LC-MS metabolomics center
Leaders
Contact persons
The LC-MS Metabolomics Center is a service unit of Biocenter Kuopio operating at the School of Pharmacy, University of Eastern Finland, and part of the national Biocenter Finland research infrastructure network. The center provides comprehensive metabolomics and lipidomics analytical services and supports research throughout the entire workflow, from sample preparation to data interpretation.
The service portfolio includes analyses based on liquid chromatography (LC), gas chromatography (GC), and mass spectrometry (MS), as well as method development and validation, and biochemical and statistical interpretation of results. The measurement services are based on up-to-date, research-driven methodologies and cover both untargeted and targeted approaches. In addition, the center offers expert consultation and training services in analytical chemistry and metabolomics applications.
High-quality data, methodological reliability, and close collaboration with academic and industrial research partners are at the core of the center’s activities.
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Leaders
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Miia-Liisa Reponen
Senior Laboratory TechnicianSchool of Pharmacy, Faculty of Health Sciences -
Juulia Kuparinen
Laboratory AssistantSchool of Pharmacy, Faculty of Health Sciences
Contact persons
Researchers
Publications
56 items-
IFNγ alters the aberrant phenotype of α-synuclein–treated microglia reducing the detrimental impact of their secretome on dopaminergic neurons
Niskanen, Jonna; Hakosalo, Vili; Hämäläinen, Wilhelmiina; Kälvälä, Sara; Hyvönen, Mervi T; Zhang, Yinjia; Luk, Kelvin C; Koistinaho, Jari; Lehtonen, Marko; Goldsteins, Gundars; Albert, Katrina; Lehtonen, Šárka, 2026, Neuroscience, 603, 201-213. A1 Journal article (refereed), original research -
Metabolomic insights: LC–MS profiling of human placental tissue from SSRI-treated pregnancies
Itkonen, Anna; Kärkkäinen, Olli; Lehtonen, Marko; Sahlman, Heidi; Keski-Nisula, Leea; Rysä, Jaana, 2026, European journal of medical research, 31, 258. A1 Journal article (refereed), original research -
Plasma metabolomics and red blood cell fatty acid profiles in adolescent mental health
Piironen, Aino Kaisa; Afonin, Alexey M; Zarei, Iman; Koistinen, Ville; Lehtonen, Marko; Hämäläinen, Venla; Sala-Vila, Aleix; Lázaro, Iolanda; Julvez, Jordi; van Kamp, Irene; Kanninen, Katja M, 2026, Comprehensive psychoneuroendocrinology, 26, 100347. A1 Journal article (refereed), original research -
A new urinary biomarker reflecting the progesterone excretion pattern identified through serum steroid and urinary progesterone metabolite analysis during pro-oestrus and oestrus in female dogs (Canis familiaris)
Pennanen, Tia M; Häkkinen, Merja R; Juvonen, Risto O; Vepsäläinen, Jouko J; Auriola, Seppo; Viitala, Sari M, 2025, Animal reproduction science, 284, 108054. A1 Journal article (refereed), original research -
Amino acid prodrug of capsaicin improves pharmacokinetic properties in the mouse brain and pancreas
Tampio, Janne; Králová, Adéla; Riihioja, Sara; Pitkänen, Sofia; Markowicz-Piasecka, Magdalena; Ihamäki, Olli; Savolainen, Katja; Torunoglu, Sema T; Jalkanen, Aaro J; Lehtonen, Marko; Kauppinen, Anu; Rysä, Jaana; Huttunen, Kristiina M, 2025, European journal of pharmaceutics and biopharmaceutics, 214, 114797. A1 Journal article (refereed), original research -
Analysis of Methylated Quaternary Ammonium Compounds Using Hydrophilic Interaction Liquid Chromatography Combined With Mass Spectrometry
Zarei, Iman; Babu, Ambrin Farizah; Koistinen, Ville M; Tuomainen, Marjo; Kårlund, Anna; Haikonen, Retu; Lehtonen, Marko; Hanhineva, Kati, 2025, Mass spectrometry reviews, 45, 1, 107-119. A2 Review article, Literature review, Systematic review -
Effects of alcohol on the transcriptome, methylome, and metabolome of <i>in vitro</i> gastrulating human embryonic cells
Wallén, E.; Rämö, K.; Vehviläinen, J.; Sokka, J.; Lehtonen, M.; Otonkoski, T.; Trokovic, R.; Auvinen, P.; Kärkkäinen, O.; Kaminen-Ahola, N, 2025, Disease models and mechanisms, 18, 6, dmm052150. A1 Journal article (refereed), original research -
Harmonizing human plasma metabolite annotation with Plasma Benchmark
Koistinen, Ville; Meuronen, Topi; Keski-Rahkonen, Pekka; Salek, Reza; Savolainen, Otto; Ahmed, Hany; Brunius, Carl; Landberg, Rikard; Lehtonen, Marko; Auriola, Seppo; Scalbert, Augustin; Hanhineva, Kati, 2025, Nature metabolism, 7, 10, 1955-1957. B1 Non-refereed journal articles -
Inhibition of endocannabinoid hydrolases MAGL, FAAH and ABHD6 by AKU-005 reduces ex vivo cortical spreading depression
Brugia, Flavia; Ivanov, Konstantin; Aroviita, Auni; Giniatullina, Raisa; Lehtonen, Marko; Malm, Tarja; Savinainen, Juha; Giniatullin, Rashid; Della Pietra, Adriana, 2025, Journal of headache and pain, 26, 1, 85. A1 Journal article (refereed), original research -
Metabolic Alterations in Human Post-Mortem Frontal Cortex and Cerebrospinal Fluid Associated With High Levels of Nicotine Metabolite Cotinine
Masvosva, Wadzanai; Lehtonen, Marko; Martiskainen, Mika; Tiihonen, Jari; Karhunen, Pekka J.; Hanhineva, Kati; Rysä, Jaana; Kok, Eloise; Kärkkäinen, Olli, 2025, Addiction biology, 30, 6, e70064. A1 Journal article (refereed), original research