Prasanthi Medarametla
Academy Research Fellow
Antibacterial drug discovery by targeting virulence and pathogenicity
School of Pharmacy, Faculty of Health Sciences
Prasanthi Medarametla is an Academy Research Fellow at the School of Pharmacy, University of Eastern Finland. She obtained her Bachelor’s degree in Pharmaceutical Sciences and a Master’s degree in Pharmacoinformatics from NIPER, India. She then worked as a Project Associate and TATA–CSIR–OSDD Fellow at the Indian Institute of Chemical Technology, Hyderabad.
Prasanthi was a Marie Skłodowska‑Curie Early Stage Researcher in the EU‑MSCA ITN project INTEGRATE (Interdisciplinary Training Network for Validation of Gram‑Negative Antibacterial Targets). She completed her PhD at the University of Eastern Finland, Kuopio, in 2020, where she focused on computational screening of novel antibacterials within the INTEGRATE project.
In 2022, she joined the University of Cambridge as a Postdoctoral Researcher with support from the Postdoc Pooli (Jenny and Antti Wihuri Foundation), gaining expertise in experimental microbiology and structural biology techniques, including cryo‑EM and X‑ray crystallography. She later returned to UEF and worked as a Senior Researcher in the Biopharmacy Department before receiving an Academy Research Fellow position in 2025.
Currently, she leads the AVID (Anti‑Virulence Drug Discovery) research group at UEF and serves as the leader of the NORDFORSK NORD‑AViD consortium.
If you’re interested in Master’s projects or planning to pursue a PhD related to antibacterial protein targets and the mechanisms underlying bacterial virulence, feel free to reach out—I’d be happy to discuss potential opportunities.
Research groups
Article related to our research
Publications
11/11 items-
A Twist of Fate: The Helix–Turn–Helix Motif in Pseudomonas aeruginosa ExsA Can Allosterically Stabilize the Ligand-Binding Domain
Medarametla, Prasanthi; Greenhalgh, Jack Calum; Pöhner, Ina; Welch, Martin; Poso, Antti; Kronenberger, Thales; Rahman, Taufiq, 2025, Journal of chemical information and modeling, 65, 22, 12448-12463. A1 Journal article (refereed), original research -
Look What You Made Me Do: Discerning Feature for Classification of Endocrine-Disrupting Chemical Binding to Steroid Hormone Receptors
Rashidian, Azam; Pitkänen, Sini; Maltarollo, Vinicius Goncalves; Schoppmeier, Ulrich; Shevchenko, Ekaterina; Medarametla, Prasanthi; Poso, Antti; Küblbeck, Jenni; Honkakoski, Paavo; Kronenberger, Thales, 2025, Journal of chemical information and modeling, 65, 8, 4148-4162. A1 Journal article (refereed), original research -
Pseudomonas aeruginosa acyl-CoA dehydrogenases and structure-guided inversion of their substrate specificity
Wang, Meng; Medarametla, Prasanthi; Kronenberger, Thales; Deingruber, Tomas; Brear, Paul; Figueroa, Wendy; Ho, Pok-Man; Krueger, Thomas; Pearce, James C.; Poso, Antti; Wakefield, James G.; Spring, David R.; Welch, Martin, 2025, Nature communications, 16, 1, 2334. A1 Journal article (refereed), original research -
Stoichiometric transport of estrone 3-sulfate among genetic variants of OATP1A2 and OATP2B1 and structural analysis by molecular dynamics simulation: Impairment of gating mechanism in the unstable inward-open conformation of OATP2B1 (Asp215Val) significantly suppress the transport activity
Akiyoshi, Takeshi; Tonduru, Arun Kumar; Kataoka, Hiroki; Morita, Tokio; Yajima, Kodai; Imaoka, Ayuko; Katayama, Kazuhiro; Medarametla, Prasanthi; Uchida, Yasuo; Poso, Antti; Ohtani, Hisakazu; Terasaki, Tetsuya, 2025, Drug metabolism and disposition, 53, 12, 100198. A1 Journal article (refereed), original research -
Structural Characterization of LsrK as a Quorum Sensing Target and a Comparison between X-ray and Homology Models
Medarametla, Prasanthi; Kronenberger, Thales; Laitinen, Tuomo; Poso, Antti, 2021, Journal of chemical information and modeling, 61, 3, 1346-1353. A1 Journal article (refereed), original research -
Identification and Design of New Antibacterial Agents Using Computational Approaches
Medarametla, Prasanthi, 2020, Publications of the University of Eastern Finland. Dissertations in Health Sciences. G4 Doctoral dissertation (monograph) -
DPD-Inspired Discovery of Novel LsrK Kinase Inhibitors: An Opportunity To Fight Antimicrobial Resistance
Stotani, Silvia; Gatta, Viviana; Medarametla, Prasanthi; Padmanaban, Mohan; Karawajczyk, Anna; Giordanetto, Fabrizio; Tammela, Päivi; Laitinen, Tuomo; Poso, Antti; Tzalis, Dimitros; Collina, Simona, 2019, Journal of medicinal chemistry, 62, 5, 2720-2737. A1 Journal article (refereed), original research -
Molecular Modelling Approaches to Antibacterial Drug Design and Discovery
Kaczor, Agnieszka A; Medarametla, Prasanthi; Bartuzi, Damian; Kondej, Magdalena; Matosiuk, Dariusz; Poso, Antti, 2018, Rahman, Atta-ur; Choudhary, Iqbal M, Frontiers in Anti-Infective Drug Discovery, 153-222. B2 Book section -
Structure-based virtual screening of LsrK kinase inhibitors to target quorum sensing
Medarametla, Prasanthi; Gatta, Viviana; Kajander, Tommi; Laitinen, Tuomo; Tammela, Päivi; Poso Antti, 2018, Chemmedchem, 13, 22, 2400-2407. A1 Journal article (refereed), original research -
A QSAR and molecular modelling study towards new lead finding: polypharmacological approach to Mycobacterium tuberculosis
Janardhan S, John L, Prasanthi M, Poroikov V, Narahari Sastry G, 2017, Sar and qsar in environmental research, 28, 10, 815-832. A1 Journal article (refereed), original research

