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Transporter-Targeted Drug Delivery´s Profile image

Transporter-Targeted Drug Delivery

Research group
01.09.2012 -
School of Pharmacy, Faculty of Health Sciences

Leaders

Our research group studies how transporter proteins can be utilized in order to target drugs to their site of action, which would improve their efficacy and safety. We develop novel transporter-utilizing compounds and prodrugs that can release the active drug at their target site. More specifically we aim to:

1. Improve the drug delivery across the blood-brain barrier (BBB) and selectively into different cell types (neurons, astrocytes or microglia) within brain (intra-brain targeting)

2. Explore if dual targeting of LAT1-utilizing compounds into the brain and simultaneously into the pancreas (brain-pancreas axis) can have beneficial effects on the treatment of neurodegenerative diseases

3. Target chemotherapeutics (prodrugs or drug analogues) selectively into the cancer cells and inhibit specific transporter’s function to block nutrient delivery into the cancer cell or drug efflux out of the cancer cells (chemoresistance) to increase antiproliferative effects

We are also interested in how to modulate the expression of specific transporter’s expression or function to regulate nutrient or toxin uptake e.g., into the brain that can affect the progession of neurological diseases, or into specific cells, like cancer cells.

In our research group we focus on the journey of lifelong learning, although the scientific road can be a daily roll-a-coaster.

Read more about our scientific activities from our Word Press and Blogger pages:

https://sites.uef.fi/drug-targeting/

https://tmtdd.blogspot.com/

Our Research Projects

Methods

Vacancies

Postdoctoral Candidates
Unfortunately, we do not have currently any open positions for postdoctoral researchers. However, our group is happy to support and help in writing any candidate with a clear vision of the proposed project that could be funded by e.g., Marie Skłodowska-Curie Individual Fellowship, Academy of Finland Postdoctoral Fellowship, UEF Postdoctoral Fellowship, or any other grants from national or international foundations.

Topics for M.Sc. Thesis or Diploma Work in Pharmacy for ERASMUS students:

Funding

Keywords

Publications

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