonen, Ella; Hartikainen, Jaana M; Ketola, Kirsi; Pasonen-Seppänen, Sanna. 2022. Journal of investigative dermatology. 1412: 3041-3051.e10
Microglial amyloid beta clearance is driven by PIEZO1 channels
Jäntti, Henna; Sitnikova, Valeriia; Ishchenko, Yevheniia; Shakirzyanova, Anastasia; Giudice, Luca; Ugidos, Irene F; Gómez-Budia, Mireia; Korvenlaita, Nea; Ohtonen, Sohvi; Belaya, Irina; Fazaludeen, Feroze; Mikhailov, Nikita; Gotkiewicz, Maria; Ketola, Kirsi; Lehtonen, Šárka; Koistinaho, Jari; Kanninen, Katja M; Hernández, Damian; Pébay, Alice; Giugno, Rosalba; Korhonen, Paula; Giniatullin, Rashid; Malm, Tarja. 2022. Journal of neuroinflammation. 19: . 147
N/C Interactions Are Dispensable for Normal In Vivo Functioning of the Androgen Receptor in Male Mice
El Kharraz, Sarah; Dubois, Vanessa; Launonen, Kaisa-Mari; Helminen, Laura; Palvimo, Jorma J; Libert, Claude; Smeets, Elien; Moris, Lisa; Eerlings, Roy; Vanderschueren, Dirk; Helsen, Christine; Claessens, Frank. 2022. Endocrinology. 163: . bqac104
Nonmalignant AR-positive prostate epithelial cells and cancer cells respond differently to androgen
Kukkonen, Konsta; Autio-Kimura, Bryn; Rauhala, Hanna; Kesseli, Juha; Nykter, Matti; Latonen, Leena; Visakorpi, Tapio. 2022. Endocrine-related cancer. 29: 717–733
Nuclear Organization in Response to Stress: A Special Focus on Nucleoli
Batnasan, Enkhzaya; Koivukoski, Sonja; Kärkkäinen, Minttu; Latonen, Leena. Teoksessa: Kloc, Malgorzat ; Kubiak, Jacek Z(toim.) , 2022. Nuclear, Chromosomal, and Genomic Architecture in Biology and Medicine. s. 469-494. Springer
Nuclear size rectification: A potential new therapeutic approach to reduce metastasis in cancer
Schirmer, Eric C; Latonen, Leena; Tollis, Sylvain. 2022. Frontiers in cell and developmental biology. 10: . 1022723
Parvovirus nonstructural protein 2 interacts with chromatin-regulating cellular proteins
Mattola, Salla; Salokas, Kari; Aho, Vesa; Mäntylä, Elina; Salminen, Sami; Hakanen, Satu; Niskanen, Einari A.; Svirskaite, Julija; Ihalainen, Teemu O.; Airenne, Kari J.; Kaikkonen-Määttä, Minna; Parrish, Colin R.; Varjosalo, Markku; Vihinen-Ranta, Maija. 2022. PLoS pathogens. 18:
Spatial analysis of histology in 3D: quantification and visualization of organ and tumor level tissue environment
Ruusuvuori, Pekka; Valkonen, Masi; Kartasalo, Kimmo; Valkonen, Mira; Visakorpi, Tapio; Nykter, Matti; Latonen, Leena. 2022. Heliyon. 8:
miR-32 promotes MYC-driven prostate cancer
Scaravilli, Mauro; Koivukoski, Sonja; Gillen, Andrew; Bouazza, Aya; Ruusuvuori, Pekka; Visakorpi, Tapio; Latonen, Leena. 2022. Oncogenesis. 11: . 11
A systematic comparison of data- and knowledge-driven approaches to disease subtype discovery
Rintala, TJ; Federico, A; Latonen, L; Greco, D; Fortino, V. 2021. Briefings in bioinformatics. 22: bbab314
An intrinsically disordered region-mediated confinement state contributes to the dynamics and function of transcription factors
Garcia, David A; Johnson, Thomas A; Presman, Diego M; Fettweis, Gregory; Wagh, Kaustubh; Rinaldi, Lorenzo; Stavreva, Diana A; Paakinaho, Ville; Jensen, Rikke AM; Mandrup, Susanne; Upadhyaya, Arpita; Hager, Gordon L. 2021. Molecular cell. 81: 1484-1498
Androgen-Driven Fusion Genes and Chimeric Transcripts in Prostate Cancer
Scaravilli, Mauro; Koivukoski, Sonja; Latonen, Leena. 2021. Frontiers in cell and developmental biology. 9: 623809
BCOR modulates transcriptional activity of a subset of glucocorticoid receptor target genes involved in cell growth and mobility
Manjur, ABMK; Lempiäinen, JK; Malinen, M; Varjosalo, M; Palvimo, JJ; Niskanen, EA. 2021. Journal of steroid biochemistry and molecular biology. 210: 105873
Building a central repository landmarks a new era for artificial intelligence - assisted digital pathology development in Europe
Latonen, Leena; Ruusuvuori, Pekka. 2021. European journal of cancer. 150: 31-32
Chromatin-directed proteomics-identified network of endogenous androgen receptor in prostate cancer cells
Launonen, Kaisa-Mari; Paakinaho, Ville; Sigismondo, Gianluca; Malinen, Marjo; Sironen, Reijo; Hartikainen, Jaana M; Laakso, Hanna; Visakorpi, Tapio; Krijgsveld, Jeroen; Niskanen, Einari A; Palvimo, Jorma J. 2021. Oncogene. 40: 4567-4579
Combined glucocorticoid resistance and hyperlactatemia contributes to lethal shock in sepsis
Vandewalle, Jolien; Timmermans, Steven; Paakinaho, Ville; Vancraeynest, Lies; Dewyse, Liza; Vanderhaeghen, Tineke; Wallaeys, Charlotte; Van Wyngene, Lise; Van Looveren, Kelly; Nuyttens, Louise; Eggermont, Melanie; Dewaele, Sylviane; Velho, Tiago R; Moita, Luis F; Weis, Sebastian; Sponholz, Christoph; van Grunsven, Leo A; Dewerchin, Mieke; Carmeliet, Peter; De Bosscher, Karolien; et al.; [incl. Palvimo, Jorma]. 2021. Cell metabolism. 33: 1763-1776.e5
Convolutional Neural Network-Based Artificial Intelligence for Classification of Protein Localization Patterns
Liimatainen, Kaisa; Huttunen, Riku; Latonen, Leena; Ruusuvuori, Pekka. 2021. Biomolecules. 11: 264
Expression and ERG regulation of PIM kinases in prostate cancer
Eerola, Sini K; Kohvakka, Annika; Tammela, Teuvo LJ; Koskinen, Päivi J; Latonen, Leena; Visakorpi, Tapio. 2021. Cancer medicine. 10: 3427-3436
Genome-wide binding potential and regulatory activity of the glucocorticoid receptor's monomeric and dimeric forms
Johnson, Thomas A; Paakinaho, Ville; Kim, Sohyoung; Hager, Gordon L; Presman, Diego M. 2021. Nature communications. 12: 1987
Genome-wide crosstalk between steroid receptors in breast and prostate cancers
Paakinaho, Ville; Palvimo, Jorma J. 2021. Endocrine-related cancer. 28: R231-R250
Molecular and Functional Links between Neurodevelopmental Processes and Treatment-Induced Neuroendocrine Plasticity in Prostate Cancer Progression
Kaarijärvi, Roosa; Kaljunen, Heidi; Ketola, Kirsi. 2021. Cancers. 13: 692
Power-law behavior of transcription factor dynamics at the single-molecule level implies a continuum affinity model
Garcia, David A; Fettweis, Gregory; Presman, Diego M; Paakinaho, Ville; Jarzynski, Christopher; Upadhyaya, Arpita; Hager, Gordon L. 2021. Nucleic acids research. 49: 6605-6620
Proteomic Landscape of Prostate Cancer: The View Provided by Quantitative Proteomics, Integrative Analyses, and Protein Interactomes
Sadeesh, Nithin; Scaravilli, Mauro; Latonen, Leena. 2021. Cancers. 13: 4829
Reprogramming of glucocorticoid receptor function by hypoxia
Vanderhaeghen, Tineke; Timmermans, Steven; Watts, Deepika; Paakinaho, Ville; Eggermont, Melanie; Vandewalle, Jolien; Wallaeys, Charlotte; Van Wyngene, Lise; Van Looveren, Kelly; Nuyttens, Louise; Dewaele, Sylviane; Vanden Berghe, Joke; Lemeire, Kelly; De Backer, Joey; Dirkx, Laura; Vanden Berghe, Wim; Caljon, Guy; Ghesquière, Bart; De Bosscher, Karolien; Wielockx, Ben et al [incl. Palvimo, Jorma J]. 2021. Embo reports. 2022; 23: e53083
Single-cell ATAC and RNA sequencing reveal pre-existing and persistent cells associated with prostate cancer relapse
Taavitsainen, S.; Engedal, N.; Cao, S.; Handle, F.; Erickson, A.; Prekovic, S.; Wetterskog, D.; Tolonen, T.; Vuorinen, E. M.; Kiviaho, A.; Nätkin, R.; Häkkinen, T.; Devlies, W.; Henttinen, S.; Kaarijärvi, R.; Lahnalampi, M.; Kaljunen, H.; Nowakowska, K.; Syvälä, H.; Bläuer, M. et al [incl. Ketola, K.]. 2021. Nature communications. 12: 5307
Stress-induced nuclear condensation of NELF drives transcriptional downregulation
Rawat, Prashant; Boehning, Marc; Hummel, Barbara; Aprile-Garcia, Fernando; Pandit, Anwit S; Eisenhardt, Nathalie; Khavaran, Ashkan; Niskanen, Einari; Vos, Seychelle M; Palvimo, Jorma J; Pichler, Andrea; Cramer, Patrick; Sawarkar, Ritwick. 2021. Molecular cell. 81: 1013-1026
Subclone eradication analysis identifies targets for enhanced cancer therapy and reveals L1 retrotransposition as a dynamic source of cancer heterogeneity
Ketola, Kirsi; Kaljunen, Heidi; Taavitsainen, Sinja; Kaarijärvi, Roosa; Järvelä, Emmi; Rodriguez Martin, Bernardo; Haase, Kerstin; Woodcock, Dan J; Tubio, Jose; Wedge, David C; Nykter, Matti; Bova, G Steven. 2021. Cancer research. 81: 4901-4909
The androgen receptor depends on ligand-binding domain dimerization for transcriptional activation
El Kharraz, Sarah; Dubois, Vanessa; Royen, Martin E; Houtsmuller, Adriaan B; Pavlova, Ekatarina; Atanassova, Nina; Nguyen, Tien; Voet, Arnout; Eerlings, Roy; Handle, Florian; Prekovic, Stefan; Smeets, Elien; Moris, Lisa; Devlies, Wout; Ohlsson, Claes; Poutanen, Matti; Verstrepen, Kevin J; Carmeliet, Geert; Launonen, Kaisa-Mari; Helminen, Laura et al [incl. Palvimo, Jorma J]. 2021. Embo reports. 22: e52764
Virtual reality for 3D histology: multi-scale visualization of organs with interactive feature exploration
Liimatainen, Kaisa; Latonen, Leena; Valkonen, Masi; Kartasalo, Kimmo; Ruusuvuori, Pekka. 2021. Bmc cancer. 21: 1133
ZFP451-mediated SUMOylation of SATB2 drives embryonic stem cell differentiation
Antonio Urrutia, Gustavo; Ramachandran, Haribaskar; Cauchy, Pierre; Boo, Kyungjin; Ramamoorthy, Senthilkumar; Boller, Soeren; Dogan, Esen; Clapes, Thomas; Trompouki, Eirini; Torres-Padilla, Maria-Elena; Palvimo, Jorma J.; Pichler, Andrea; Grosschedl, Rudolf. 2021. Genes and development. 35: 1142-1160

Tarkenna hakuasi

Steroid Receptor Research Center

A Multi-Stain Breast Cancer Histological Whole-Slide-Image Data Set from Routine Diagnostics

Complementary analysis of proteome‐wide proteomics reveals changes in RNA binding protein‐profiles during prostate cancer progression

Deformation equivariant cross-modality image synthesis with paired non-aligned training data

Dynamic switching of transcriptional regulators between two distinct low-mobility chromatin states

Identification of long noncoding RNAs with aberrant expression in prostate cancer metastases

International Online Team-Based Learning in Higher Education of Biomedicine - Evaluation by Learning Analytics

The effect of neural network architecture on virtual H&E staining: Systematic assessment of histological feasibility

Unstained Tissue Imaging and Virtual Hematoxylin and Eosin Staining of Histologic Whole Slide Images

Chemical Interrogation of Nuclear Size Identifies Compounds with Cancer Cell Line-Specific Effects on Migration and Invasion

M1 Macrophages Induce Protumor Inflammation in Melanoma Cells through TNFR–NF-κB Signaling

Microglial amyloid beta clearance is driven by PIEZO1 channels

N/C Interactions Are Dispensable for Normal In Vivo Functioning of the Androgen Receptor in Male Mice

Nonmalignant AR-positive prostate epithelial cells and cancer cells respond differently to androgen

Nuclear Organization in Response to Stress: A Special Focus on Nucleoli

Nuclear size rectification: A potential new therapeutic approach to reduce metastasis in cancer

Parvovirus nonstructural protein 2 interacts with chromatin-regulating cellular proteins

Spatial analysis of histology in 3D: quantification and visualization of organ and tumor level tissue environment

miR-32 promotes MYC-driven prostate cancer

A systematic comparison of data- and knowledge-driven approaches to disease subtype discovery

An intrinsically disordered region-mediated confinement state contributes to the dynamics and function of transcription factors

Androgen-Driven Fusion Genes and Chimeric Transcripts in Prostate Cancer

BCOR modulates transcriptional activity of a subset of glucocorticoid receptor target genes involved in cell growth and mobility

Building a central repository landmarks a new era for artificial intelligence - assisted digital pathology development in Europe

Chromatin-directed proteomics-identified network of endogenous androgen receptor in prostate cancer cells

Combined glucocorticoid resistance and hyperlactatemia contributes to lethal shock in sepsis

Convolutional Neural Network-Based Artificial Intelligence for Classification of Protein Localization Patterns

Expression and ERG regulation of PIM kinases in prostate cancer

Genome-wide binding potential and regulatory activity of the glucocorticoid receptor's monomeric and dimeric forms

Genome-wide crosstalk between steroid receptors in breast and prostate cancers

Molecular and Functional Links between Neurodevelopmental Processes and Treatment-Induced Neuroendocrine Plasticity in Prostate Cancer Progression

Power-law behavior of transcription factor dynamics at the single-molecule level implies a continuum affinity model

Proteomic Landscape of Prostate Cancer: The View Provided by Quantitative Proteomics, Integrative Analyses, and Protein Interactomes

Reprogramming of glucocorticoid receptor function by hypoxia

Single-cell ATAC and RNA sequencing reveal pre-existing and persistent cells associated with prostate cancer relapse

Stress-induced nuclear condensation of NELF drives transcriptional downregulation

Subclone eradication analysis identifies targets for enhanced cancer therapy and reveals L1 retrotransposition as a dynamic source of cancer heterogeneity

The androgen receptor depends on ligand-binding domain dimerization for transcriptional activation

Virtual reality for 3D histology: multi-scale visualization of organs with interactive feature exploration

ZFP451-mediated SUMOylation of SATB2 drives embryonic stem cell differentiation