Immunology of type 1 diabetes
We study the immunological dysfunctions in human type 1 diabetes by utilizing samples from well-characterized Finnish clinical cohorts and by using state-of-the-art biomedical methodology
We analyze the phenotype and function of different immune cell subsets isolated from peripheral blood samples during the development of type 1 diabetes. Through collaboration with the national DIPP follow-up study (http://dipp.utu.fi) we are able to obtain samples from children with recent-onset T1D as well as autoantibody-positive at-risk subjects and age- and HLA-matched healthy control subjects. Our translational approach aims to provide insight to the immunological dysfunctions that lead from genetic susceptibility to autoimmunity and further to clinical type 1 diabetes in humans.
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Keywords
Time period
01.08.2012 -
Group members - UEF
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Tuure Kinnunen Academy Research Fellow, School of Medicine, Institute of Clinical Medicine, Clinical Microbiology -
Emmi-Leena Ihantola Nuorempi tutkija, School of Medicine, Institute of Clinical Medicine, Clinical Microbiology
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Ilse Ekman Doctoral student, MSc, School of Medicine, Institute of Clinical Medicine, Clinical Microbiology
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Anna-Mari Schroderus Nuorempi tutkija, School of Medicine, Institute of Clinical Medicine, Clinical Microbiology
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Céline Vandamme Postdoctoral researcher, School of Medicine, Institute of Clinical Medicine, Clinical Microbiology