Transporter-Targeted Drug Delivery

The research group studies how transporter proteins can be utilized in order to target drugs to their site of action, which would improve their efficacy and safety.

Our research group is developing novel transporter-utilizing (pro)drugs to improve drug delivery into the brain across the blood-brain barrier (BBB) and within the brain. We also study how drugs can be targeted into the pancreas or solid tumors. We are interested to understand how (pro)drugs can be selectively targeted into different cell types (neurons, glial cells, cancer cells, beta-cells or activated immune cells) presenting inflammation, and how transporter expression can be selectively modulated in cancer cells in order to reverse chemoresistance of solid tumors. In addition, we are elucidating how inhibition of specific transporters can affect cancer cell proliferation or nutrient delivery into the brain or drug delivery into cancer cells.