Johanna Matilainen ([email protected])
My PhD project research focuses on the roles of hepatocyte- and adipose tissue-derived extracellular vesicles in the development and progression of non-alcoholic fatty liver disease (NAFLD).
Johnson Lok ([email protected])
Building a Gut Microbiome Engineering Toolbox for In-Situ Therapeutic Treatments for Non-alcoholic Fatty Liver Disease (BestTreat) is a program funded by the European Commission which aims to develop novel diagnostic and therapeutic methods for NAFLD based on gut microbiota.
Aim of my study is to investigate the association between the NAFLD progression and alterations in gut microbiota and metabolites. Correlations between metagenomics, metabolomics, imaging data and other prognostic biomarkers for NAFLD are investigated to elucidate the mechanisms behind metabolic benefits conveyed by specific functional strains of the gut microbiota to the pathophysiology and pathogenesis of NAFLD. Metagenomic and metabolomic signatures of specific gut microbiota and metabolites will be used to develop novel microbiome-based disease prognostic biomarkers and therapeutic interventions for NAFLD.
Olli Kärkkäinen ([email protected])
I study the effects of different exposures, e.g. alcohol and drugs, to the metabolic processes in the body using metabolomics methods. My coal is to increase our understanding of disease processes to identify novel biomarkers of exposure and to identify new targets for treatment.