
Niskanen Group: Regulatory mechanisms of steroid receptors
Leaders
Synthetic glucocorticoids (GCs) are potent anti-inflammatory drugs that are used to treat various inflammatory diseases, including asthma and rheumatoid arthritis. Prolonged medical use of GCs is however hindered by the adverse side effects that can lead to e.g. diabetes and osteoporosis. GCs function by activating a transcription factor, GC receptor, which induces and represses genes. Anti-inflammatory actions of GCs are result from repression of inflammatory genes, while the side effects arise from activation of metabolic genes. While the mechanisms of gene induction in GC signaling are relatively well characterized, those of gene repression are not.
Cooperation
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Professor
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Academy Research Fellow
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Professor , Biomedicine
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Academy Research Fellow
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University Researcher, Adjunct Professor in Cancer Biology
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Academy of Finland Postdoctoral Researcher
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Academy Research Fellow, Assistant Professor of Health Bioinformatics (tenure track)
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University Lecturer
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Assistant Professor in Next Generation Gene Therapy (Tenure track)
Keywords
Publications
15 items-
BCOR modulates transcriptional activity of a subset of glucocorticoid receptor target genes involved in cell growth and mobility
Manjur, ABMK; Lempiäinen, JK; Malinen, M; Varjosalo, M; Palvimo, JJ; Niskanen, EA. 2021. Journal of steroid biochemistry and molecular biology. 210: 105873 -
Chromatin-directed proteomics-identified network of endogenous androgen receptor in prostate cancer cells
Launonen, Kaisa-Mari; Paakinaho, Ville; Sigismondo, Gianluca; Malinen, Marjo; Sironen, Reijo; Hartikainen, Jaana M; Laakso, Hanna; Visakorpi, Tapio; Krijgsveld, Jeroen; Niskanen, Einari A; Palvimo, Jorma J. 2021. Oncogene. 40: 4567-4579 -
SUMOylation regulates the protein network and chromatin accessibility at glucocorticoid receptor-binding sites
Paakinaho, Ville; Lempiäinen, Joanna K; Sigismondo, Gianluca; Niskanen, Einari A; Malinen, Marjo; Jääskeläinen, Tiina; Varjosalo, Markku; Krijgsveld, Jeroen; Palvimo, Jorma J. 2021. Nucleic acids research. 49: 1951-1971 -
Stress-induced nuclear condensation of NELF drives transcriptional downregulation
Rawat, Prashant; Boehning, Marc; Hummel, Barbara; Aprile-Garcia, Fernando; Pandit, Anwit S; Eisenhardt, Nathalie; Khavaran, Ashkan; Niskanen, Einari; Vos, Seychelle M; Palvimo, Jorma J; Pichler, Andrea; Cramer, Patrick; Sawarkar, Ritwick. 2021. Molecular cell. 81: 1013-1026 -
BCOR-coupled H2A monoubiquitination represses a subset of androgen receptor target genes regulating prostate cancer proliferation
Lempiäinen, JK; Manjur, ABMK; Malinen, M; Ketola, K; Niskanen, EA; Palvimo, JJ. 2020. Oncogene. 39: 2391-2407 -
Histonien muokkaukset ja geenien säätely
Sutinen, Siiri; Niskanen, Einari. 2020. Solubiologi. : 12-21 -
IRF2BP2 Modulates the Crosstalk between Glucocorticoid and TNF Signaling
Kaiser Manjur, ABM; Lempiäinen, Joanna K; Malinen, Marjo; Palvimo, Jorma J; Niskanen, Einari A. 2019. Journal of steroid biochemistry and molecular biology. 192: 105382 -
Lack of androgen receptor SUMOylation results in male infertility due to epididymal dysfunction
Zhang, Fu-Ping; Malinen, Marjo; Mehmood, Arfa; Lehtiniemi, Tiina; Jääskeläinen, Tiina; Niskanen, Einari A; Korhonen, Hanna; Laiho, Asta; Elo, Laura L; Ohlsson, Claes; Kotaja, Noora; Poutanen, Matti; Sipilä, Petra; Palvimo, Jorma J. 2019. Nature communications. 10: 777 -
Agonist-specific Protein Interactomes of Glucocorticoid and Androgen Receptor as Revealed by Proximity Mapping
Lempiäinen Joanna K, Niskanen Einari A, Vuoti Kaisa-Mari, Lampinen Riikka E, Göös Helka, Varjosalo Markku, Palvimo Jorma J. 2017. Molecular and cellular proteomics. 16: 1462-1474 -
Chromatin SUMOylation in heat stress : to protect, pause and organise?
Niskanen Einari A, Palvimo Jorma J. 2017. Bioessays. 39: 1600263