Vascular Biology (Laakkonen)
Research group
01.09.2019 -
A.I. Virtanen Institute for Molecular Sciences, Faculty of Health Sciences
Leaders
From left to right: Miika Kiema, Emma Luoto, Heidi Pulkkinen, Henna Ilmonen and Johanna Laakkonen.
Our research group focuses on understanding vessel formation and remodelling in disease. Particularly, the role of cell-cell crosstalk, cell plasticity and angiocrine signaling are studied in disease progression. Based on the data, we develop new gene medicines for cardiovascular diseases.
Projects:
- Angiocrine signaling and vascular cell-cell crosstalk
- Disease mechanisms of venous malformations
- Disease mechanisms of ascending aortic aneurysms
- New gene medicines
News
-
Our research bulletin: Fibroblasts participate in the formation of vascular malformations – a potential new target for therapyOur research bulletin: Fibroblasts participate in the formation of vascular malformations – a potential new target for therapy
Cooperation
-
Cardiovascular Genomics (Kaikkonen lab) 01.09.2015 - -
Molecular Medicine 01.01.1995 - -
Heart surgery imaging 01.01.2022 - -
Biomedical Image Analysis 01.11.2016 - -
Ocular Drug Delivery group (ODD) 01.01.2010 -
Our cover image in a recent issue of Angiogenesis journal (y. 2021). In the image, you can see cells that have formed tubes (i.e. points of the star) mimicking blood vessel formation.
Keywords
Leaders
Senior Researchers
Doctoral Researchers
-
Miika Kiema
Doctoral ResearcherA.I. Virtanen Institute for Molecular Sciences, Faculty of Health Sciences -
Heidi Pulkkinen
Doctoral Researcher -
Heta Rasinkangas
Grant-funded ResearcherA.I. Virtanen Institute for Molecular Sciences, Faculty of Health Sciences
Supporting Staff
Other group members
-
Anna Ronkonen
Publications
7 items-
Capillary Dynamics Regulate Post-Ischemic Muscle Damage and Regeneration in Experimental Hindlimb Ischemia
Wirth, Galina; Juusola, Greta; Tarvainen, Santeri; Laakkonen, Johanna P.; Korpisalo, Petra; Ylä-Herttuala, Seppo. 2023. Cells. 12: -
Dissecting the polygenic basis of atherosclerosis via disease-associated cell state signatures
Örd, Tiit; Lönnberg, Tapio; Nurminen, Valtteri; Ravindran, Aarthi; Niskanen, Henri; Kiema, Miika; Õunap, Kadri; Maria, Maleeha; Moreau, Pierre R; Mishra, Pashupati P; Palani, Senthil; Virta, Jenni; Liljenbäck, Heidi; Aavik, Einari; Roivainen, Anne; Ylä-Herttuala, Seppo; Laakkonen, Johanna P; Lehtimäki, Terho; Kaikkonen, Minna U. 2023. American journal of human genetics. 110: 722-740 -
ErbB signalling is a potential therapeutic target for vascular lesions with fibrous component
Jauhiainen, Suvi; Ilmonen, Henna; Vuola, Pia; Rasinkangas, Heta; Pulkkinen, Heidi H; Keränen, Sara; Kiema, Miika; Liikkanen, Jade J; Laham Karam, Nihay; Laidinen, Svetlana; Beter, Mustafa; Aavik, Einari; Lappalainen, Kimmo; Lohi, Jouko; Aronniemi, Johanna; Örd, Tiit; Kaikkonen, Minna U; Salminen, Päivi; Tukiainen, Erkki; Ylä-Herttuala, Seppo; Laakkonen, Johanna P. 2023. eLife. 12: -
Nondestructive Evaluation of Mechanical and Histological Properties of the Human Aorta With Near-Infrared Spectroscopy
Sarin, Jaakko K; Kiema, Miika; Luoto, Emma-Sofia; Husso, Annastiina; Hedman, Marja; Laakkonen, Johanna P; Torniainen, Jari. 2023. Journal of surgical research. 287: 82-89 -
SproutAngio: an open-source bioimage informatics tool for quantitative analysis of sprouting angiogenesis and lumen space
Beter, M; Abdollahzadeh, A; Pulkkinen, HH; Huang, H; Orsenigo, F; Magnusson, PU; Ylä-Herttuala, S; Tohka, J; Laakkonen, JP. 2023. Scientific reports. 13: . 7279 -
Large Vessel Cell Heterogeneity and Plasticity: Focus in Aortic Aneurysms
Jauhiainen, Suvi; Kiema, Miika; Hedman, Marja; Laakkonen, Johanna P. 2022. Arteriosclerosis, thrombosis, and vascular biology. 42: 811-818 -
Wall Shear Stress Predicts Media Degeneration and Biomechanical Changes in Thoracic Aorta
Kiema, Miika; Sarin, Jaakko K; Kauhanen, S Petteri; Torniainen, Jari; Matikka, Hanna; Luoto, Emma-Sofia; Jaakkola, Pekka; Saari, Petri; Liimatainen, Timo; Vanninen, Ritva; Ylä-Herttuala, Seppo; Hedman, Marja; Laakkonen, Johanna P. 2022. Frontiers in physiology. 13: . 934941