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Regulatory mechanisms of steroid receptors - Niskanen lab´s Profile image

Regulatory mechanisms of steroid receptors - Niskanen lab

Research group
01.09.2020 -
Institute of Biomedicine, School of Medicine, Faculty of Health Sciences
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Our aim is to understand how coregulators influence transcriptional regulation. As models, we use cortisol and inflammatory signaling pathways, that can be induced on demand.

Synthetic glucocorticoids (GCs) are potent anti-inflammatory drugs that are used to treat various inflammatory diseases, including asthma and rheumatoid arthritis. Prolonged medical use of GCs is however hindered by the adverse side effects that can lead to e.g. diabetes and osteoporosis. GCs function by activating a transcription factor, GC receptor, which induces and represses genes. Anti-inflammatory actions of GCs are result from repression of inflammatory genes, while the side effects arise from activation of metabolic genes. While the mechanisms of gene induction in GC signaling are relatively well characterized, those of gene repression are not.

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Keywords

androgen androgen receptor auxin-induced degradation bioinformatics colorectal cancer coregulators gene expression gene regulation glucocorticoid glucocorticoid receptor inflammatory response macrophages transcription transcription factor transcription regulation transcription repression transcriptional gene activation

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