
Jarkko Rautio
Professor
Vice-Head of Department Professor of Pharmaceutical Chemistry, vice-head of the School of Pharmacy and director of the Doctoral Programme in Drug Research (DPDR).
Faculty of Health Sciences, School of Pharmacy
jarkko.rautio@uef.fi | +358 40 353 2791
My research is focused on the chemistry-based methods, especially prodrugs, in drug delivery and targeting. Much of the research is currently focusing on exploiting the body’s natural mechanisms for transporting nutrients, the LAT1 and GLUT1 proteins, for targeted drug delivery across the blood-brain barrier (BBB) and cancer cells that express these transporters.
Research groups
Publications
97 items-
Development of Lyophilised Eudragit® Retard Nanoparticles for the Sustained Release of Clozapine via Intranasal Administration
Lombardo, Rosamaria; Ruponen, Marika; Rautio, Jarkko; Ghelardini, Carla; Di Cesare Mannelli, Lorenzo; Calosi, Laura; Bani, Daniele; Lampinen, Riikka; Kanninen, Katja M.; Koivisto, Anne M; Penttilä, Elina; Löppönen, Heikki; Pignatello, Rosario. 2023. Pharmaceutics. 15: -
Sweet Battle of the Epimers─Continued Exploration of Monosaccharide-Derived Delivery Agents for Boron Neutron Capture Therapy
Matović, Jelena; Bahrami, Katayun; Stockmann, Philipp; Sokka, Iris K; Khng, You Cheng; Sarparanta, Mirkka; Hey-Hawkins, Evamarie; Rautio, Jarkko; Ekholm, Filip S. 2023. Molecular pharmaceutics. 20: 3127-3139 -
Development of Sesamol Carbamate-L-Phenylalanine Prodrug Targeting L-Type Amino Acid Transporter1 (LAT1) as a Potential Antiproliferative Agent against Melanoma
Srisongkram, Tarapong; Bahrami, Katayun; Järvinen, Juulia; Timonen, Juri; Rautio, Jarkko; Weerapreeyakul, Natthida. 2022. International journal of molecular sciences. 23: . 8446 -
In-vitro dynamic dissolution/bioconversion/permeation of fosamprenavir using a novel tool with an artificial biomimetic permeation barrier and microdialysis-sampling
Eriksen, Jonas Borregaard; Christiansen, Jeppe Juhl; Bauer-Brandl, Annette; Ruponen, Marika; Rautio, Jarkko; Brandl, Martin. 2022. European journal of pharmaceutical sciences. 2023; 181: -
Structural Features Affecting the Interactions and Transportability of LAT1-Targeted Phenylalanine Drug Conjugates
Bahrami, Katayun; Järvinen, Juulia; Laitinen, Tuomo; Reinisalo, Mika; Honkakoski, Paavo; Poso, Antti; Huttunen, Kristiina M.; Rautio, Jarkko. 2022. Molecular pharmaceutics. 2023; 20: 206-218 -
Synthesis and In Vitro Evaluation of a Set of 6-Deoxy-6-thio-carboranyl d-Glucoconjugates Shed Light on the Substrate Specificity of the GLUT1 Transporter
Matović, Jelena; Järvinen, Juulia; Sokka, Iris K; Stockmann, Philipp; Kellert, Martin; Imlimthan, Surachet; Sarparanta, Mirkka; Johansson, Mikael P; Hey-Hawkins, Evamarie; Rautio, Jarkko; Ekholm, Filip S. 2022. ACS omega. 7: 30376-30388 -
Molecular characteristics supporting L-Type amino acid transporter 1 (LAT1)-mediated translocation
Kärkkäinen, Jussi; Laitinen, Tuomo; Markowicz-Piasecka, Magdalena; Montaser, Ahmed; Lehtonen, Marko; Rautio, Jarkko; Gynther, Mikko; Poso, Antti; Huttunen, Kristiina M. 2021. Bioorganic chemistry. 112: 104921 -
Species differences in the intra-brain distribution of an L-type amino acid transporter 1 (LAT1) -utilizing compound between mice and rats
Jalkanen, Aaro J.; Ihalainen, Jouni; Lehtonen, Marko; Forsberg, Markus M.; Rautio, Jarkko; Huttunen, Kristiina M.; Gynther, Mikko. 2021. International journal of pharmaceutics. 596: 120300 -
Addressing the biochemical foundations of a glucose-based "Trojan horse"-stradegy to boron neutron capture therephy: from chemical synthesis to in vitro assesment
Matovic, Jelena; Järvinen, Juulia; Bland, Helena C; Sokka, Iris K; Imlimthan, Surachet; Ferrando, Ruth Mateu; Huttunen, Kristiina M; Timonen, Juri; Peräniemi, Sirpa; Aitio, Olli; Airaksinen, Anu J; Sarparanta, Mirkka; Johansson, Mikael P; Rautio, Jarkko; Ekholm, Filip S. 2020. Molecular pharmaceutics. 17: 3885-3899 -
Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-7
Gütschow, Michael; Eynde, Jean Jacques Vanden; Jampilek, Josef; Kang, CongBao; Mangoni, Arduino A; Fossa, Paola; Karaman, Rafik; Trabocchi, Andrea; Scott, Peter JH; Reynisson, Jóhannes; Rapposelli, Simona; Galdiero, Stefania; Winum, Jean-Yves; Brullo, Chiara; Prokai-Tatrai, Katalin; Sharma, Arun K; Schapira, Matthieu; Azuma, Yasu-Taka; Cerchia, Laura; Spetea, Mariana; et al. [incl. Rautio, J]. 2020. Molecules. 25: E2968