
Leaders
Group description
Selected, recent publications y.2020-
1) JAUHIAINEN S, Kiema M, Hedman M, Laakkonen JP. Large Vessel Cell Heterogeneity and Plasticity: Focus in Aortic Aneurysms. Arterioscler Thromb Vasc Biol. 2022 Jul;42(7):811-818. doi: 10.1161/ATVBAHA.121.316237. Epub 2022 May 19. PMID: 35587695.
2) KIEMA M, Sarin JK, Kauhanen SP, Torniainen J, Matikka H, Luoto ES, Jaakkola P, Saari P, Liimatainen T, Vanninen R, Ylä-Herttuala S, Hedman M, Laakkonen JP. Wall Shear Stress Predicts Media Degeneration and Biomechanical Changes in Thoracic Aorta. Front Physiol. 2022 Jul 7;13:934941.
3) PULKKINEN HH, Kiema M, Lappalainen JP, Toropainen A, Beter M, Tirronen A, Holappa L, Niskanen H, Kaikkonen MU, Ylä-Herttuala S, Laakkonen J.P. BMP6/TAZ-Hippo signaling modulates angiogenesis and endothelial cell response to VEGF. Angiogenesis 2021 Feb;24(1):129-144.
4) HSIN-FU LIU O, Kiema M, Beter M, Ylä-Herttuala S, Laakkonen JP, Kaikkonen MU. Hypoxia-Mediated Regulation of Histone Demethylases Affects Angiogenesis-Associated Functions in Endothelial Cells. Arterioscler Thromb Vasc Biol. 2020 Nov;40(11):2665-2677.
5) LAAKKONEN J.P., Ylä-Herttuala S. Chapter in book: Emerging technologies for heart diseases. Volume 2: Treatments for Myocardial Ischemia and Arrhythmias. 1st edition. Chapter: Gene and protein therapy approaches to cardiac neovascularization and protection from ischemia. Editor: Udi Nussinovitch. Elsevier Publishing Group. 2020.
6) TIRRONEN A, Downes NL, Huusko J, Laakkonen JP, Tuomainen T, Tavi P, Hedman M, Ylä-Herttuala S. The Ablation of VEGFR-1 Signaling Promotes Pressure Overload-Induced Cardiac Dysfunction and Sudden Death. Biomolecules 2021. Mar 17;11(3):452.
7) MOREAU PR, Bosch VM, Bouvy-Liivrand M, Õunap K, Örd T, Pulkkinen HH, Pölönen P, Heinäniemi M, Ylä-Herttuala S, Laakkonen JP, Linna-Kuosmanen S, Kaikkonen MU. Profiling of primary and mature miRNA expression in atherosclerosis associated cell types. Arterioscler Thromb Vasc Biol. 2021 Jul;41(7):2149-2167.
8) KERÄNEN S, Suutarinen S., Mallick R., Laakkonen J.P., Guo D., Pawlikowska L., Jahromi B.R., Rauramaa T., Ylä-Herttuala S., Marchuk D., Krings T., Koivisto T., Lawton M., Radovanovic I., Kim H., Faughnan M.E., Frösen J. Cyclo-oxygenase 2, a putative mediator of vessel remodeling, is expressed in the brain AVM vessels and associates with inflammation. Acta Neurochir (Wien) 2021 Jun 29. doi: 10.1007/s00701-021-04895-z. Online ahead of print.
9) MUSHIMIYIMANA I., Niskanen H., Beter M., Laakkonen J.P., Kaikkonen M.U., Ylä-Herttuala S., Laham-Karam N. Characterization of a functional endothelial super-enhancer that regulates ADAMTS18 and angiogenesis. Nucleic Acids Res. 2021 Jul 28:gkab633. doi: 10.1093/nar/gkab633. Epub ahead of print.
Cooperation
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Cardiovascular Genomics (Kaikkonen lab) 01.09.2015 -
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Molecular Medicine 01.01.1995 -
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Heart surgery imaging 01.01.2022 -
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Biomedical Image Analysis 01.11.2016 -
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Ocular Drug Delivery group (ODD) 01.01.2010 -

Our cover image in a recent issue of Angiogenesis journal (y. 2021). In the image, you can see cells that have formed tubes (i.e. points of the star) mimicking blood vessel formation.
Keywords
Leaders
Senior Researchers
Doctoral Researchers
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Miika Kiema
Doctoral ResearcherFaculty of Health Sciences, A.I. Virtanen Institute for Molecular Sciences -
Heidi Pulkkinen
Doctoral ResearcherFaculty of Health Sciences, A.I. Virtanen Institute for Molecular Sciences -
Henna Ilmonen
Doctoral ResearcherFaculty of Health Sciences, A.I. Virtanen Institute for Molecular Sciences
Other group members
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Heta Rasinkangas
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Emma-Sofia Luoto
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Akseli Kivistö-Rahnasto
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Mila Jäntti
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Liinu Kilpeläinen
Publications
22 items-
Characterization of a functional endothelial super-enhancer that regulates ADAMTS18 and angiogenesis
Mushimiyimana, I; Niskanen. H; Beter, M; Laakkonen, JP; Kaikkonen, MU; Ylä-Herttuala, S; Laham-Karam, N. 2021. Nucleic acids research. 49: 8078-8096 -
Cyclo-oxygenase 2, a putative mediator of vessel remodeling, is expressed in the brain AVM vessels and associates with inflammation
Keränen, Sara; Suutarinen, Santeri; Mallick, Rahul; Laakkonen, Johanna P.; Guo, Diana; Pawlikowska, Ludmila; Jahromi, Behnam Rezai; Rauramaa, Tuomas; Ylä-Herttuala, Seppo; Marchuk, Doug; Krings, Timo; Koivisto, Timo; Lawton, Michael; Radovanovic, Ivan; Kim, Helen; Faughnan, Marie E.; Frösen, Juhana. 2021. Acta neurochirurgica. 163: 2503-2514 -
Profiling of Primary and Mature miRNA Expression in Atherosclerosis Associated Cell Types
Moreau, PR; Tomas Bosch, V; Bouvy-Liivrand,M; Õunap, K; Örd, T; Pulkkinen, HH; Pölönen, P; Heinäniemi, M; Ylä-Herttuala, S; Laakkonen, JP; Linna-Kuosmanen, S; Kaikkonen, MU. 2021. Arteriosclerosis, thrombosis, and vascular biology. 41: 2149-2167 -
The Ablation of VEGFR-1 Signaling Promotes Pressure Overload-Induced Cardiac Dysfunction and Sudden Death
Tirronen, Annakaisa; Downes, Nicholas L; Huusko, Jenni; Laakkonen, Johanna P; Tuomainen, Tomi; Tavi, Pasi; Hedman, Marja; Ylä-Herttuala, Seppo. 2021. Biomolecules. 11: 452 -
BMP6/TAZ-Hippo signaling modulates angiogenesis and endothelial cell response to VEGF
Pulkkinen, H H; Kiema, M; Lappalainen, J P; Toropainen, A; Beter, M; Tirronen, A; Holappa, L; Niskanen, H; Kaikkonen, M U; Ylä-Herttuala, S; Laakkonen, Johanna P. 2020. Angiogenesis. 2021; 24: 12-144 -
Gene and protein therapy approaches to cardiac neovascularization and protection from ischemia
Laakkonen, Johanna P; Ylä-Herttuala, Seppo. Teoksessa: Nussinovitch, Udi(toim.) , 2020. Emerging Technologies for Heart Diseases. Volume 2: Treatments for Myocardial Ischemia and Arrhythmias. s. 649-663. Academic press -
Hypoxia-Mediated Regulation of Histone Demethylases Affects Angiogenesis-Associated Functions in Endothelial Cells
Hsin-Fu Liu, Oscar; Kiema, Miika; Beter, Mustafa; Ylä-Herttuala, Seppo; Laakkonen, Johanna P; Kaikkonen, Minna U. 2020. Arteriosclerosis, thrombosis, and vascular biology. 40: 2665-2677 -
Assessment of the Relaxation-Enhancing Properties of a Nitroxide-Based Contrast Agent TEEPO-Glc with In Vivo Magnetic Resonance Imaging
Soikkeli, Maiju; Kettunen, Mikko I; Nivajärvi, Riikka; Olsson, Venla; Rönkkö, Seppo; Laakkonen, Johanna P; Lehto, Vesa-Pekka; Kavakka, Jari; Heikkinen, Sami. 2019. Contrast media and molecular imaging. 2019: 5629597 -
Axon Guidance-Related Factor FLRT3 Regulates VEGF-Signaling and Endothelial Cell Function
Jauhiainen, Suvi; Laakkonen, Johanna P; Ketola, Kirsi; Toivanen, Pyry, I; Nieminen, Tina; Ninchoji, Takeshi; Levonen, Anna-Liisa; Kaikkonen, Minna U; Ylä-Herttuala, Seppo. 2019. Frontiers in physiology. 10: 224 -
Beyond endothelial cells: Vascular endothelial growth factors in heart, vascular anomalies and placenta
Laakkonen, Johanna P; Lähteenvuo, Johanna; Jauhiainen, Suvi; Heikura, Tommi; Ylä-Herttuala, Seppo. 2019. Vascular pharmacology. 112: 91-101