Marko Lehtonen
Research Director
School of Pharmacy, Faculty of Health Sciences
marko.lehtonen@uef.fi | +358 40 355 2250
Research groups
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Analytical unit of the school of Pharmacy 27.02.2020 - -
LC-MS metabolomics center 01.09.2023 - -
Microplastic research 01.09.2016 -
Projects
Publications
137/137 items-
Anthraquinone biocolourant dermocybin is metabolized whereas dermorubin is not in in vitro liver fractions and recombinant metabolic enzymes
Yli-Öyrä, Johanna; Juvonen, Risto O; Lehtonen, Marko; Herrala, Mikko; Finel, Moshe; Räisänen, Riikka; Rysä, Jaana. 2024. Basic and clinical pharmacology and toxicology. [Epub ahead of print 25 April 2024]: 1-12 A1 Journal article (refereed), original research -
Dietary Caffeine and Brain Dopaminergic Function in Parkinson Disease
Saarinen, Emmi K; Kuusimäki, Tomi; Lindholm, Kari; Niemi, Kalle; Honkanen, Emma A; Noponen, Tommi; Seppänen, Marko; Ihalainen, Toni; Murtomäki, Kirsi; Mertsalmi, Tuomas; Jaakkola, Elina; Myller, Elina; Eklund, Mikael; Nuuttila, Simo; Levo, Reeta; Chaudhuri, Kallol Ray; Antonini, Angelo; Vahlberg, Tero; Lehtonen, Marko; Joutsa, Juho; Scheperjans, Filip; Kaasinen, Valtteri. 2024. Annals of neurology. 96: 262-275 A1 Journal article (refereed), original research -
Eight-year Diet and Physical Activity Intervention Affects Serum Metabolites during Childhood & Adolescence: A Nonrandomized Controlled Trial
Zarei, Iman; Eloranta, Aino-Maija; Klåvus, Anton; Väistö, Juuso; Lehtonen, Marko; Mikkonen, Santtu; Koistinen, Ville M; Sallinen, Taisa; Haapala, Eero A; Lintu, Niina; Soininen, Sonja; Haikonen, Retu; Atalay, Mustafa; Schwab, Ursula; Auriola, Seppo; Kolehmainen, Marjukka; Hanhineva, Kati; Lakka, Timo A. 2024. iScience. 27: A1 Journal article (refereed), original research -
Fasting plasma metabolites reflecting meat consumption and their associations with incident type 2 diabetes in two Swedish cohorts
Noerman, Stefania; Johansson, Anna; Shi, Lin; Lehtonen, Marko; Hanhineva, Kati; Johansson, Ingegerd; Brunius, Carl; Landberg, Rikard. 2024. American journal of clinical nutrition. 119: 1280-1292 A1 Journal article (refereed), original research -
Metabolic changes in response to varying whole-grain wheat and rye intake
Koistinen, Ville M; Haldar, Sumanto; Tuomainen, Marjo; Lehtonen, Marko; Klåvus, Anton; Draper, John; Lloyd, Amanda; Beckmann, Manfred; Bal, Wendy; Ross, Alastair B; Brandt, Kirsten; Fawcett, Lee; Seal, Chris; Hanhineva, Kati. 2024. npj science of food. 8: . 8 A1 Journal article (refereed), original research -
Non‐targeted metabolomics for the identification of plasma metabolites associated with organic anion transporting polypeptide 1B1 function
Hämäläinen, Kreetta; Hirvensalo, Päivi; Neuvonen, Mikko; Tornio, Aleksi; Backman, Janne T; Lehtonen, Marko; Niemi, Mikko. 2024. Cts: clinical and translational science. 17: 1-14 A1 Journal article (refereed), original research -
Solanidine is a sensitive and specific dietary biomarker for CYP2D6 activity
Kiiski, Johanna I; Neuvonen, Mikko; Kurkela, Mika; Hirvensalo, Päivi; Hämäläinen, Kreetta; Tarkiainen, E Katriina; Sistonen, Johanna; Korhonen, Mari; Khan, Sofia; Orpana, Arto; Filppula, Anne M; Lehtonen, Marko; Niemi, Mikko. 2024. Human genomics. 18: . 11 A1 Journal article (refereed), original research -
Specific Transport of Temozolomide Does Not Override DNA Repair-mediated Chemoresistance
Bahrami, Katayan; Kärkkäinen, Jussi; Bibi, Sania; Huttunen, Johanna; Tampio, Janne; Montaser, Ahmed B.; Moody, Catherine L; Lehtonen, Marko; Rautio, Jarkko; Wheelhouse, Richard T; Huttunen, Kristiina M. 2024. European journal of pharmaceutical sciences. 195: A1 Journal article (refereed), original research -
The L-type amino acid transporter 1 enhances drug delivery to the mouse pancreatic beta cell line (MIN6)
Tampio, Janne; Montaser, Ahmed B.; Järvinen, Juulia; Lehtonen, Marko; Jalkanen, Aaro J.; Reinisalo, Mika; Kokkola, Tarja; Terasaki, Tetsuya; Laakso, Markku; Rysä, Jaana; Kauppinen, Anu; Huttunen, Kristiina M. 2024. European journal of pharmaceutical sciences. 203: A1 Journal article (refereed), original research -
The metabolic response of HepG2 cells to extracellular vesicles derived from Raphanus sativus L. var. caudatus Alef microgreens probed by chemometrics-assisted LC-MS/MS analysis
Kaimuangpak, Karnchanok; Srisongkram, Tarapong; Lehtonen, Marko; Rautio, Jarkko; Weerapreeyakul, Natthida. 2024. Food chemistry. 461: A1 Journal article (refereed), original research -
Aerobic exercise training and gut microbiome-associated metabolic shifts in women with overweight: a multi-omic study
Hintikka, Jukka E; Ahtiainen, Juha P; Permi, Perttu; Jalkanen, Sirpa; Lehtonen, Marko; Pekkala, Satu. 2023. Scientific reports. 13: A1 Journal article (refereed), original research -
Altering distribution profile of palbociclib by its prodrugs
Järvinen, Juulia; Montaser, Ahmed B; Adla, Santosh Kumar; Leppänen, Jukka; Lehtonen, Marko; Vellonen, Kati-Sisko; Laitinen, Tuomo; Jalkanen, Aaro; Elmquist, William F; Timonen, Juri; Huttunen, Kristiina M; Rautio, Jarkko. 2023. European journal of pharmaceutical sciences. 2024; 192: A1 Journal article (refereed), original research -
Buprenorphine plasma and cerebrospinal fluid concentrations in osteoarthritis patients during low-dose transdermal patch dosing
Härkänen, Lasse; Hakomäki, Henriikka; Huopio, Jukka; Kokki, Hannu; Korhonen, Sanni; Lehtonen, Marko; Sjövall, Sari; Kokki, Merja. 2023. European journal of clinical pharmacology. 79: 1709-1711 A1 Journal article (refereed), original research -
Cold-stimulated brown adipose tissue activation is related to changes in serum metabolites relevant to NAD+ metabolism in humans
U-Din, Mueez; de Mello, Vanessa D; Tuomainen, Marjo; Raiko, Juho; Niemi, Tarja; Fromme, Tobias; Klåvus, Anton; Gautier, Nadine; Haimilahti, Kimmo; Lehtonen, Marko; Kristiansen, Karsten; Newman, John W; Pietiläinen, Kirsi H; Pihlajamäki, Jussi; Amri, Ez-Zoubir; Klingenspor, Martin; Nuutila, Pirjo; Pirinen, Eija; Hanhineva, Kati; Virtanen, Kirsi A. 2023. Cell reports. 42: A1 Journal article (refereed), original research -
Comparative steroid profiling of newborn hair and umbilical cord serum highlights the role of fetal adrenals, placenta, and pregnancy outcomes in fetal steroid metabolism
Koskivuori, Johanna; Voutilainen, Raimo; Storvik, Markus; Hakkinen, Merja R.; Uusitalo, Lauri; Keski-Nisula, Leea; Backman, Katri; Auriola, Seppo; Lehtonen, Marko. 2023. Journal of steroid biochemistry and molecular biology. 232: A1 Journal article (refereed), original research -
Identification of Gut Microbial Lysine and Histidine Degradation and CYP-Dependent Metabolites as Biomarkers of Fatty Liver Disease
Driuchina, Anastasiia; Hintikka, Jukka; Lehtonen, Marko; Keski-Rahkonen, Pekka; O’Connell, Thomas; Juvonen, Risto; Kuula, Juho; Hakkarainen, Antti; Laukkanen, Jari A; Mäkinen, Elina; Lensu, Sanna; Pietiläinen, Kirsi H; Pekkala, Satu. 2023. Mbio. 14: . e02663-22 A1 Journal article (refereed), original research -
Metabolic profiles reflect weight loss maintenance and the composition of diet after very-low-energy diet
Näätänen, Mari; Kårlund, Anna; Mikkonen, Santtu; Klåvus, Anton; Savolainen, Otto; Lehtonen, Marko; Karhunen, Leila; Hanhineva, Kati; Kolehmainen, Marjukka. 2023. Clinical nutrition. 42: 1126-1141 A1 Journal article (refereed), original research -
Nicotinamide riboside improves muscle mitochondrial biogenesis, satellite cell differentiation, and gut microbiota in a twin study
Lapatto, Helena A. K.; Kuusela, Minna; Heikkinen, Aino; Muniandy, Maheswary; van der Kolk, Birgitta W.; Gopalakrishnan, Swetha; Pöllänen, Noora; Sandvik, Martin; Schmidt, Mark S.; Heinonen, Sini; Saari, Sina; Kuula, Juho; Hakkarainen, Antti; Tampio, Janne; Saarinen, Tuure; Taskinen, Marja-Riitta; Lundbom, Nina; Groop, Per-Henrik; Tiirola, Marja; Katajisto, Pekka; Lehtonen, Marko; Brenner, Charles; Kaprio, Jaakko; Pekkala, Satu; Ollikainen, Miina; Pietiläinen, Kirsi H.; Pirinen, Eija. 2023. Science advances. 9: 1-23 A1 Journal article (refereed), original research -
Physicochemical stability of high-concentration cefuroxime aqueous injection reconstituted by a centralised intravenous additive service
Vilanti, Anna; Helin-Tanninen, Minna; Isotalo, Antti; Mustonen, Juho; Koskivuori, Johanna; Korhonen, Ossi; Lehtonen, Marko. 2023. European journal of hospital pharmacy: science and practice. [Published Online First: 27 August 2023]: A1 Journal article (refereed), original research -
Potent dual MAGL/FAAH inhibitor AKU-005 engages endocannabinoids to diminish meningeal nociception implicated in migraine pain
Della Pietra, Adriana; Krivoshein, Georgii; Ivanov, Konstantin; Giniatullina, Raisa; Jyrkkänen, Henna-Kaisa; Leinonen, Ville; Lehtonen, Marko; van den Maagdenberg, Arn MJM; Savinainen, Juha; Giniatullin, Rashid. 2023. Journal of headache and pain. 24: . 38 A1 Journal article (refereed), original research -
Pregnane X receptor activation remodels glucose metabolism to promote NAFLD development in obese mice
Karpale, Mikko; Kummu, Outi; Kärkkäinen, Olli; Lehtonen, Marko; Näpänkangas, Juha; Herfurth, Uta M; Braeuning, Albert; Rysä, Jaana; Hakkola, Jukka. 2023. Molecular metabolism. 76: A1 Journal article (refereed), original research -
A quantitative ultra-performance liquid chromatography high-resolution mass spectrometry analysis of steroids from human scalp hair
Koskivuori, Johanna; Voutilainen, Raimo; Uusitalo, Lauri; Lehtonen, Marko; Lakka, Timo; Auriola, Seppo; Häkkinen, Merja R. 2022. Journal of pharmaceutical and biomedical analysis. 215: A1 Journal article (refereed), original research -
Altered activities of CYP1A1 and CYP19A1 enzymes in women using SSRI medication during pregnancy
Sahlman, H; Itkonen, A; Lehtonen, M; Keski-Nisula, L; Rysä, J. 2022. Placenta. 129: 30-35 A1 Journal article (refereed), original research -
Central Nervous System Distribution of Buprenorphine in Pregnant Sheep, Fetuses and Newborn Lambs After Continuous Transdermal and Single Subcutaneous Extended-Release Dosing
Hakomäki, Henriikka; Eskola, Sophia; Kokki, Hannu; Lehtonen, Marko; Räsänen, Juha; Laaksonen, Sakari; Voipio, Hanna-Marja; Ranta, Veli-Pekka; Kokki, Merja. 2022. European journal of pharmaceutical sciences. 178: A1 Journal article (refereed), original research -
Enhanced drug delivery by a prodrug approach effectively relieves neuroinflammation in mice
Montaser, Ahmed B.; Kuiri, Janita; Natunen, Teemu; Hruška, Pavel; Potěšil, David; Auriola, Seppo; Hiltunen, Mikko; Terasaki, Tetsuya; Lehtonen, Marko; Jalkanen, Aaro; Huttunen, Kristiina M. 2022. Life sciences. 310: A1 Journal article (refereed), original research -
Metabolite Pattern Derived from Lactiplantibacillus plantarum — Fermented Rye Foods and In Vitro Gut Fermentation Synergistically Inhibits Bacterial Growth
Koistinen, Ville M.; Hedberg, Maria; Shi, Lin; Johansson, Anders; Savolainen, Otto; Lehtonen, Marko; Aura, Anna‐Marja; Hanhineva, Kati; Landberg, Rikard. 2022. Molecular nutrition and food research. 66: A1 Journal article (refereed), original research -
Metabolomics of Synovial Fluid and Infrapatellar Fat Pad in Patients with Osteoarthritis or Rheumatoid Arthritis
Nieminen, Petteri; Hämäläinen, Wilhelmiina; Savinainen, Juha; Lehtonen, Marko; Lehtiniemi, Saara; Rinta-Paavola, Juho; Lehenkari, Petri; Kääriäinen, Tommi; Joukainen, Antti; Kröger, Heikki; Paakkonen, Tommi; Mustonen, Anne-Mari. 2022. Inflammation. 45: 1101-1117 A1 Journal article (refereed), original research -
Serum Creatine, Not Neurofilament Light, Is Elevated in CHCHD10-Linked Spinal Muscular Atrophy
Järvilehto, Julius; Harjuhaahto, Sandra; Palu, Edouard; Auranen, Mari; Kvist, Jouni; Zetterberg, Henrik; Koskivuori, Johanna; Lehtonen, Marko; Saukkonen, Anna Maija; Jokela, Manu; Ylikallio, Emil; Tyynismaa, Henna. 2022. Frontiers in neurology. 13: . 793937 A1 Journal article (refereed), original research -
Serum metabolites associated with wholegrain consumption using nontargeted metabolic profiling: a discovery and reproducibility study
Noerman, Stefania; Virtanen, Jyrki K.; Lehtonen, Marko; Brunius, Carl; Hanhineva, Kati. 2022. European journal of nutrition. 2023; 62: 713-726 A1 Journal article (refereed), original research -
Tissue-wide metabolomics reveals wide impact of gut microbiota on mice metabolite composition
Zarei, Iman; Koistinen, Ville M.; Kokla, Marietta; Klåvus, Anton; Babu, Ambrin Farizah; Lehtonen, Marko; Auriola, Seppo; Hanhineva, Kati. 2022. Scientific reports. 12: . 15018 A1 Journal article (refereed), original research -
A non-targeted LC-MS metabolic profiling of pregnancy: longitudinal evidence from healthy and pre-eclamptic pregnancies
Jääskeläinen, Tiina; Kärkkäinen, Olli; Jokkala, Jenna; Klåvus, Anton; Heinonen, Seppo; Auriola, Seppo; Lehtonen, Marko; The FINNPEC Core Investigator Group; Hanhineva, Kati; Laivuori, Hannele. 2021. Metabolomics. 17: 20 A1 Journal article (refereed), original research -
Associations of the serum metabolite profile with a healthy Nordic diet and risk of coronary artery disease
Noerman, Stefania; Kokla, Marietta; Koistinen, Ville M; Lehtonen, Marko; Tuomainen, Tomi-Pekka; Brunius, Carl; Virtanen, Jyrki K; Hanhineva, Kati. 2021. Clinical nutrition. 40: 3250-3262 A1 Journal article (refereed), original research -
Changes in the metabolic profile of human male postmortem frontal cortex and cerebrospinal fluid samples associated with heavy alcohol use
Kärkkäinen, Olli; Kokla, Marietta; Lehtonen, Marko; Auriola, Seppo; Martiskainen, Mika; Tiihonen, Jari; Karhunen, Pekka J.; Hanhineva, Kati; Kok, Eloise. 2021. Addiction biology. 26: e13035 A1 Journal article (refereed), original research -
Effect of intravenous ghrelin administration, combined with alcohol, on circulating metabolome in heavy drinking individuals with alcohol use disorder
Kärkkäinen, Olli; Farokhnia, Mehdi; Klåvus, Anton; Auriola, Seppo; Lehtonen, Marko; Deschaine, Sara L.; Piacentino, Daria; Abshire, Kelly M.; Jackson, Shelley N.; Leggio, Lorenzo. 2021. Alcoholism-clinical and experimental research. 45: 2207-2216 A1 Journal article (refereed), original research -
Ganciclovir and Its Hemocompatible More Lipophilic Derivative Can Enhance the Apoptotic Effects of Methotrexate by Inhibiting Breast Cancer Resistance Protein (BCRP)
Markowicz-Piasecka, M; Huttunen, J; Montaser, A; Adla, SK; Auriola, S; Lehtonen, M; Huttunen, KM. 2021. International journal of molecular sciences. 22: 7727 A1 Journal article (refereed), original research -
Low-Dose Doxycycline Treatment Normalizes Levels of Some Salivary Metabolites Associated with Oral Microbiota in Patients with Primary Sjögren's Syndrome
Herrala, Maria; Turunen, Soile; Hanhineva, Kati; Lehtonen, Marko; Mikkonen, Jopi J. W.; Seitsalo, Hubertus; Lappalainen, Reijo; Tjäderhane, Leo; Niemelä, Raija K.; Salo, Tuula; Myllymaa, Sami; Kullaa, Arja M.; Kärkkäinen, Olli. 2021. Metabolites. 11: 595 A1 Journal article (refereed), original research -
Maternal and fetal buprenorphine pharmacokinetics in pregnant sheep during transdermal patch dosing: Buprenorphine pharmacokinetics in pregnant sheep
Hakomäki, Henriikka; Kokki, Hannu; Lehtonen, Marko; Räsänen, Juha; Voipio, Hanna-Marja; Ranta, Veli-Pekka; Kokki, Merja. 2021. European journal of pharmaceutical sciences. 165: 105936 A1 Journal article (refereed), original research -
Molecular characteristics supporting L-Type amino acid transporter 1 (LAT1)-mediated translocation
Kärkkäinen, Jussi; Laitinen, Tuomo; Markowicz-Piasecka, Magdalena; Montaser, Ahmed; Lehtonen, Marko; Rautio, Jarkko; Gynther, Mikko; Poso, Antti; Huttunen, Kristiina M. 2021. Bioorganic chemistry. 112: 104921 A1 Journal article (refereed), original research -
Pharmacokinetics of buprenorphine in pregnant sheep after intravenous injection
Hakomäki, Henriikka; Kokki; Hannu; Lehtonen, Marko; Ranta, Veli-Pekka; Räsänen, Juha; Voipio, Hanna-Marja; Kokki, Merja. 2021. Pharmacology research & perspectives. 9: e00726 A1 Journal article (refereed), original research -
Species differences in the intra-brain distribution of an L-type amino acid transporter 1 (LAT1) -utilizing compound between mice and rats
Jalkanen, Aaro J.; Ihalainen, Jouni; Lehtonen, Marko; Forsberg, Markus M.; Rautio, Jarkko; Huttunen, Kristiina M.; Gynther, Mikko. 2021. International journal of pharmaceutics. 596: 120300 A1 Journal article (refereed), original research -
Caffeine content in newborn hair correlates with maternal dietary intake
Lehtonen, Anni; Uusitalo, Lauri; Auriola, Seppo; Backman, Katri; Heinonen, Seppo; Keski-Nisula, Leea; Pasanen, Markku; Pekkanen, Juha; Tuomainen, Tomi-Pekka; Voutilainen, Raimo; Hantunen, Sari; Lehtonen, Marko. 2020. European journal of nutrition. 2021; 60: 193-201 A1 Journal article (refereed), original research -
Changes in circulating metabolome precede alcohol-related diseases in middle-aged men: a prospective population-based study with a 30-year follow-up
Kärkkäinen, Olli; Klåvus, Anton; Voutilainen, Ari; Virtanen, Jyrki; Lehtonen, Marko; Auriola, Seppo; Kauhanen, Jussi; Rysä, Jaana. 2020. Alcoholism-clinical and experimental research. 44: 2457-2467 A1 Journal article (refereed), original research -
Inhibition of Human CYP1 Enzymes by a Classical Inhibitor α-Naphthoflavone and a Novel Inhibitor N-(3, 5- Dichlorophenyl)cyclopropanecarboxamide - An in Vitro and in Silico Study
Juvonen, RO; Jokinen, EM; Javaid, A; Lehtonen, M; Raunio, H; Pentikäinen, OT. 2020. Chemical biology and drug design. 95: 520-533 A1 Journal article (refereed), original research -
L-Type Amino Acid Transporter 1 Enables the Efficient Brain Delivery of Small-Sized Prodrug across the Blood-Brain Barrier and into Human and Mouse Brain Parenchymal Cells
Montaser, Ahmed B; Järvinen, Juulia; Löffler, Susanne; Huttunen, Johanna; Auriola, Seppo; Lehtonen, Marko; Jalkanen, Aaro; Huttunen, Kristiina M. 2020. Acs chemical neuroscience. 11: 4301-4315 A1 Journal article (refereed), original research -
L-Type Amino Acid Transporter 1-Utilizing Prodrugs of Ketoprofen Can Efficiently Reduce Brain Prostaglandin Levels
Montaser, Ahmed; Lehtonen, Marko; Gynther, Mikko; Huttunen, Kristiina. 2020. Pharmaceutics. 12: 344 A1 Journal article (refereed), original research -
Metabolic alterations in Parkinson's disease astrocytes
Sonninen, Tuuli-Maria; Hämäläinen, Riikka H; Koskuvi, Marja; Oksanen, Minna; Shakirzyanova, Anastasia; Wojciechowski, Sara; Puttonen, Katja; Naumenko, Nikolay; Goldsteins, Gundars; Laham-Karam, Nihay; Lehtonen, Marko; Tavi, Pasi; Koistinaho, Jari; Lehtonen, ¦árka. 2020. Scientific reports. 10: 14474 A1 Journal article (refereed), original research -
Tissue and interspecies comparison of catechol- O-methyltransferase mediated catalysis of 6- O-methylation of esculetin to scopoletin and its inhibition by entacapone and tolcapone
Jalkanen, Aaro; Lassheikki, Veera; Torsti, Tommi; Gharib, Elham; Lehtonen, Marko; Juvonen, Risto O. 2020. Xenobiotica. 2021; 51: 268-278 A1 Journal article (refereed), original research -
Gender and dose-related metabolome alterations in rat offspring after in utero and lactational exposure to PCB 180
Pikkarainen, A; Lehtonen, M; Håkansson, H; Auriola, S; Viluksela, M. 2019. Toxicology and applied pharmacology. 370: 56-64 A1 Journal article (refereed), original research -
In Vitro Human Metabolism and Inhibition Potency of Verbascoside for CYP Enzymes
Reid, AM; Juvonen, R; Huuskonen, P; Lehtonen, M; Pasanen, M; Lall, N. 2019. Molecules. 24: 2191 A1 Journal article (refereed), original research -
Quantitative assessment of betainized compounds and associations with dietary and metabolic biomarkers in the randomized study of the healthy Nordic diet (SYSDIET)
Tuomainen, M; Kärkkäinen, O; Leppänen, J; Auriola, S; Lehtonen, M; Savolainen, MJ; Hermansen, K; Risérus, U; Åkesson, B; Thorsdottir, I; Kolehmainen, M; Uusitupa, M; Poutanen, K; Schwab, U; Hanhineva, K. 2019. American journal of clinical nutrition. 110: 1108-1118 A1 Journal article (refereed), original research -
A Non-Targeted LC-MS Profiling Reveals Elevated Levels of Carnitine Precursors and Trimethylated Compounds in the Cord Plasma of Pre-Eclamptic Infants
Jääskeläinen, Tiina; Kärkkäinen, Olli; Jokkala, Jenna; Litonius, Kaisa; Heinonen, Seppo; Auriola, Seppo; Lehtonen, Marko; Hanhineva, Kati; Laivuori, Hannele; FINNPEC. 2018. Scientific reports. 8: 14616 A1 Journal article (refereed), original research -
A prospective, randomized, open label, controlled study investigating the efficiency and safety of 3 different methods of rectus sheath block analgesia following midline laparotomy
Purdy, Martin; Kinnunen, Mari; Kokki, Merja; Anttila, Maarit; Eskelinen, Matti; Hautajärvi, Heidi; Lehtonen, Marko; Kokki, Hannu. 2018. Medicine. 97: e9968 A1 Journal article (refereed), original research -
Alcohol and substance use are associated with altered metabolome in the first trimester serum samples of pregnant mothers
Lehikoinen, Anni I; Kärkkäinen, Olli K; Lehtonen, Marko AS; Auriola, Seppo OK; Hanhineva, Kati J; Heinonen, Seppo T. 2018. European journal of obstetrics and gynecology and reproductive biology. 223: 79-84 A1 Journal article (refereed), original research -
Associations of serum indolepropionic acid, a gut microbiota metabolite, with type 2 diabetes and low-grade inflammation in high-risk individuals
Tuomainen, Marjo; Lindström, Jaana; Lehtonen, Marko; Auriola, Seppo; Pihlajamäki, Jussi; Peltonen, Markku; Tuomilehto, Jaakko; Uusitupa, Matti; de Mello, Vanessa D; Hanhineva, Kati. 2018. Nutrition and diabetes. 8: 35 A1 Journal article (refereed), original research -
Diets rich in whole grains increase betainized compounds associated with glucose metabolism
Kärkkäinen, O; Lankinen, MA; Vitale, M; Jokkala, J; Leppänen, J; Koistinen, V; Lehtonen, M; Giacco, R; Rosa-Sibakov, N; Micard, V; Rivellese, AAA; Schwab, U; Mykkänen, H; Uusitupa, M; Kolehmainen, M; Riccardi, G; Poutanen, K; Auriola, S; Hanhineva, K. 2018. American journal of clinical nutrition. 108: 971-979 A1 Journal article (refereed), original research -
Fearful dogs have increased plasma glutamine and gamma-glutamyl glutamine
Puurunen, Jenni; Tiira, Katriina; Vapalahti, Katarooma; Lehtonen, Marko; Hanhineva, Kati; Lohi, Hannes. 2018. Scientific reports. 8: 15976 A1 Journal article (refereed), original research -
Heart specific PGC-1[alfa] deletion identifies metabolome of cardiac restricted metabolic heart failure
Kärkkäinen, Olli; Tuomainen, Tomi; Mutikainen, Maija; Lehtonen, Marko; Ruas, Jorge L; Hanhineva, Kati; Tavi, Pasi. 2018. Cardiovascular research. 2019; 115: 107-118 A1 Journal article (refereed), original research -
Metabolic Profiling of High Egg Consumption and the Associated Lower Risk of Type 2 Diabetes in Middle-Aged Finnish Men
Noerman, S; Kärkkäinen, O; Mattsson, A; Paananen, J; Lehtonen, M; Nurmi, T; Tuomainen, TP; Voutilainen, S; Hanhineva, K; Virtanen, JK. 2018. Molecular nutrition and food research. 2019; 63: 1800605 A1 Journal article (refereed), original research -
Plasma metabolites associated with type 2 diabetes in a Swedish population: a case-control study nested in a prospective cohort
Shi, L; Brunius, C; Lehtonen, M; Auriola, S; Bergdahl, IA; Rolandsson, O; Hanhineva, K; Landberg, R. 2018. Diabetologia. 61: 849-861 A1 Journal article (refereed), original research -
Whole grain intake associated molecule 5-aminovaleric acid betaine decreases ß-oxidation of fatty acids in mouse cardiomyocytes
Kärkkäinen, Olli; Tuomainen, Tomi; Koistinen, Ville; Tuomainen, Marjo; Leppänen, Jukka; Laitinen, Tuomo; Lehtonen, Marko; Rysä, Jaana; Auriola, Seppo; Poso, Antti; Tavi, Pasi; Hanhineva, Kati. 2018. Scientific reports. 8: 13036 A1 Journal article (refereed), original research -
Absorption of ibuprofen orodispersible tablets in early postoperative phase : a pharmacokinetic study
Piirainen A, Kokki M, Lidsle HM, Lehtonen M, Ranta VP, Kokki H. 2017. Current medical research and opinion. 2018; 34: 683-688 A1 Journal article (refereed), original research -
Combined ipsilateral limb use score as an index of motor deficits and neurorestoration in parkinsonian rats
Leikas JV, Kääriäinen TM, Jalkanen AJ, Lehtonen M, Rantamäki T, Forsberg MM. 2017. Journal of neuroscience research. 95: 1858-1870 A1 Journal article (refereed), original research -
Dose-response effect of acute phencyclidine on functional connectivity and dopamine levels, and their association with schizophrenia-like symptom classes in rat
Paasonen J, Salo RA, Ihalainen J, Leikas JV, Savolainen K, Lehtonen M, Forsberg MM, Gröhn O. 2017. Neuropharmacology. 119: 15-25 A1 Journal article (refereed), original research -
Fasting serum hippuric acid is elevated after bilberry (Vaccinium myrtillus) consumption and associates with improvement of fasting glucose levels and insulin secretion in persons at high risk of developing type 2 diabetes
de Mello VD, Lankinen MA, Lindström J, Puupponen-Pimiä R, Laaksonen DE, Pihlajamäki J, Lehtonen M, Uusitupa M, Tuomilehto J, Kolehmainen M, Törrönen R, Hanhineva K. 2017. Molecular nutrition and food research. 61: 1700019 A1 Journal article (refereed), original research -
High-accuracy mass spectrometry for identification of sulphur-containing bioactive constituents and flavonoids in extracts of Raphanus sativus var. caudatus Alef (Thai rat-tailed radish)
Sangthonga S, Weerapreeyakulb N, Lehtonen M, Leppanen J, Rautio J. 2017. Journal of functional foods. 31: 237-247 A1 Journal article (refereed), original research -
Indolepropionic acid and novel lipid metabolites are associated with a lower risk of type 2 diabetes in the Finnish Diabetes Prevention Study
de Mello VD, Paananen J, Lindstrom J, Lankinen MA, Shi L, Kuusisto J, Pihlajamaki J, Auriola S, Lehtonen M, Rolandsson O, Bergdahl IA, Nordin E, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Landberg R, Eriksson JG, Tuomilehto J, Hanhineva K, Uusitupa M. 2017. Scientific reports. 7: 46337 A1 Journal article (refereed), original research -
A non-targeted metabolite profiling pilot study suggests that tryptophan and lipid metabolisms are linked with ADHD-like behaviours in dogs
Puurunen Jenni, Sulkama Sini, Tiira Katriina, Araujo Cesar, Lehtonen Marko, Hanhineva Kati, Lohi Hannes. 2016. Behavioral and brain functions. 12: 27 A1 Journal article (refereed), original research -
Amino Acid Promoieties Alter Valproic Acid Pharmacokinetics and Enable Extended Brain Exposure
Gynther Mikko, Peura Lauri, Vernerová Monika, Leppänen Jukka, Kärkkäinen Jussi, Lehtonen Marko, Rautio Jarkko, Huttunen Kristiina M. 2016. Neurochemical research. 41: 2797-2809 A1 Journal article (refereed), original research -
Free fatty acid receptor 1 (GPR40) agonists containing spirocyclic periphery inspired by LY2881835
Krasavin Mikhail, Lukin Alexey, Bagnyukova Daria, Zhurilo Nikolay, Zahanich Ihor, Zozulya Sergey, Ihalainen Jouni, Forsberg Markus M, Lehtonen Marko, Rautio Jarkko, Moore Daniel, Tikhonova Irina G. 2016. Bioorganic and medicinal chemistry. 24: 5481-5494 A1 Journal article (refereed), original research -
In vivo characterization of the ultrapotent monoacylglycerol lipase inhibitor {4-[bis-(benzo[d][1,3]dioxol-5-yl)methyl]-piperidin-1-yl} (1H-1,2,4-triazol-1-yl)methanone (JJKK-048)
Aaltonen Niina, Kedzierska Ewa, Orzelska-Gorka Jolanta, Lehtonen Marko, Navia-Paldanius Dina, Jakupovic Hermina, Savinainen Juha, Nevalainen Tapio, Laitinen Jarmo T, Parkkari Teija, Gynther Mikko. 2016. Journal of pharmacology and experimental therapeutics. 359: 62-72 A1 Journal article (refereed), original research -
Metabolic profiling discriminates between strawberry (Fragaria×ananassa Duch.) cultivars grown in Finland or Estonia
Kårlund Anna, Moor Ulvi, McDougall Gordon, Lehtonen Marko, Karjalainen Reijo O, Hanhineva Kati. 2016. Food research international. 89: 647-653 A1 Journal article (refereed), original research -
Non-targeted metabolite profiling highlights the potential of strawberry leaves as a resource for specific bioactive compounds
Kårlund Anna, Hanhineva Kati, Lehtonen Marko, McDougall Gordon J, Stewart Derek, Karjalainen Reijo O. 2016. Journal of the science of food and agriculture. 2017; 97: 2182-2190 A1 Journal article (refereed), original research -
Non-targeted metabolite profiling reveals changes in oxidative stress, tryptophan and lipid metabolisms in fearful dogs
Puurunen Jenni, Tiira Katriina, Lehtonen Marko, Hanhineva Kati, Lohi Hannes. 2016. Behavioral and brain functions. 12: 7 A1 Journal article (refereed), original research -
Nontargeted Metabolite Profiling of Induced Pluripotent Stem Cells (iPSCs) Derived Neural Cells: Insights Into Mechanisms of Brain Diseases
Lehtonen ¦árka, Lehtonen Marko, Koistinaho Jari. Teoksessa: Tomizava Minoru(toim.) , 2016. Pluripotent Stem Cells - From the Bench to the Clinic. s. 209-226. InTech Open A3 Book section, Chapters in research books -
Reduction in cardiometabolic risk factors by a multifunctional diet is mediated via several branches of metabolism as evidenced by non-targeted metabolite profiling approach
Tovar Juscelino, de Mello Vanessa D, Nilsson Anne, Johansson Maria, Paananen Jussi, Lehtonen Marko, Hanhineva Kati, Björck Inger. 2016. Molecular nutrition and food research. [Epub ahead of print 8 Nov 2016]: 1-12 A1 Journal article (refereed), original research -
The cerebrospinal fluid distribution of postoperatively administred dexketoprofen and etoricoxib and their effect on pain and inflammatory markers in patients undergoing hip arthroplasty
Piirainen Annika, Kokki Merja, Hautajärvi Heidi, Lehtonen Marko, Miettinen Hannu, Pulkki Kari, Ranta Veli-Pekka, Kokki Hannu. 2016. Clinical drug investigation. 36: 545-555 A1 Journal article (refereed), original research -
Amino acid-derived betaines dominate as urinary markers for rye bran intake in mice fed high-fat diet - a non-targeted metabolomics study
Pekkinen Jenna, Rosa-Sibakov Natalia, Micard Valerie, Keski-Rahkonen Pekka, Lehtonen Marko, Poutanen Kaisa, Mykkänen Hannu, Hanhineva Kati. 2015. Molecular nutrition and food research. 59: 1550-1562 A1 Journal article (refereed), original research -
Application of Mass Spectrometry in Unravelling the Secrets of the Endocannabinoid System
Lehtonen Marko. 2015. Publications of the University of Eastern Finland. Dissertations in Health Sciences G5 Doctoral dissertation (article) -
CMPF Does Not Associate with Impaired Glucose Metabolism in Individuals with Features of Metabolic Syndrome
Lankinen Maria A., Hanhineva Kati, Kolehmainen Marjukka, Lehtonen Marko, Auriola Seppo, Mykkänen Hannu, Poutanen Kaisa, Schwab Ursula, Uusitupa Matti. 2015. PLoS ONE. 10: e0124379 A1 Journal article (refereed), original research -
Increased tonic cannabinoid CB1R activity and brain region-specific desensitization of CB1R Gi/o signaling axis in mice with global genetic knockout of monoacylglycerol lipase
Navia-Paldanius Dina, Aaltonen Niina, Lehtonen Marko, Savinainen Juha R, Taschler Ulrike, Radner Franz PW, Zimmermann Robert, Laitinen Jarmo T. 2015. European journal of pharmaceutical sciences. 77: 180-188 A1 Journal article (refereed), original research -
Nontargeted Metabolite Profiles and Sensory Properties of Strawberry Cultivars Grown both Organically and Conventionally
Kårlund Anna, Hanhineva Kati, Lehtonen Marko, Karjalainen Reijo O, Sandell Mari. 2015. Journal of agricultural and food chemistry. 63: 1010-1019 A1 Journal article (refereed), original research -
Systematic in vitro and in vivo study on porous silicon to improve the oral bioavailability of celecoxib
Riikonen Joakim, Correia Alexandra, Kovalainen Miia, Näkki Simo, Lehtonen Marko, Leppänen Jukka, Rantanen Jimi, Xu Wujun, Araújo Francisca, Hirvonen Jouni, Järvinen Kristiina, Santos Hélder A, Lehto Vesa-Pekka. 2015. Biomaterials. 52: 44-55 A1 Journal article (refereed), original research -
Brain Pharmacokinetics of Ganciclovir in Rats with Orthotopic BT4C Glioma
Gynther Mikko, Kääriäinen Tiina M, Hakkarainen Jenni J, Jalkanen Aaro J, Petsalo Aleksanteri, Lehtonen Marko, Peura Lauri, Kurkipuro Jere, Samaranayake Haritha, Yla-Herttuala Seppo, Rautio Jarkko, Forsberg Markus M. 2014. Drug metabolism and disposition. 2015; 43: 140-146 A1 Journal article (refereed), original research -
Discovery of triterpenoids as reversible inhibitors of alpha/ß-hydrolase domain containing 12 (ABHD12)
Parkkari Teija, Haavikko Raisa, Laitinen Tuomo, Navia-Paldanius Dina, Rytilahti Roosa, Vaara Miia, Lehtonen Marko, Alakurtti Sami, Yli-Kauhaluoma Jari, Nevalainen Tapio, Savinainen Juha R, Laitinen Jarmo T. 2014. PLoS ONE. 9: e98286 A1 Journal article (refereed), original research -
Nontargeted metabolite profiling discriminates diet-specific biomarkers for consumption of whole grains, fatty fish, and bilberries in a randomized controlled trial
Hanhineva Kati, Lankinen Maria A, Pedret Anna, Schwab Ursula, Kolehmainen Marjukka, Paananen Jussi, de Mello Vanessa, Sola Rosa, Lehtonen Marko, Poutanen Kaisa, Uusitupa Matti, Mykkänen Hannu. 2014. Journal of nutrition. 2015; 145: 7-17 A1 Journal article (refereed), original research -
Robust hydrolysis of prostaglandin glycerol esters by human monoacylglycerol lipase (MAGL)
Savinainen Juha R, Kansanen Emilia, Pantsar Tatu, Navia-Paldanius Dina, Parkkari Teija, Lehtonen Marko, Laitinen Tuomo, Nevalainen Tapio, Poso Antti, Levonen Anna-Liisa, Laitinen Jarmo T. 2014. Molecular pharmacology. Epub ahead of print: - A1 Journal article (refereed), original research -
Validation of a multipoint near-infrared spectroscopy method for in-line moisture content analysis during freeze-drying
Kauppinen Ari, Toiviainen Maunu, Lehtonen Marko, Järvinen Kristiina, Paaso Janne, Juuti Mikko, Ketolainen Jarkko. 2014. Journal of pharmaceutical and biomedical analysis. 95: 229-237 A1 Journal article (refereed), original research -
Validation of a multipoint near-infrared spectroscopy method for in-line moisture content determination during freeze-drying
Kauppinen Ari, Toiviainen Maunu, Lehtonen Marko, Järvinen Kristiina, Paaso Janne, Juuti Mikko, Ketolainen Jarkko. 2014. -
Betaine supplementation causes increase in carnitine metabolites in the muscle and liver of mice fed a high-fat diet as studied by nontargeted LC-MS metabolomics approach
Pekkinen Jenna, Olli Kaisa, Huotari Anne, Tiihonen Kirsti, Keski-Rahkonen Pekka, Lehtonen Marko, Auriola Seppo, Kolehmainen Marjukka, Mykkänen Hannu, Poutanen Kaisa, Hanhineva Kati. 2013. Molecular nutrition and food research. 57: 1959-1968 A1 Journal article (refereed), original research -
Brain regional cannabinoid CB1 receptor signalling and alternative enzymatic pathways for 2-arachidonoylglycerol generation in brain sections of diacylglycerol lipase deficient mice
Aaltonen Niina, Ribas Casandra R, Lehtonen Marko, Savinainen Juha R, Laitinen Jarmo T. 2013. European journal of pharmaceutical sciences. 2014:51: 87-95 A1 Journal article (refereed), original research -
Endogenous cannabinoids in amygdala and hippocampus in post-mortem brains of Cloninger type 1 and 2 alcoholics
Kärkkäinen Olli K, Lehtonen Marko, Laukkanen Virpi, Tupala Erkki, Hyytiä Petri, Kautiainen Hannu, Tiihonen Jari, Callaway JC, Storvik Markus. 2013. Alcohol. 47: 399-403 A1 Journal article (refereed), original research -
Piperazine and piperidine triazole ureas as ultrapotent and highly selective inhibitors of monoacylglycerol lipase
Aaltonen Niina, Savinainen Juha R, Ribas Casandra R, Rönkkö Jani, Kuusisto Anne, Korhonen Jani, Navia-Paldanius Dina, Häyrinen Jukka, Takabe Piia, Käsnänen Heikki, Pantsar Tatu, Laitinen Tuomo, Lehtonen Marko, Pasonen-Seppänen Sanna, Poso Antti, Nevalainen Tapio, Laitinen Jarmo T. 2013. Chemistry and biology. 20: 379-390 A1 Journal article (refereed), original research -
Quantification of endocannabinoids in postmortem brain of schizophrenic subjects
Muguruza Carolina, Lehtonen Marko, Aaltonen Niina, Morentin Benito, Meana J. Javier, Callado Luis F. 2013. Schizophrenia research. 148: 145-150 A1 Journal article (refereed), original research -
Stability of an epidural analgesic admixture of levobupivacaine, fentanyl and epinephrine
Helin-Tanninen Minna, Lehtonen Marko, Naaranlahti Toivo, Venäläinen Tetta, Pentikäinen J, Laatikainen A, Kokki Hannu. 2013. Journal of clinical pharmacy and therapeutics. 38: 104-108 A1 Journal article (refereed), original research -
Validation of a multipoint near-infrared spectroscopy method for in-line moisture content determination during freeze-drying
Kauppinen Ari, Toiviainen Maunu, Lehtonen Marko, Järvinen Kristiina, Paaso Janne, Juuti Mikko, Ketolainen Jarkko. 2013. EUFEPS -
Lipid phosphate phosphatase inhibitors locally amplify lysophosphatidic acid LPA1 receptor signalling in rat brain cryosections without affecting global LPA degradation
Aaltonen Niina, Lehtonen Marko, Varonen Katri, Goterris Gemma Arrufat, Laitinen Jarmo T. 2012. Bmc pharmacology. 12: 7 A1 Journal article (refereed), original research -
Plasma and cerebrospinal fluid pharmacokinetics of naproxen in children
Välitalo Pyry, Kumpulainen Elina, Manner Minna, Kokki Merja, Lehtonen Marko, Hooker Andrew C, Ranta Veli-Pekka, Kokki Hannu. 2012. Journal of clinical pharmacology. 52: 1516-1526 A1 Journal article (refereed), original research -
The effect of hydroxypropyl-beta-cyclodextrin and sucrose on the sublingual absorption of midazolam in rabbits
Kaartama Ruut, Turunen Elina, Toljamo Kirsi, Kokki Hannu, Lehtonen Marko, Ranta Veli-Pekka, Savolainen Jouko, Järvinen Kristiina, Jarho Pekka. 2012. European journal of pharmaceutics and biopharmaceutics. 81: 178-183 A1 Journal article (refereed), original research -
Brain pharmacokinetics of two prolyl oligopeptidase inhibitors, JTP-4819 and KYP-2047, in the rat
Jalkanen Aaro J, Hakkarainen Jenni J, Lehtonen Marko, Venäläinen Tetta, Kääriäinen Tiina M, Jarho Elina, Suhonen Marjukka, Forsberg Markus M. 2011. Basic and clinical pharmacology and toxicology. 109: 443-451 A1 Journal article (refereed), original research -
Caenorhabditis elegans mutants predict regulation of fatty acids and endocannabinoids by the CYP-35A gene family
Aarnio Vuokko, Lehtonen Marko, Storvik Markus, Callaway James C, Lakso Merja, Wong Garry. 2011. Frontiers in pharmacology. 2: 1-10 A1 Journal article (refereed), original research -
Determination of endocannabinoids in nematodes and human brain tissue by liquid chromatography electrospray ionization tandem mass spectrometry
Lehtonen Marko, Storvik Markus, Malinen Hanna, Hyytiä Petri, Lakso Merja, Auriola Seppo, Wong Garry, Callaway James. 2011. Journal of chromatography b: analytical technologies in the biomedical and life sciences. 879: 677 - 694 A1 Journal article (refereed), original research -
Determination of midazolam and 1-hydroxymidazolam from plasma by gas chromatography coupled to methane negative chemical ionization mass spectrometry after sublingual administration of midazolam
Kaartama Ruut, Jarho Pekka, Savolainen Jouko, Kokki Hannu, Lehtonen Marko. 2011. Journal of chromatography b: analytical technologies in the biomedical and life sciences. 879: 1668 - 1676 A1 Journal article (refereed), original research -
Effects of memantine and donepezil on cortical and hippocampal acetylcholine levels and object recognition memory in rats
Ihalainen Jouni, Sarajärvi Timo, Rasmusson Doug, Kemppainen Susanna, Keski-Rahkonen Pekka, Lehtonen Marko, Banerjee Pradeep K, Semba Kazue, Tanila Heikki. 2011. Neuropharmacology. 61: 891-899 A1 Journal article (refereed), original research -
Trans fat diet causes decreased brood size and shortened lifespan in Caenorhabditis elegans delta-6-desaturase mutant fat-3
Reisner Kaja, Lehtonen Marko, Storvik Markus, Jantson Tanel, Lakso Merja, Callaway James C, Wong Garry. 2011. Journal of biochemical and molecular toxicology. 25: 269-279 A1 Journal article (refereed), original research -
A novel delayed non-match to sample object recognition task that allows simultaneous in vivo microdialysis
Ihalainen J, Sarajärvi T, Kemppainen S, Keski-Rahkonen P, Lehtonen M & Tanila H. 2010. Journal of neuroscience methods. 189: 210 - 215 A1 Journal article (refereed), original research -
Brain uptake of ketoprofen-lysine prodrug in rats
Gynther M, Jalkanen A, Lehtonen M, Forsberg M, Laine K, Ropponen J, Leppänen J, Knuuti J & Rautio J. 2010. International journal of pharmaceutics. 399: 121-128 A1 Journal article (refereed), original research -
Celastrol: Molecular targets of Thunder God Vine
Salminen A, Lehtonen M, Paimela T & Kaarniranta K. 2010. Biochemical and biophysical research communications. 394: 439 - 442 A2 Review article, Literature review, Systematic review -
Design, synthesis and in vitro/in vivo evaluation of orally bioavailable prodrugs of a catechol-O-methyltransferase inhibitor
Rautio J, Leppänen J, Lehtonen M, Laine K, Koskinen M, Pystynen J, Savolainen J & Sairanen M. 2010. Bioorganic and medicinal chemistry letters. 20: 2614 - 2616 A1 Journal article (refereed), original research -
Endogenous cannabinoids in post-mortem brains of Cloninger type 1 and 2 alcoholics
Lehtonen M, Storvik M, Tupala E, Hyytiä P, Tiihonen J & Callaway JC. 2010. European neuropsychopharmacology. 20: 245 - 252 A1 Journal article (refereed), original research -
Fatty acid composition and gene expression profiles are altered in aryl hydrocarbon receptor-1 mutant Caenorhabditis elegans
Aarnio V, Storvik M, Lehtonen M, Asikainen S, Reisner K, Callaway J, Rudgalvyte M, Lakso M & Wong G. 2010. Comparative biochemistry and physiology c: toxicology and pharmacology. 151: 318 - 324 A1 Journal article (refereed), original research -
Plasma and cerebrospinal fluid pharmacokinetics of flurbiprofen in children
Kumpulainen E, Välitalo P, Kokki M, Lehtonen M, Hooker A, Ranta V-P & Kokki H. 2010. British journal of clinical pharmacology. 70: 557-566 A1 Journal article (refereed), original research -
Quantification of lysophosphatidic acids in rat brain tissue by liquid chromatography-electrospray tandem mass spectrometry
Aaltonen N, Laitinen JT & Lehtonen M. 2010. Journal of chromatography b: analytical technologies in the biomedical and life sciences. 878: 1145 - 1152 A1 Journal article (refereed), original research -
Cannabinoid type 1 receptors in human skeletal muscle cells participate in the negative crosstalk between fat and muscle
Eckardt K, Sell H, Taube A, Koenen M, Platzbecker B, Cramer A, Horrighs A, Lehtonen M, Tennagels N, Eckel J. 2009. Diabetologia. 52: 664-674 A1 Journal article (refereed), original research -
Modulation of brain endocannabinoid levels by voluntary alcohol consumption in alcohol-preferring AA rats
Malinen H, Lehtonen M, Hyytiä Petri. 2009. Alcoholism-clinical and experimental research. 33: 1711-1720 A1 Journal article (refereed), original research -
Development and validation of a gas chromatographic-mass spectrometric method for quantitative determination of perphenazine in rabbit plasma after sublingual administration
Turunen E, Lehtonen M, Järvinen T, Jarho P. 2008. Journal of chromatography b: analytical technologies in the biomedical and life sciences. 872: 51-57 A1 Journal article (refereed), original research -
Diclofenac readily penetrates the cerebrospinal fluid in children
Kokki H, Kumpulainen E, Laisalmi M, Savolainen J, Rautio J, Lehtonen M. 2008. British journal of clinical pharmacology. 65: 879-884 A1 Journal article (refereed), original research -
How readily does ketorolac penetrate cerebrospinal fluid in children?
Kumpulainen E, Kokki H, Laisalmi M, Heikkinen M, Savolainen J, Rautio J, Lehtonen M. 2008. Journal of clinical pharmacology. 48: 495-501 A1 Journal article (refereed), original research -
Mass-spectrometric identification of anandamide and 2-arachidonoylglycerol in nematodes
Lehtonen M, Reisner K, Auriola S, Wong G, Callaway JC. 2008. Chemistry and biodiversity. 5: 2431-2441 A1 Journal article (refereed), original research -
Quantitative analysis of natural cyclodextrins by high-performance liquid chromatography with pulsed amperometric detection: Application to cell permeation study
Toropainen T, Jarho P, Lehtonen M, Keski-Rahkonen P, Raatikainen H, Järvinen T. 2008. Journal of chromatography b: analytical technologies in the biomedical and life sciences. 867: 90-98 A1 Journal article (refereed), original research -
Simultaneous determination of acrylamide, its metabolite glycidamide and antipyrine in human placental perfusion fluid and placental tissue by liquid chromatography-electrospray tandem mass spectrometry
Annola K, Keski-Rahkonen P, Vähäkangas K, Lehtonen M. 2008. Journal of chromatography b: analytical technologies in the biomedical and life sciences. 876: 191-197 A1 Journal article (refereed), original research -
Terpenoids: natural inhibitors of NF-kappaB signaling with anti-inflammatory and anticancer potential
Salminen A, Lehtonen M, Suuronen T, Kaarniranta K, Huuskonen J. 2008. Cellular and molecular life sciences. 65: 2979-2999 A2 Review article, Literature review, Systematic review -
Cerebrospinal fluid distribution of ibuprofen after intravenous administration in children
Kokki H, Kumpulainen E, Lehtonen M, Laisalmi M, Heikkinen M, Savolainen J, Rautio J. 2007. Pediatrics. 120: e1002-e1008 A1 Journal article (refereed), original research -
Comparison of the effects of deramciclane, ritanserin and buspirone on extracellular dopamine and its metabolites in striatum and nucleus accumbens of freely moving rats
Kääriäinen TM, Lehtonen M, Forsberg MM, Savolainen J, Käenmäki M, Männistö PT. 2007. Basic and clinical pharmacology and toxicology. 102: 50-58 A1 Journal article (refereed), original research -
Determination of tamsulosin in human aqueous humor and serum by liquid chromatography - electrospray ionization tandem mass spectrometry
Keski-Rahkonen P, Pärssinen O, Leppänen E, Mauriala T, Lehtonen M, Auriola S. 2007. Journal of pharmaceutical and biomedical analysis. 43: 606-612 A1 Journal article (refereed), original research -
Early-phase pharmacokinetics of enteral and parenteral nimodipine in patients with acute subarachnoid haemorrhage - a pilot study
Soppi V, Kokki H, Koivisto T, Lehtonen M, Helin-Tanninen M, Lehtola S, Rinne J. 2007. European journal of clinical pharmacology. 63: 355-361 A1 Journal article (refereed), original research -
Plasma and cerebrospinal fluid concentrations of indomethacin in children after intravenous administration
Mannila A, Kumpulainen E, Lehtonen M, Heikkinen M, Laisalmi M, Salo T, Rautio J, Savolainen J, Kokki H. 2007. Journal of clinical pharmacology. 47: 94-100 A1 Journal article (refereed), original research -
Quantitative determination of acetylcholine in microdialysis samples using liquid chromatography/atmospheric pressure spray ionization mass spectrometry
Keski-Rahkonen P, Lehtonen M, Ihalainen J, Sarajärvi T, Auriola S. 2007. Rapid communications in mass spectrometry. 21: 2933-2943 A1 Journal article (refereed), original research -
Visualization of 2-arachidonoylglycerol accumulation and cannabinoid CB1 receptor activity in rat brain cryosections by functional autoradiography
Palomäki VAB, Lehtonen M, Savinainen JR, Laitinen JT. 2007. Journal of neurochemistry. 101: 972-981 A1 Journal article (refereed), original research -
Cerebrospinal fluid distribution of ketoprofen after intravenous administration in young children
Mannila A, Kokki H, Heikkinen M, Laisalmi M, Lehtonen M, Louhisto HL, Järvinen T, Savolainen J. 2006. Clinical pharmacokinetics. 45: 737-743 A1 Journal article (refereed), original research -
Controlled release of saccharides from matrix tablets
Mäki R, Suihko E, Korhonen O, Pitkänen H, Niemi R, Lehtonen M, Ketolainen J. 2006. European journal of pharmaceutics and biopharmaceutics. 62: 163-170 A1 Journal article (refereed), original research -
Convenient microwave-assisted synthesis of 1-chloroethyl phosphates
Kumpulainen H, Saari R, Lehtonen M, Rautio J, Järvinen T, Vepsäläinen J. 2006. Tetrahedron letters. 47: 2003-2004 A1 Journal article (refereed), original research -
Influence of tamsulosin on the iris and its implications for cataract surgery
Pärssinen O, Leppänen E, Keski-Rahkonen P, Mauriala T, Dugué B, Lehtonen M. 2006. Investigative ophthalmology and visual science. 47: 3766-3771 A1 Journal article (refereed), original research -
URB754 has no effect on the hydrolysis or signaling capacity of 2-AG in the rat brain
Saario SM, Palomäki V, Lehtonen M, Nevalainen T, Järvinen T, Laitinen JT. 2006. Chemistry and biology. 13: 811-814 A1 Journal article (refereed), original research -
An efficient strategy for the synthesis of 1-chloroethyl phosphates and phosphoramidates
Kumpulainen H, Järvinen T, Saari R, Lehtonen M, Vepsäläinen J. 2005. Journal of organic chemistry. 70: 9056-9058 A1 Journal article (refereed), original research -
Inefficient central nervous system delivery limits the use of ibuprofen in neurodegenerative diseases
Mannila A, Rautio J, Lehtonen M, Järvinen T, Savolainen J. 2005. European journal of pharmaceutical sciences. 24: 101-105 A1 Journal article (refereed), original research -
Determination of delta9 -tetrahydrocannabinol from rabbit plasma by gas chromatography-mass spectrometry using two ionization techniques
Mannila J, Lehtonen M, Järvinen T, Jarho P. 2004. Journal of chromatography b: analytical technologies in the biomedical and life sciences. 810: 283-290 A1 Journal article (refereed), original research -
Pharmacokinetics and pharmacodynamics of entacapone and tolcapone after acute and repeated administration: a comparative study in the rat
Forsberg M, Lehtonen M, Heikkinen M, Savolainen J, Järvinen T, Männistö PT. 2003. Journal of pharmacology and experimental therapeutics. 304: 498-506 A1 Journal article (refereed), original research