Immunology of type 1 diabetes

We study the immunological dysfunctions in human type 1 diabetes by utilizing samples from well-characterized Finnish clinical cohorts and by using state-of-the-art biomedical methodology

We analyze the phenotype and function of different immune cell subsets isolated from peripheral blood samples during the development of type 1 diabetes. Through collaboration with the national DIPP follow-up study (http://dipp.utu.fi) we are able to obtain samples from children with recent-onset T1D as well as autoantibody-positive at-risk subjects and age- and HLA-matched healthy control subjects. Our translational approach aims to provide insight to the immunological dysfunctions that lead from genetic susceptibility to autoimmunity and further to clinical type 1 diabetes in humans.