Metabolism and transport of drugs and xenobiotics

Research group

Our research is focused important cytochrome P450 and conjugation enzymes, hepatic transporters and nuclear receptors that regulate these proteins.

Individuals are continuously exposed to myriad of foreign compounds derived from the diet, environmental pollutants and drugs (xenobiotics). Metabolic enzymes in the body usually convert xenobiotics to more water-soluble and less harmful metabolites although enzymatic reactions may also produce reactive, toxic products. Transport proteins aid in transfer of xenobiotics and their metabolites across cell membranes and excrete them out of the body. Exposure to xenobiotics can either block the activity of metabolic enzymes and transporters (inhibition) or enhance their expression levels (induction).

Keywords

Group members - UEF

Publications by the research group members