Jarkko Rautio
Deputy Head of Department
Professor
Vice-Head of Department Professor of Pharmaceutical Chemistry, vice-head of the School of Pharmacy and director of the Doctoral Programme in Drug Research (DPDR).
School of Pharmacy, Faculty of Health Sciences
jarkko.rautio@uef.fi | +358 40 353 2791
My research is focused on the chemistry-based methods, especially prodrugs, in drug delivery and targeting. Much of the research is currently focusing on exploiting the body’s natural mechanisms for transporting nutrients, the LAT1 and GLUT1 proteins, for targeted drug delivery across the blood-brain barrier (BBB) and cancer cells that express these transporters.
Research groups
Publications
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A technological comparison of freeze-dried poly-ɛ-caprolactone (PCL) and poly (lactic-co-glycolic acid) (PLGA) nanoparticles loaded with clozapine for nose-to-brain delivery
Lombardo, Rosamaria; Ruponen, Marika; Rautio, Jarkko; Lampinen, Riikka; Kanninen, Katja M.; Koivisto, Anne M.; Penttilä, Elina; Löppönen, Heikki; Demartis, Sara; Giunchedi, Paolo; Rassu, Giovanna; Fragalà, Maria Elena; Pignatello, Rosario. 2024. Journal of drug delivery science and technology. 93: . 105419 -
Formulating Resveratrol and Melatonin Self-Nanoemulsifying Drug Delivery Systems (SNEDDS) for Ocular Administration Using Design of Experiments
Zingale, Elide; Bonaccorso, Angela; D’Amico, Agata Grazia; Lombardo, Rosamaria; D’Agata, Velia; Rautio, Jarkko; Pignatello, Rosario. 2024. Pharmaceutics. 16: -
Prodrugs as empowering tools in drug discovery and development: recent strategic applications of drug delivery solutions to mitigate challenges associated with lead compounds and drug candidates
Subbaiah, Murugaiah A M; Rautio, Jarkko; Meanwell, Nicholas A. 2024. Chemical society reviews. 53: 2099-2210 -
Specific Transport of Temozolomide Does Not Override DNA Repair-mediated Chemoresistance
Bahrami, Katayan; Kärkkäinen, Jussi; Bibi, Sania; Huttunen, Johanna; Tampio, Janne; Montaser, Ahmed B.; Moody, Catherine L; Lehtonen, Marko; Rautio, Jarkko; Wheelhouse, Richard T; Huttunen, Kristiina M. 2024. European journal of pharmaceutical sciences. 195: -
Altering distribution profile of palbociclib by its prodrugs
Järvinen, Juulia; Montaser, Ahmed B; Adla, Santosh Kumar; Leppänen, Jukka; Lehtonen, Marko; Vellonen, Kati-Sisko; Laitinen, Tuomo; Jalkanen, Aaro; Elmquist, William F; Timonen, Juri; Huttunen, Kristiina M; Rautio, Jarkko. 2023. European journal of pharmaceutical sciences. 2024; 192: -
Amino Acid-Based Boron Carriers in Boron Neutron Capture Therapy (BNCT)
Järvinen, Juulia; Pulkkinen, Herkko; Rautio, Jarkko; Timonen, Juri M. 2023. Pharmaceutics. 15: -
Development of Lyophilised Eudragit® Retard Nanoparticles for the Sustained Release of Clozapine via Intranasal Administration
Lombardo, Rosamaria; Ruponen, Marika; Rautio, Jarkko; Ghelardini, Carla; Di Cesare Mannelli, Lorenzo; Calosi, Laura; Bani, Daniele; Lampinen, Riikka; Kanninen, Katja M.; Koivisto, Anne M; Penttilä, Elina; Löppönen, Heikki; Pignatello, Rosario. 2023. Pharmaceutics. 15: -
Farmaseuttinen kemia
Jarho, Pekka; Lahtela-Kakkonen, Maija; Vepsäläinen, Jouko; Rautio, Jarkko; Huttunen, Kristiina; Poso, Antti; Auriola, Seppo. 2023. Publications of the University of Eastern Finland. General series. 44: 32-35 -
Sweet Battle of the Epimers─Continued Exploration of Monosaccharide-Derived Delivery Agents for Boron Neutron Capture Therapy
Matović, Jelena; Bahrami, Katayun; Stockmann, Philipp; Sokka, Iris K; Khng, You Cheng; Sarparanta, Mirkka; Hey-Hawkins, Evamarie; Rautio, Jarkko; Ekholm, Filip S. 2023. Molecular pharmaceutics. 20: 3127-3139 -
Targeting Glial Cells by Organic Anion-Transporting Polypeptide 1C1 (OATP1C1)-Utilizing l-Thyroxine-Derived Prodrugs
Tonduru, Arun Kumar; Maljaei, Seyed Hamed; Adla, Santosh Kumar; Anamea, Landry; Tampio, Janne; Králová, Adéla; Jalkanen, Aaro J; Espada, Catarina; Santos, Inês Falcato; Montaser, Ahmed B; Rautio, Jarkko; Kronenberger, Thales; Poso, Antti; Huttunen, Kristiina M. 2023. Journal of medicinal chemistry. 66: 15094-15114