Seppo Auriola
Professor
Teaching of analytical chemistry. Research: Pharmaceutical analysis, mass spectrometry, metabolomics
School of Pharmacy, Faculty of Health Sciences
seppo.auriola@uef.fi | +358 40 355 2469
Research groups
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Analytical unit of the school of Pharmacy 27.02.2020 - -
LC-MS metabolomics center 01.09.2023 - -
Microplastic research 01.09.2016 - -
Ocular Drug Delivery group (ODD) 01.01.2010 -
Projects
Keywords
Publications
230/230 items-
Accelerated early childhood growth associates with the development of earlier adrenarche and puberty
Liimatta, Jani; Jääskeläinen, Jarmo; Mäntyselkä, Aino; Häkkinen, Merja R; Auriola, Seppo; Voutilainen, Raimo; Flück, Christa E; Lakka, Timo A. 2024. Journal of the Endocrine Society. 8: . bvae026 A1 Journal article (refereed), original research -
Barcode lipids for absolute quantitation of liposomes in ocular tissues
Merivaara, Arto; Puranen, Jooseppi; Sadeghi, Amir; Zashikhina, Natalia; Pirskanen, Lea; Lajunen, Tatu; Terasaki, Tetsuya; Auriola, Seppo; Vellonen, Kati Sisko; Urtti, Arto. 2024. Journal of controlled release. 370: 1-13 A1 Journal article (refereed), original research -
Biotransformation of nanoplastics in human plasma and their permeation through a model in vitro blood-brain barrier: An in-depth quantitative analysis
Abdolahpur Monikh, Fazel; Lehtonen, Šárka; Kekäläinen, Jukka; Karkossa, Isabel; Auriola, Seppo; Schubert, Kristin; Zanut, Alessandra; Peltonen, Sanni; Niskanen, Jonna; Bandekar, Mandar; von Bergen, Martin; Leskinen, Jari TT; Koistinen, Arto; Bogialli, Sara; Guo, Zhiling; Kukkonen, Jussi VK; Chen, Chunying; Lynch, Iseult. 2024. Nano today. 59: . 102466 A1 Journal article (refereed), original research -
Eight-year Diet and Physical Activity Intervention Affects Serum Metabolites during Childhood & Adolescence: A Nonrandomized Controlled Trial
Zarei, Iman; Eloranta, Aino-Maija; Klåvus, Anton; Väistö, Juuso; Lehtonen, Marko; Mikkonen, Santtu; Koistinen, Ville M; Sallinen, Taisa; Haapala, Eero A; Lintu, Niina; Soininen, Sonja; Haikonen, Retu; Atalay, Mustafa; Schwab, Ursula; Auriola, Seppo; Kolehmainen, Marjukka; Hanhineva, Kati; Lakka, Timo A. 2024. iScience. 27: A1 Journal article (refereed), original research -
Longitudinal associations of an exposome score with serum metabolites from childhood to adolescence
Healy, Darren R; Zarei, Iman; Mikkonen, Santtu; Soininen, Sonja; Viitasalo, Anna; Haapala, Eero A; Auriola, Seppo; Hanhineva, Kati; Kolehmainen, Marjukka; Lakka, Timo A. 2024. Communications biology. 7: . 890 A1 Journal article (refereed), original research -
Profiling steroid hormone landscape of bladder cancer reveals depletion of intratumoural androgens to castration levels: a cross-sectional study
Kettunen, Kimmo; Mathlin, Julia; Lamminen, Tarja; Laiho, Asta; Häkkinen, Merja R; Auriola, Seppo; Elo, Laura L; Boström, Peter J; Poutanen, Matti; Taimen, Pekka. 2024. EBioMedicine. 108: A1 Journal article (refereed), original research -
Sex-specific changes in protein expression of membrane transporters in the brain cortex of 5xFAD mouse model of Alzheimer’s disease
Puris, Elena; Saveleva, Liudmila; Auriola, Seppo; Gynther, Mikko; Kanninen, Katja M; Fricker, Gert. 2024. Frontiers in pharmacology. 15: . 1365051 A1 Journal article (refereed), original research -
Transporter Protein Expression of Corneal Epithelium in Rabbit and Porcine: Evaluation of Models for Ocular Drug Transport Study
Ramsay, Eva; Montaser, Ahmed B; Niitsu, Kanako; Urtti, Arto; Auriola, Seppo; Huttunen, Kristiina M; Uchida, Yasuo; Kidron, Heidi; Terasaki, Tetsuya. 2024. Molecular pharmaceutics. 21: 3204-3217 A1 Journal article (refereed), original research -
An integrative analysis of endometrial steroid metabolism and transcriptome in relation to endometrial receptivity in IVF patients
Stevens Brentjens, LBPM; Obukhova, D; den Hartog, JE; Delvoux, B; Koskivuori, J; Auriola, S; Häkkinen, MR; Bui, B; van Hoogenhuijze, NE; Mackens, S; Mol, F; de Bruin, JP; Besselink, D; Teklenburg, G; Kukushkina, V; Salumets, A; Broekmans, FJM; van Golde, RJT; Zamani Esteki, M; Romano, A. 2023. F&S science. 4: 219-228 A1 Journal article (refereed), original research -
Characterization of an iPSC-based barrier model for blood-brain barrier investigations using the SBAD0201 stem cell line
Ozgür, Burak; Puris, Elena; Brachner, Andreas; Appelt-Menzel, Antje; Oerter, Sabrina; Balzer, Viktor; Holst, Mikkel Roland; Christiansen, Rasmus Folmann; Hyldig, Kathrine; Buckley, Stephen T; Kristensen, Mie; Auriola, Seppo; Jensen, Allan; Fricker, Gert; Nielsen, Morten Schallburg; Neuhaus, Winfried; Brodin, Birger. 2023. Fluids and barriers of the cns. 20: . 96 A1 Journal article (refereed), original research -
Comparative steroid profiling of newborn hair and umbilical cord serum highlights the role of fetal adrenals, placenta, and pregnancy outcomes in fetal steroid metabolism
Koskivuori, Johanna; Voutilainen, Raimo; Storvik, Markus; Hakkinen, Merja R.; Uusitalo, Lauri; Keski-Nisula, Leea; Backman, Katri; Auriola, Seppo; Lehtonen, Marko. 2023. Journal of steroid biochemistry and molecular biology. 232: A1 Journal article (refereed), original research -
Effects of 2-Year Physical Activity and Dietary Intervention on Adrenarchal and Pubertal Development: The PANIC Study
Liimatta, Jani; Flück, Christa E; Mäntyselkä, Aino; Häkkinen, Merja R; Auriola, Seppo; Voutilainen, Raimo; Jääskelainen, Jarmo; Lakka, Timo A. 2023. Journal of clinical endocrinology and metabolism. 108: e1603-e1613 A1 Journal article (refereed), original research -
Farmaseuttinen kemia
Jarho, Pekka; Lahtela-Kakkonen, Maija; Vepsäläinen, Jouko; Rautio, Jarkko; Huttunen, Kristiina; Poso, Antti; Auriola, Seppo. 2023. Publications of the University of Eastern Finland. General series. 44: 32-35 E1 Popularised article, newspaper article -
Functional Characterization of Six SLCO1B1 (OATP1B1) Variants Observed in Finnish Individuals with a Psychotic Disorder
Häkkinen, Katja; Kiander, Wilma; Kidron, Heidi; Lähteenvuo, Markku; Urpa, Lea; Lintunen, Jonne; Vellonen, Kati Sisko; Auriola, Seppo; Holm, Minna; Lahdensuo, Kaisla; Kampman, Olli; Isometsä, Erkki; Kieseppä, Tuula; Lönnqvist, Jouko; Suvisaari, Jaana; Hietala, Jarmo; Tiihonen, Jari; Palotie, Aarno; Ahola-Olli, Ari V.; Niemi, Mikko. 2023. Molecular pharmaceutics. 20: 1500-1508 A1 Journal article (refereed), original research -
In vitro identification of decreased function phenotype ABCG2 variants
Suominen, Laura; Sjöstedt, Noora; Vellonen, Kati-Sisko; Gynther, Mikko; Auriola, Seppo; Kidron, Heidi. 2023. European journal of pharmaceutical sciences. 188: A1 Journal article (refereed), original research -
Mass spectrometry in ocular drug research
del Amo, Eva M.; Vellonen, Kati‐Sisko; Urtti, Arto; Terasaki, Tetsuya; Hammid, Anam; Honkakoski, Paavo; Auriola, Seppo. 2023. Mass spectrometry reviews. [First published: 02 August 2023]: 1-32 A2 Review article, Literature review, Systematic review -
Monoacylglycerol lipase inhibitor JJKK048 ameliorates ABCG2 transporter-mediated regorafenib resistance induced by hypoxia in triple negative breast cancer cells
Puris, Elena; Petralla, Sabrina; Auriola, Seppo; Kidron, Heidi; Fricker, Gert; Gynther, Mikko. 2023. Journal of pharmaceutical sciences. 112: 2581-2590 A1 Journal article (refereed), original research -
A quantitative ultra-performance liquid chromatography high-resolution mass spectrometry analysis of steroids from human scalp hair
Koskivuori, Johanna; Voutilainen, Raimo; Uusitalo, Lauri; Lehtonen, Marko; Lakka, Timo; Auriola, Seppo; Häkkinen, Merja R. 2022. Journal of pharmaceutical and biomedical analysis. 215: A1 Journal article (refereed), original research -
Air Pollution Exposure Increases ABCB1 and ASCT1 Transporter Levels in Mouse Cortex
Puris, Elena; Saveleva, Liudmila; Górová, Veronika; Vartiainen, Petra; Kortelainen, Miika; Lamberg, Heikki; Sippula, Olli; Malm, Tarja; Jalava, Pasi I; Auriola, Seppo; Fricker, Gert; Kanninen, Katja M. 2022. Environmental toxicology and pharmacology. 96: A1 Journal article (refereed), original research -
Altered protein expression of membrane transporters in isolated cerebral microvessels and brain cortex of a rat Alzheimer's disease model
Puris, Elena; Auriola, Seppo; Petralla, Sabrina; Hartman, Robin; Gynther, Mikko; de Lange, Elizabeth CM; Fricker, Gert. 2022. Neurobiology of disease. 169: A1 Journal article (refereed), original research -
Aminopeptidase B can bioconvert L-type amino acid transporter 1 (LAT1)-utilizing amide prodrugs in the brain
Hugele, Agathe; Löffler, Susanne; Molina, Belén Hernández; Guillon, Melina; Montaser, Ahmed B.; Auriola, Seppo; Huttunen, Kristiina M.. 2022. Frontiers in pharmacology. 13: . 1034964 A1 Journal article (refereed), original research -
Enhanced drug delivery by a prodrug approach effectively relieves neuroinflammation in mice
Montaser, Ahmed B.; Kuiri, Janita; Natunen, Teemu; Hruška, Pavel; Potěšil, David; Auriola, Seppo; Hiltunen, Mikko; Terasaki, Tetsuya; Lehtonen, Marko; Jalkanen, Aaro; Huttunen, Kristiina M. 2022. Life sciences. 310: A1 Journal article (refereed), original research -
Functional in vitro characterization of SLCO1B1 variants and simulation of the clinical pharmacokinetic impact of impaired OATP1B1 function.
Wilma, Kiander; Noora, Sjöstedt; Riikka, Manninen; Liina, Jaakkonen; Kati-Sisko, Vellonen; Mikko, Neuvonen; Mikko, Niemi; Seppo, Auriola; Heidi, Kidron. 2022. European journal of pharmaceutical sciences. 176: A1 Journal article (refereed), original research -
In vitro metabolism of helenalin and its inhibitory effect on human cytochrome P450 activity
Šadibolová, Michaela; Juvonen, Risto O; Auriola, Seppo; Boušová, Iva. 2022. Archives of toxicology. 96: 793-808 A1 Journal article (refereed), original research -
Increased Expression and Activity of Brain Cortical cPLA2 Due to Chronic Lipopolysaccharide Administration in Mouse Model of Familial Alzheimer’s Disease
Gynther, Mikko; Estrada, Mariana Leal; Loppi, Sanna; Korhonen, Paula; Kanninen, Katja M.; Malm, Tarja; Koistinaho, Jari; Auriola, Seppo; Fricker, Gert; Puris, Elena. 2022. Pharmaceutics. 14: A1 Journal article (refereed), original research -
Mechanisms of cellular retention of melanin bound drugs: Experiments and computational modeling
Bahrpeyma, Sina; Reinisalo, Mika; Hellinen, Laura; Auriola, Seppo; del Amo, Eva M; Urtti, Arto. 2022. Journal of controlled release. 348: 760-770 A1 Journal article (refereed), original research -
Metabolomic, Lipidomic and Proteomic Characterisation of Lipopolysaccharide-induced Inflammation Mouse Model
Puris, Elena; Kouřil, Štěpán; Najdekr, Lukáš; Auriola, Seppo; Loppi, Sanna; Korhonen, Paula; Gómez-Budia, Mireia; Fricker, Gert; Kanninen, Katja M; Malm, Tarja; Friedecký, David; Gynther, Mikko. 2022. Neuroscience. 496: 165-178 A1 Journal article (refereed), original research -
Protein Expression of Amino Acid Transporters Is Altered in Isolated Cerebral Microvessels of 5xFAD Mouse Model of Alzheimer’s Disease
Puris, Elena; Saveleva, Liudmila; de Sousa Maciel, Izaque; Kanninen, Katja M.; Auriola, Seppo; Fricker, Gert. 2022. Molecular neurobiology. 2023; 60: 732-748 A1 Journal article (refereed), original research -
Re-evaluation of the hCMEC/D3 based in vitro BBB model for ABC transporter studies
Balzer, Viktor; Poc, Pascal; Puris, Elena; Martin, Stefan; Aliasgari, Maryam; Auriola, Seppo; Fricker, Gert. 2022. European journal of pharmaceutics and biopharmaceutics. 173: 12-21 A1 Journal article (refereed), original research -
Systemic inflammation elevates cytosolic prolyl oligopeptidase protein expression but not peptidase activity in the cerebral cortices of familial Alzheimer`s disease modeling mice
Puris, Elena; Jalkanen, Aaro; Auriola, Seppo; Loppi, Sanna; Korhonen, Paula; Kanninen, Katja M.; Malm, Tarja; Koistinaho, Jari; Gynther, Mikko. 2022. Brain disorders. 6: A1 Journal article (refereed), original research -
The Mediating Role of Endocrine Factors in the Positive Relationship Between Fat Mass and Bone Mineral Content in Children Aged 9–11 Years: The Physical Activity and Nutrition in Children Study
Constable, Annie M.; Vlachopoulos, Dimitris; Barker, Alan R.; Moore, Sarah A.; Soininen, Sonja; Haapala, Eero A.; Väistö, Juuso; Jääskeläinen, Jarmo; Voutilainen, Raimo; Auriola, Seppo; Häkkinen, Merja R.; Laitinen, Tomi; Lakka, Timo A.. 2022. Frontiers in endocrinology. 13: . 850448 A1 Journal article (refereed), original research -
Tissue-wide metabolomics reveals wide impact of gut microbiota on mice metabolite composition
Zarei, Iman; Koistinen, Ville M.; Kokla, Marietta; Klåvus, Anton; Babu, Ambrin Farizah; Lehtonen, Marko; Auriola, Seppo; Hanhineva, Kati. 2022. Scientific reports. 12: . 15018 A1 Journal article (refereed), original research -
A non-targeted LC-MS metabolic profiling of pregnancy: longitudinal evidence from healthy and pre-eclamptic pregnancies
Jääskeläinen, Tiina; Kärkkäinen, Olli; Jokkala, Jenna; Klåvus, Anton; Heinonen, Seppo; Auriola, Seppo; Lehtonen, Marko; The FINNPEC Core Investigator Group; Hanhineva, Kati; Laivuori, Hannele. 2021. Metabolomics. 17: 20 A1 Journal article (refereed), original research -
Atorvastatin induces adrenal androgen downshift in men with prostate cancer: A post Hoc analysis of a pilot adaptive Randomised clinical trial
Raittinen, Paavo V.H.; Syvälä, Heimo; Tammela, Teuvo L.J.; Häkkinen, Merja R.; Ilmonen, Pauliina; Auriola, Seppo; Murtola, Teemu J.. 2021. EBioMedicine. 68: 103432 A1 Journal article (refereed), original research -
Changes in the metabolic profile of human male postmortem frontal cortex and cerebrospinal fluid samples associated with heavy alcohol use
Kärkkäinen, Olli; Kokla, Marietta; Lehtonen, Marko; Auriola, Seppo; Martiskainen, Mika; Tiihonen, Jari; Karhunen, Pekka J.; Hanhineva, Kati; Kok, Eloise. 2021. Addiction biology. 26: e13035 A1 Journal article (refereed), original research -
Effect of intravenous ghrelin administration, combined with alcohol, on circulating metabolome in heavy drinking individuals with alcohol use disorder
Kärkkäinen, Olli; Farokhnia, Mehdi; Klåvus, Anton; Auriola, Seppo; Lehtonen, Marko; Deschaine, Sara L.; Piacentino, Daria; Abshire, Kelly M.; Jackson, Shelley N.; Leggio, Lorenzo. 2021. Alcoholism-clinical and experimental research. 45: 2207-2216 A1 Journal article (refereed), original research -
Ganciclovir and Its Hemocompatible More Lipophilic Derivative Can Enhance the Apoptotic Effects of Methotrexate by Inhibiting Breast Cancer Resistance Protein (BCRP)
Markowicz-Piasecka, M; Huttunen, J; Montaser, A; Adla, SK; Auriola, S; Lehtonen, M; Huttunen, KM. 2021. International journal of molecular sciences. 22: 7727 A1 Journal article (refereed), original research -
PCOS Features and Steroid Profiles Among Young Adult Women with a History of Premature Adrenarche
Tennilä, Jussi; Jääskeläinen, Jarmo; Utriainen, Pauliina; Voutilainen, Raimo; Häkkinen, Merja; Auriola, Seppo; Morin-Papunen, Laure; Liimatta, Jani. 2021. Journal of clinical endocrinology and metabolism. 106: e3335-e3345 A1 Journal article (refereed), original research -
Partitioning and Spatial Distribution of Drugs in Ocular Surface Tissues
Balla, Anusha; Auriola, Seppo; Grey, Angus C; Demarais, Nicholas J; Valtari, Annika; Heikkinen, Emma M; Toropainen, Elisa; Urtti, Arto; Vellonen, Kati-Sisko; Ruponen, Marika. 2021. Pharmaceutics. 13: 658 A1 Journal article (refereed), original research -
Pharmacological inhibition of 17ß-hydroxysteroid dehydrogenase impairs human endometrial cancer growth in an orthotopic xenograft mouse model
Xanthoulea, Sofia; Konings, Gonda F.J.; Saarinen, Niina; Delvoux, Bert; Kooreman, Loes F.S.; Koskimies, Pasi; Häkkinen, Merja R.; Auriola, Seppo; D'Avanzo, Elisabetta; Walid, Youssef; Verhaegen, Frank; Lieuwes, Natasja G.; Caiment, Florian; Kruitwagen, Roy; ENITEC; Romano, Andrea. 2021. Cancer letters. 508: 18-29 A1 Journal article (refereed), original research -
Putative metabolites involved in the beneficial effects of wholegrain cereal: Nontargeted metabolite profiling approach
Vitale, Marilena; Hanhineva, Kati; Koistinen, Ville; Auriola, Seppo; Paananen, Jussi; Costabile, Giuseppina; Della Pepa, Giuseppe; Rivellese, Angela A.; Riccardi, Gabriele; Giacco, Rosalba. 2021. Nutrition metabolism and cardiovascular diseases. 31: 1156-1165 A1 Journal article (refereed), original research -
Systemic inflammation induced changes in protein expression of ABC transporters and ionotropic glutamate receptor subunit 1 in the cerebral cortex of familial Alzheimer`s disease mouse model
Puris, Elena; Auriola, Seppo; Korhonen, Paula; Loppi, Sanna; Kanninen, Katja M; Malm, Tarja; Koistinaho, Jari; Gynther, Mikko. 2021. Journal of pharmaceutical sciences. 110: 3953-3962 A1 Journal article (refereed), original research -
The Effect of Single Nucleotide Variations in the Transmembrane Domain of OATP1B1 on in vitro Functionality
Kiander, Wilma; Vellonen, Kati-Sisko; Malinen, Melina M.; Gynther, Mikko; Hagström, Marja; Bhattacharya, Madhushree; Auriola, Seppo; Koenderink, Jan B.; Kidron, Heidi. 2021. Pharmaceutical research. 38: 1663-1675 A1 Journal article (refereed), original research -
Caffeine content in newborn hair correlates with maternal dietary intake
Lehtonen, Anni; Uusitalo, Lauri; Auriola, Seppo; Backman, Katri; Heinonen, Seppo; Keski-Nisula, Leea; Pasanen, Markku; Pekkanen, Juha; Tuomainen, Tomi-Pekka; Voutilainen, Raimo; Hantunen, Sari; Lehtonen, Marko. 2020. European journal of nutrition. 2021; 60: 193-201 A1 Journal article (refereed), original research -
Cancer Alters the Metabolic Fingerprint of Extracellular Vesicles
Palviainen, Mari; Laukkanen, Kirsi; Tavukcuoglu, Zeynep; Velagapudi, Vidya; Kärkkäinen, Olli; Hanhineva, Kati; Auriola, Seppo; Ranki, Annamari; Siljander, Pia. 2020. Cancers. 12: 3292 A1 Journal article (refereed), original research -
Changes in circulating metabolome precede alcohol-related diseases in middle-aged men: a prospective population-based study with a 30-year follow-up
Kärkkäinen, Olli; Klåvus, Anton; Voutilainen, Ari; Virtanen, Jyrki; Lehtonen, Marko; Auriola, Seppo; Kauhanen, Jussi; Rysä, Jaana. 2020. Alcoholism-clinical and experimental research. 44: 2457-2467 A1 Journal article (refereed), original research -
Circulatory and prostatic tissue lipidomic profiles shifts after high-dose atorvastatin use in men with prostate cancer
Raittinen, Paavo; Niemistö, Kati; Pennanen, Erika; Syvälä, Heimo; Auriola, Seppo; Riikonen, Jarno; Lehtimäki, Terho; Ilmonen, Pauliina; Murtola, Teemu. 2020. Scientific reports. 10: 12016 A1 Journal article (refereed), original research -
L-Type Amino Acid Transporter 1 Enables the Efficient Brain Delivery of Small-Sized Prodrug across the Blood-Brain Barrier and into Human and Mouse Brain Parenchymal Cells
Montaser, Ahmed B; Järvinen, Juulia; Löffler, Susanne; Huttunen, Johanna; Auriola, Seppo; Lehtonen, Marko; Jalkanen, Aaro; Huttunen, Kristiina M. 2020. Acs chemical neuroscience. 11: 4301-4315 A1 Journal article (refereed), original research -
L-Type amino acid transporter 1 as a target for drug delivery
Puris, Elena; Gynther, Mikko; Auriola, Seppo; Huttunen, Kristiina. 2020. Pharmaceutical research. 37: 88 A2 Review article, Literature review, Systematic review -
Metabolome of canine and human saliva: a non-targeted metabolomics study
Turunen, Soile; Puurunen, Jenni; Auriola, Seppo; Kullaa, Arja M; Kärkkäinen, Olli; Lohi, Hannes; Hanhineva, Kati. 2020. Metabolomics. 16: 90 A1 Journal article (refereed), original research -
Plasma lipid profile associates with the improvement of psychological well-being in individuals with perceived stress symptoms
Noerman, S; Klåvus, A; Järvelä-Reijonen, E; Karhunen, L; Auriola, S; Korpela, R; Lappalainen, R; Kujala, UM; Puttonen, S; Kolehmainen, M; Hanhineva, K. 2020. Scientific reports. 10: 2143 A1 Journal article (refereed), original research -
Prodrug Approach for Posterior Eye Drug Delivery: Synthesis of Novel Ganciclovir Prodrugs and in Vitro Screening with Cassette Dosing
Heikkinen, Emma M; Ruponen, Marika; Jasper, Lisa-Marie; Leppänen, Jukka; Hellinen, Laura; Urtti, Arto; Auriola, Seppo; Rautio, Jarkko; Vellonen, Kati-Sisko. 2020. Molecular pharmaceutics. 17: 1945-1953 A1 Journal article (refereed), original research -
Release of functional dexamethasone by intracellular enzymes: A modular peptide-based strategy for ocular drug delivery
Bhattacharya, Madhushree; Sadeghi, Amir; Sarkhel, Sanjay; Hagström, Marja; Bahrpeyma, Sina; Toropainen, Elisa; Auriola, Seppo; Urtti, Arto. 2020. Journal of controlled release. 327: 584-594 A1 Journal article (refereed), original research -
Side-stream products of malting: a neglected source of phytochemicals
Koistinen, Ville M; Tuomainen, Marjo; Lehtinen, Pekka; Peltola, Petri; Auriola, Seppo; Jonsson, Karin; Hanhineva, Kati. 2020. npj science of food. 4: 21 A1 Journal article (refereed), original research -
Access and concentrations of atorvastatin in the prostate in men with prostate cancer
Knuuttila, Emma; Riikonen, Jarno; Syvälä, Heimo; Auriola, Seppo; Murtola, Teemu J. 2019. Prostate. 79: 1427-1434 A1 Journal article (refereed), original research -
Associations of IGF-1 and Adrenal Androgens with Cognition in Childhood
Mäntyselkä, A; Haapala, EA; Lindi, V; Häkkinen, MR; Auriola, S; Jääskeläinen, J; Lakka, TA. 2019. Hormone research in paediatrics. 91: 329-335 A1 Journal article (refereed), original research -
Contribution of gut microbiota to metabolism of dietary glycine betaine in mice and in vitro colonic fermentation
Koistinen, VM; Kärkkäinen, O; Borewicz, K; Zarei, I; Jokkala, J; Micard, V; Rosa-Sibakov, N; Auriola, S; Aura, AM; Smidt, H; Hanhineva, K. 2019. Microbiome. 7: 103 A1 Journal article (refereed), original research -
Distribution of Small Molecular Weight Drugs into the Porcine Lens: Studies on Imaging Mass Spectrometry, Partition Coefficients, and Implications in Ocular Pharmacokinetics
Heikkinen, EM; Auriola, S; Ranta, VP; Demarais, N; Grey, A; Del Amo, E; Toropainen, E; Vellonen, KS; Urtti, A; Ruponen, M. 2019. Molecular pharmaceutics. 16: 3968-3976 A1 Journal article (refereed), original research -
Gender and dose-related metabolome alterations in rat offspring after in utero and lactational exposure to PCB 180
Pikkarainen, A; Lehtonen, M; Håkansson, H; Auriola, S; Viluksela, M. 2019. Toxicology and applied pharmacology. 370: 56-64 A1 Journal article (refereed), original research -
L-Type Amino Acid Transporter 1 (LAT1/Lat1)-Utilizing Prodrugs Can Improve the Delivery of Drugs into Neurons, Astrocytes and Microglia
Huttunen J, Peltokangas S, Gynther M, Natunen T, Hiltunen M, Auriola S, Ruponen M, Vellonen KS, Huttunen KM. 2019. Scientific reports. 9: 12860 A1 Journal article (refereed), original research -
L-type amino acid transporter 1 utilizing prodrugs of ferulic acid revealed structural features supporting the design of prodrugs for brain delivery
Puris, E; Gynther, M; Huttunen, J; Auriola, S; Huttunen, KM. 2019. European journal of pharmaceutical sciences. 129: 99-109 A1 Journal article (refereed), original research -
Mechanistic Study on the Use of the l-Type Amino Acid Transporter 1 for Brain Intracellular Delivery of Ketoprofen via Prodrug: A Novel Approach Supporting the Development of Prodrugs for Intracellular Targets
Puris, Elena; Gynther, Mikko; de Lange, Elizabeth C M; Auriola, Seppo; Harnmarlund-Udenaes, Margareta; Huttunen, Kristiina M; Loryan, Irena. 2019. Molecular pharmaceutics. 16: 3261-3274 A1 Journal article (refereed), original research -
Metabolic signature of extracellular vesicles depends on the cell culture conditions
Palviainen, Mari; Saari, Heikki; Kärkkäinen, Olli; Pekkinen, Jenna; Auriola, Seppo; Yliperttula, Marjo; Puhka, Maija; Hanhineva, Kati; Siljander, Pia R-M. 2019. Journal of extracellular vesicles. 8: 1596669 A1 Journal article (refereed), original research -
Metabolism of Scoparone in Experimental Animals and Humans
Juvonen, RO; Novák, F; Emmanouilidou, E; Auriola, S; Timonen, J; Heikkinen, AT; Küblbeck, J; Finel, M; Raunio, H. 2019. Planta medica. 85: 453-464 A1 Journal article (refereed), original research -
Quantitative assessment of betainized compounds and associations with dietary and metabolic biomarkers in the randomized study of the healthy Nordic diet (SYSDIET)
Tuomainen, M; Kärkkäinen, O; Leppänen, J; Auriola, S; Lehtonen, M; Savolainen, MJ; Hermansen, K; Risérus, U; Åkesson, B; Thorsdottir, I; Kolehmainen, M; Uusitupa, M; Poutanen, K; Schwab, U; Hanhineva, K. 2019. American journal of clinical nutrition. 110: 1108-1118 A1 Journal article (refereed), original research -
A Non-Targeted LC-MS Profiling Reveals Elevated Levels of Carnitine Precursors and Trimethylated Compounds in the Cord Plasma of Pre-Eclamptic Infants
Jääskeläinen, Tiina; Kärkkäinen, Olli; Jokkala, Jenna; Litonius, Kaisa; Heinonen, Seppo; Auriola, Seppo; Lehtonen, Marko; Hanhineva, Kati; Laivuori, Hannele; FINNPEC. 2018. Scientific reports. 8: 14616 A1 Journal article (refereed), original research -
Alcohol and substance use are associated with altered metabolome in the first trimester serum samples of pregnant mothers
Lehikoinen, Anni I; Kärkkäinen, Olli K; Lehtonen, Marko AS; Auriola, Seppo OK; Hanhineva, Kati J; Heinonen, Seppo T. 2018. European journal of obstetrics and gynecology and reproductive biology. 223: 79-84 A1 Journal article (refereed), original research -
Alzheimer's Disease Phenotype or Inflammatory Insult Does Not Alter Function of L-Type Amino Acid Transporter 1 in Mouse Blood-Brain Barrier and Primary Astrocytes
Gynther, Mikko; Puris, Elena; Peltokangas, Soile; Auriola, Seppo; Kanninen, Katja M; Koistinaho, Jari; Huttunen, Kristiina M; Ruponen, Marika; Vellonen, Kati-Sisko. 2018. Pharmaceutical research. 2019; 36: 17 A1 Journal article (refereed), original research -
Analysis by LC-MS/MS of endogenous steroids from human serum, plasma, endometrium and endometriotic tissue
Häkkinen, MR; Heinosalo, T; Saarinen, N; Linnanen, T; Voutilainen, R; Lakka, T; Jääskeläinen, J; Poutanen, M; Auriola, S. 2018. Journal of pharmaceutical and biomedical analysis. 152: 165-172 A1 Journal article (refereed), original research -
Associations of serum indolepropionic acid, a gut microbiota metabolite, with type 2 diabetes and low-grade inflammation in high-risk individuals
Tuomainen, Marjo; Lindström, Jaana; Lehtonen, Marko; Auriola, Seppo; Pihlajamäki, Jussi; Peltonen, Markku; Tuomilehto, Jaakko; Uusitupa, Matti; de Mello, Vanessa D; Hanhineva, Kati. 2018. Nutrition and diabetes. 8: 35 A1 Journal article (refereed), original research -
Blood steroids are associated with prognosis and fat distribution in endometrial cancer
Tangen, IL; Fasmer, KE; Konings, GF; Jochems, A; Delvoux, B; Xanthoulea, S; Stokowy, T; Strand, E; Berg, HF; Auriola, S; Trovik, J; Häkkinen, MR; Haldorsen, IS. 2018. Gynecologic oncology. 2019; 152: 46-52 A1 Journal article (refereed), original research -
Development of an Image-Guided Orthotopic Xenograft Mouse Model of Endometrial Cancer with Controllable Estrogen Exposure
Konings, GF; Saarinen, N; Delvoux, B; Kooreman, L; Koskimies, P; Krakstad, C; Fasmer, KE; Haldorsen, IS; Zaffagnini, A; Häkkinen, MR; Auriola, S; Dubois, L; Lieuwes, N; Verhaegen, F; Schyns, LE; Kruitwagen, RF; Xanthoulea, S; Romano, A. 2018. International journal of molecular sciences. 19: 2547 A1 Journal article (refereed), original research -
Diets rich in whole grains increase betainized compounds associated with glucose metabolism
Kärkkäinen, O; Lankinen, MA; Vitale, M; Jokkala, J; Leppänen, J; Koistinen, V; Lehtonen, M; Giacco, R; Rosa-Sibakov, N; Micard, V; Rivellese, AAA; Schwab, U; Mykkänen, H; Uusitupa, M; Kolehmainen, M; Riccardi, G; Poutanen, K; Auriola, S; Hanhineva, K. 2018. American journal of clinical nutrition. 108: 971-979 A1 Journal article (refereed), original research -
Discovery of Polar Spirocyclic Orally Bioavailable Urea Inhibitors of Soluble Epoxide Hydrolase
Lukin, Alexey; Kramer, Jan; Hartmann, Markus; Weizel, Lilia; Hernandez- Olmos, Victor; Falahati, Konstantin; Burghardt, Irene; Kalinchenkova, Natalia; Bagnyukova, Darya; Zhurilo, Nikolay; Rautio, Jarkko; Forsberg, Markus; Ihalainen, Jouni; Auriola, Seppo; Leppänen, Jukka; Konstantinov, Igor; Pogoryelov, Denys; Proschak, Ewgenij; Dar'in, Dmitry; Krasavin, Mikhail. 2018. Bioorganic chemistry. 80: 655-667 A1 Journal article (refereed), original research -
HX600, a synthetic agonist for RXR-Nurr1 heterodimer complex, prevents ischemia-induced neuronal damage
Loppi, S; Kolosowska, N; Kärkkäinen, O; Korhonen, P; Huuskonen, M; Grubman, A; Dhungana, H; Wojciechowski, S; Pomeshchik, Y; Giordano, M; Kagechika, H; White, A; Auriola, S; Koistinaho, J; Landreth, G; Hanhineva, K; Kanninen, K; Malm, T. 2018. Brain behavior and immunity. 73: 670-681 A1 Journal article (refereed), original research -
High-Fat Diet, Betaine, and Polydextrose Induce Changes in Adipose Tissue Inflammation and Metabolism in C57BL/6J Mice
Airaksinen, Kaisa; Jokkala, Jenna; Ahonen, Ilmari; Auriola, Seppo; Kolehmainen, Marjukka; Hanhineva, Kati; Tiihonen, Kirsti. 2018. Molecular nutrition and food research. 62: 1800455 A1 Journal article (refereed), original research -
Plasma metabolites associated with type 2 diabetes in a Swedish population: a case-control study nested in a prospective cohort
Shi, L; Brunius, C; Lehtonen, M; Auriola, S; Bergdahl, IA; Rolandsson, O; Hanhineva, K; Landberg, R. 2018. Diabetologia. 61: 849-861 A1 Journal article (refereed), original research -
Simultaneous analysis by LC-MS/MS of 22 ketosteroids with hydroxylamine derivatization and underivatized estradiol from human plasma, serum and prostate tissue
Häkkinen, Merja R; Murtola, Teemu; Voutilainen, Raimo; Poutanen, Matti; Linnanen, Tero; Koskivuori, Johanna; Lakka, Timo; Jääskeläinen, Jarmo; Auriola, Seppo. 2018. Journal of pharmaceutical and biomedical analysis. 2019; 164: 642-652 A1 Journal article (refereed), original research -
Structural properties for selective and efficient L-type amino acid transporter 1 (LAT1) mediated cellular uptake
Kärkkäinen, J; Gynther, M; Kokkola, T; Petsalo, A; Auriola, S; Lahtela-Kakkonen, M; Laine, K; Rautio, J; Huttunen, KM. 2018. International journal of pharmaceutics. 544: 91-99 A1 Journal article (refereed), original research -
Transplacental Transfer and Metabolism of Diuron in Human Placenta
Mohammed, Ali Mustafa; Karttunen, Vesa; Huuskonen, Pasi; Huovinen, Marjo; Auriola, Seppo; Vähäkangas, Kirsi. 2018. Toxicology letters. 295: 307-313 A1 Journal article (refereed), original research -
Whole grain intake associated molecule 5-aminovaleric acid betaine decreases ß-oxidation of fatty acids in mouse cardiomyocytes
Kärkkäinen, Olli; Tuomainen, Tomi; Koistinen, Ville; Tuomainen, Marjo; Leppänen, Jukka; Laitinen, Tuomo; Lehtonen, Marko; Rysä, Jaana; Auriola, Seppo; Poso, Antti; Tavi, Pasi; Hanhineva, Kati. 2018. Scientific reports. 8: 13036 A1 Journal article (refereed), original research -
Antiandrogens Reduce Intratumoral Androgen Concentrations and Induce Androgen Receptor Expression in Castration-Resistant Prostate Cancer Xenografts
Knuuttila M, Mehmood A, Huhtaniemi R, Yatkin E, Häkkinen MR, Oksala R, Laajala TD, Ryberg H, Handelsman DJ, Aittokallio T, Auriola S, Ohlsson C, Laiho A, Elo LL, Sipilä P, Mäkelä SI, Poutanen M. 2017. American journal of pathology. 2018; 188: 216-228 A1 Journal article (refereed), original research -
Augmentation of Anticancer Drug Efficacy in Murine Hepatocellular Carcinoma Cells by a Peripherally Acting Competitive N-Methyl-d-aspartate (NMDA) Receptor Antagonist
Gynther M, Proietti Silvestri I, Hansen JC, Hansen KB, Malm T, Ishchenko Y, Larsen Y, Han L, Kayser S, Auriola S, Petsalo A, Nielsen B, Pickering DS, Bunch L. 2017. Journal of medicinal chemistry. 60: 9885-9904 A1 Journal article (refereed), original research -
Comparison of In Vitro Hepatic Scoparone 7-O-Demethylation between Humans and Experimental Animals
Fayyaz A, Makwinja S, Auriola S, Raunio H, Juvonen R. 2017. Planta medica. 2018; 84: 320-328 A1 Journal article (refereed), original research -
Differentially cleaving peptides as a strategy for controlled drug release in human retinal pigment epithelial cells
Bhattacharya M, Sarkhel S, Peltoniemi J, Broadbridge R, Tuomainen M, Auriola S, Urtti A. 2017. Journal of controlled release. 251: 37-48 A1 Journal article (refereed), original research -
Impact of Chemical Structure on Conjunctival Drug Permeability: Adopting Porcine Conjunctiva and Cassette Dosing for Construction of In Silico Model
Ramsay E, Ruponen M, Picardat T, Tengvall U, Tuomainen M, Auriola S, Toropainen E, Urtti A, del Amo EM. 2017. Journal of pharmaceutical sciences. 106: 2463-2471 A1 Journal article (refereed), original research -
Indolepropionic acid and novel lipid metabolites are associated with a lower risk of type 2 diabetes in the Finnish Diabetes Prevention Study
de Mello VD, Paananen J, Lindstrom J, Lankinen MA, Shi L, Kuusisto J, Pihlajamaki J, Auriola S, Lehtonen M, Rolandsson O, Bergdahl IA, Nordin E, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Landberg R, Eriksson JG, Tuomilehto J, Hanhineva K, Uusitupa M. 2017. Scientific reports. 7: 46337 A1 Journal article (refereed), original research -
Inner Blood-Retinal Barrier Dominantly Expresses Breast Cancer Resistance Protein: Comparative Quantitative Targeted Absolute Proteomics Study of CNS Barriers in Pig
Zhang Z, Uchida Y, Hirano S, Ando D, Kubo Y, Auriola S, Akanuma S-I, Hosoya K-I, Urtti A, Terasaki T, Tachikawa M. 2017. Molecular pharmaceutics. 14: 3729-3738 A1 Journal article (refereed), original research -
Butyrophilin 3A/CD277-Dependent Activation of Human gamma delta T Cells: Accessory Cell Capacity of Distinct Leukocyte Populations
Nerdal Patrik T, Peters Christian, Oberg Hans-Heinrich, Zlatev Hristo, Lettau Marcus, Quabius Elgar S, Sousa Sofia, Gonnermann Daniel, Auriola Seppo, Olive Daniel, Määttä Jorma, Janssen Ottmar, Kabelitz Dieter. 2016. Journal of immunology. 197: 3059-3068 A1 Journal article (refereed), original research -
Increased steroid hormone dehydroepiandrosterone and pregnenolone levels in post-mortem brain samples of alcoholics
Kärkkäinen Olli, Häkkinen Merja R, Auriola Seppo, Kautiainen Hannu, Tiihonen Jari, Storvik Markus. 2016. Alcohol. 52: 63-70 A1 Journal article (refereed), original research -
Intracellular PK/PD Relationships of Free and Liposomal Doxorubicin: Quantitative Analyses and PK/PD Modeling
Soininen Suvi K, Vellonen Kati-Sisko, Heikkinen Aki T, Auriola Seppo, Ranta Veli-Pekka, Urtti Arto, Ruponen Marika. 2016. Molecular pharmaceutics. 13: 1358-1365 A1 Journal article (refereed), original research -
Uptake of free, calcium-bound and liposomal encapsulated nitrogen containing bisphosphonates by breast cancer cells
Zlatev Hristo P, Auriola Seppo, Mönkkönen Jukka, Määttä Jorma A. 2016. European journal of pharmaceutical sciences. 86: 58-66 A1 Journal article (refereed), original research -
CMPF Does Not Associate with Impaired Glucose Metabolism in Individuals with Features of Metabolic Syndrome
Lankinen Maria A., Hanhineva Kati, Kolehmainen Marjukka, Lehtonen Marko, Auriola Seppo, Mykkänen Hannu, Poutanen Kaisa, Schwab Ursula, Uusitupa Matti. 2015. PLoS ONE. 10: e0124379 A1 Journal article (refereed), original research -
Comparison of trapping profiles between d-peptides and glutathione in the identification of reactive metabolites
Laine Jaana E, Häkkinen Merja R, Auriola Seppo, Juvonen Risto O, Pasanen Markku. 2015. Toxicology reports. 2: 1024-1032 A1 Journal article (refereed), original research -
Discovery of urinary biomarkers of whole grain rye intake in free-living subjects using non-targeted LC-MS metabolite profiling
Hanhineva Kati, Brunius Carl, Andersson Agneta, Marklund Matti, Juvonen Risto, Keski-Rahkonen Pekka, Auriola Seppo, Landberg Rikard. 2015. Molecular nutrition and food research. [epub ahead of print 10 SEP 2015]: - A1 Journal article (refereed), original research -
Human placental cell and tissue uptake of doxorubicin and its liposomal formulations
Soininen Suvi K, Repo Jenni K, Karttunen Vesa, Auriola Seppo, Vähäkangas Kirsi H, Ruponen Marika. 2015. Toxicology letters. 239: 108-114 A1 Journal article (refereed), original research -
Inhibitory effects and oxidation of 6-methylcoumarin, 7-methylcoumarin and 7-formylcoumarin via human CYP2A6 and its mouse and pig orthologous enzymes
Juvonen Risto O, Kuusisto Mira, Fohrgrup Carolin, Pitkänen Mari H, Nevalainen Tapio J, Auriola Seppo, Raunio Hannu, Pasanen Markku, Pentikäinen Olli T. 2015. Xenobiotica. 2016; 46: 14-24 A1 Journal article (refereed), original research -
Liposome encapsulated zoledronate favours M1-like behaviour in murine macrophages cultured with soluble factors from breast cancer cells
Sousa Sofia, Auriola Seppo, Mönkkönen Jukka, Määttä Jorma. 2015. Bmc cancer. 15: 1-11 A1 Journal article (refereed), original research -
Zearalenone metabolism in human placental subcellular organelles, JEG-3 cells, and recombinant CYP19A1
Huuskonen Pasi, Auriola Seppo, Pasanen Markku. 2015. Placenta. 36: 1052-1055 A1 Journal article (refereed), original research -
Bisphosphonate research
Määttä Jorma, Mönkkönen Jukka, Auriola Seppo, Sousa Sofia, Zlatev Hristo, Arkko Satu. 2014. Dosis. 30: 199 B1 Non-refereed journal articles -
Castration Induces Up-Regulation of Intratumoral Androgen Biosynthesis and Androgen Receptor Expression in an Orthotopic VCaP Human Prostate Cancer Xenograft Model
Knuuttila Matias, Yatkin Emrah, Kallio Jenny, Savolainen Saija, Laajala Teemu D, Aittokallio Tero, Oksala Riikka, Häkkinen Merja, Keski-Rahkonen Pekka, Auriola Seppo, Poutanen Matti, Mäkelä Sari. 2014. American journal of pathology. 184: 2163-2173 A1 Journal article (refereed), original research -
Human testicular peritubular cells host putative stem Leydig cells with steroidogenic capacity
Landreh Luise, Spinnler Katrin, Schubert Kerstin, Häkkinen Merja R, Auriola Seppo, Poutanen Matti, Söder Olle, Svechnikov Konstantin, Mayerhofer Artur. 2014. Journal of clinical endocrinology and metabolism. 99: E1227-E1235 A1 Journal article (refereed), original research -
Identification of a New Reactive Metabolite of Pyrrolizidine Alkaloid Retrorsine: (3H-Pyrrolizin-7-yl)methanol
Fashe Muluneh M, Juvonen Risto O, Petsalo Aleksanteri, Rahnasto-Rilla Minna, Auriola Seppo, Soininen Pasi, Vepsäläinen Jouko, Pasanen Markku. 2014. Chemical research in toxicology. 27: 1950-1957 A1 Journal article (refereed), original research -
Intra-tissue steroid profiling indicates differential progesterone and testosterone metabolism in the endometrium and endometriosis lesions
Huhtinen Kaisa, Saloniemi-Heinonen Taija, Keski-Rahkonen Pekka, Desai Reena, Laajala Daniel, Ståhle Mia, Häkkinen Merja R, Awosanya Michael, Suvitie Pia, Kujari Harry, Aittokallio Tero, Handelsman David J, Auriola Seppo, Perheentupa Antti, Poutanen Matti. 2014. Journal of clinical endocrinology and metabolism. 99: E2188-E2197 A1 Journal article (refereed), original research -
Metabolite profiling of leek (Allium porrum L) cultivars by (1) H NMR and HPLC-MS
Soininen Tuula H, Jukarainen Niko, Soininen Pasi, Auriola Seppo O, Julkunen-Tiitto Riitta, Oleszek Wieslaw, Stochmal Anna, Karjalainen Reijo O, Vepsäläinen Jouko J. 2014. Phytochemical analysis. 25: 220-228 A1 Journal article (refereed), original research -
Probenecid as a sensitizer of bisphosphonate-mediated effects in breast cancer cells
Ebert Regina, Meissner-Weigl Jutta, Zeck Sabine, Määttä Jorma, Auriola Seppo, Coimbra de Sousa Sofia, Mentrup Birgit, Graser Stephanie, Rachner Tilman D, Hofbauer Lorenz C, Jakob Franz. 2014. Molecular cancer. 13: 265 A1 Journal article (refereed), original research -
Quantitative Evaluation of Intracellular Distribution and Human Placental Transfer of Doxorubicin and its Liposomal Formulations
Soininen Suvi K, Repo Jenni K, Karttunen Vesa, Koivisto Heta, Auriola Seppo, Vähäkangas Kirsi H, Ruponen Marika. 2014. - -
Quantitative metabolite profiling of edible onion species by NMR and HPLC-MS
Soininen Tuula H, Jukarainen Niko, Auriola Seppo O, Julkunen-Tiitto Riitta, Karjalainen Reijo, Vepsäläinen Jouko J. 2014. Food chemistry. 165: 499-505 A1 Journal article (refereed), original research -
Reactive Metabolites in Early Drug Development: Predictive in Vitro Tools
Pelkonen Olavi, Pasanen Markku, Tolonen Ari, Koskinen Mikko, Hakkola Jukka, Abass Khaled, Laine Jaana, Häkkinen Merja, Juvonen Risto, Auriola Seppo, Storvik Markus, Huuskonen Pasi, Rousu Timo, Rahikkala Maiju. 2014. Current medicinal chemistry. 2015; 22: 538-550 A2 Review article, Literature review, Systematic review -
Analysis of free, mono- and diacetylated polyamines from human urine by LC-MS/MS
Häkkinen Merja R, Roine Antti, Auriola Seppo, Tuokko Antti, Veskimäe Erik, Keinänen Tuomo A, Lehtimäki Terho, Oksala Niku, Vepsäläinen Jouko. 2013. Journal of chromatography b: analytical technologies in the biomedical and life sciences. 941: 81-89 A1 Journal article (refereed), original research -
Betaine supplementation causes increase in carnitine metabolites in the muscle and liver of mice fed a high-fat diet as studied by nontargeted LC-MS metabolomics approach
Pekkinen Jenna, Olli Kaisa, Huotari Anne, Tiihonen Kirsti, Keski-Rahkonen Pekka, Lehtonen Marko, Auriola Seppo, Kolehmainen Marjukka, Mykkänen Hannu, Poutanen Kaisa, Hanhineva Kati. 2013. Molecular nutrition and food research. 57: 1959-1968 A1 Journal article (refereed), original research -
Interactions of sesquiterpenes zederone and germacrone with the human cytochrome P450 system
Pimkaew Prapapan, Küblbeck Jenni, Petsalo Aleksanteri, Jukka Jouni, Suksamrarn Apichart, Juvonen Risto, Auriola Seppo, Piyachaturawat Pawinee, Honkakoski Paavo. 2013. Toxicology in vitro. 27: 2005-2012 A1 Journal article (refereed), original research -
LC-MS analysis of estradiol in human serum and endometrial tissue: Comparison of electrospray ionization, atmospheric pressure chemical ionization and atmospheric pressure photoionization
Keski-Rahkonen Pekka, Huhtinen Kaisa, Desai Reena, Harwood D. Tim, Handelsman David J, Poutanen Matti, Auriola Seppo. 2013. Journal of mass spectrometry. 48: 1050-1058 A1 Journal article (refereed), original research -
Peptides conjugated to antisense interleukin-6 by click chemistry
Wang Chang-Fang, Auriola Seppo, Hirvonen Jouni, Santos Hélder A. 2013. Current medicinal chemistry. 2014:21: 1247-1254 A1 Journal article (refereed), original research -
Acute effects of ethanol on transplacental transfer
Karttunen Vesa, Veid Jenni, Myöhänen Kirsi, Myllynen Päivi, Auriola Seppo, Halonen Toivo, Vähäkangas Kirsi. 2012. Toxicology letters -
Aflatoxin B1 up-regulates CYP19A1 in JEG-3 cells
Huuskonen Pasi, Storvik Markus, Kyllönen Taija, Lehtonen Sarka, El-Nezami Hani, Auriola Seppo, Pasanen Markku. 2012. - -
Comparison of Electrochemical and Biological Oxidation of Pyrrolizidine Alkaloid Retrorsine
Fashe Muluneh, Petsalo Aleksanteri, Juvonen Risto O, Rahnasto-Rilla Minna, Pasanen Markku, Auriola Seppo. 2012. Dosis -
Comparison of liquid chromatography-microchip/mass spectrometry to conventional liquid chromatography-mass spectrometry for the analysis of steroids
Ahonen Linda, Keski-Rahkonen Pekka, Saarelainen Taija, Paviala Jenni, Ketola Raimo A, Auriola Seppo, Poutanen Matti, Kostiainen Risto. 2012. Analytica chimica acta. 721: 115-121 A1 Journal article (refereed), original research -
Human Placental Perfusions of Anticancer Drug Doxorubicin and Liposomes Encapsulated with Doxorubicin
Repo Jenni, Soininen Suvi K, Meftah Azin, Auriola Seppo, Ruponen Marika, Vähäkangas Kirsi. 2012. Dosis -
Intratumor Androgen Biosynthesis in VCaP Xenografts - A model for Castration-Resistant Prostate Cancer
Knuuttila Matias, Yatkin E, Kallio J, Savolainen S, Auriola Seppo, Poutanen M, Mäkelä S. 2012. Dosis -
Polyamine flux analysis by determination of heavy isotope incorporation from 13C, 15N-enriched amino acids into polyamines by LC-MS/MS
Cerrada-Gimenez Marc, Häkkinen Merja R, Vepsäläinen Jouko, Auriola Seppo, Alhonen Leena, Keinänen Tuomo A. 2012. Amino acids. 42: 451-460 A1 Journal article (refereed), original research -
Transplacental transfer of melamine
Partanen Heidi, Vähäkangas Kirsi, Woo Chit SJ, Auriola Seppo, Veid Jenni, Chen Y, Myllynen Päivi, El Nezami Hani. 2012. Placenta. 33: 60-66 A1 Journal article (refereed), original research -
2'-Deoxyguanosine as a surrogate trapping agent for DNA reactive drug metabolites
Häkkinen Merja R, Laine Jaana E, Juvonen Risto O, Auriola Seppo, Häyrinen Jukka, Pasanen Markku. 2011. Toxicology letters. 207: 34-41 A1 Journal article (refereed), original research -
Acute effects of ethanol on the transfer of nicotine and two dietary carcinogens in human placental perfusion
Veid Jenni, Karttunen Vesa, Myöhänen Kirsi, Myllynen Päivi, Auriola Seppo, Halonen Toivo, Vähäkangas Kirsi. 2011. Toxicology letters. 205: 257-264 A1 Journal article (refereed), original research -
Aflatoxin B1 - a potential endocrine disruptor - up-regulates CYP19A1 in JEG-3 cells
Storvik Markus, Huuskonen Pasi, Kyllönen Taija, Lehtonen Sarka, El-Nezami Hani, Auriola Seppo, Pasanen Markku. 2011. Toxicology letters. 202: 161 - 167 A1 Journal article (refereed), original research -
Correlation between time-dependent inhibition of human farnesyl pyrophosphate synthase and blockade of mevalonate pathway by nitrogen-containing bisphosphonates in cultured cells
Räikkönen Johanna, Taskinen Markku, Dunford James E, Mönkkönen Hannu, Auriola Seppo, Mönkkönen Jukka. 2011. Biochemical and biophysical research communications. 407: 663-667 A1 Journal article (refereed), original research -
Determination of endocannabinoids in nematodes and human brain tissue by liquid chromatography electrospray ionization tandem mass spectrometry
Lehtonen Marko, Storvik Markus, Malinen Hanna, Hyytiä Petri, Lakso Merja, Auriola Seppo, Wong Garry, Callaway James. 2011. Journal of chromatography b: analytical technologies in the biomedical and life sciences. 879: 677 - 694 A1 Journal article (refereed), original research -
Fast and sensitive liquid chromatography-mass spectometry assay for seven androgenic and progestagenic steroids in human serum
Keski-Rahkonen Pekka, Huhtinen Kaisa, Poutanen Matti, Auriola Seppo. 2011. Journal of steroid biochemistry and molecular biology. 127: 396-404 A1 Journal article (refereed), original research -
Immobilization of protein-coated drug nanoparticles in nanofibrillar cellulose matrices - Enhanced stability and release
Valo Hanna, Kovalainen Miia, Laaksonen Päivi, Häkkinen Merja, Auriola Seppo, Peltonen Leena, Linder Markus, Järvinen Kristiina, Hirvonen Jouni, Laaksonen Timo. 2011. Journal of controlled release. 156: 390-397 A1 Journal article (refereed), original research -
Simple, direct, and informative method for the assessment of CYP2C19 enzyme inactivation kinetics
Salminen Kaisa A, Leppänen Jukka, Venäläinen Jarkko I, Pasanen Markku, Auriola Seppo, Juvonen Risto O, Raunio Hannu. 2011. Drug metabolism and disposition. 39: 412 - 418 A1 Journal article (refereed), original research -
d-Isomer of gly-tyr-pro-cys-pro-his-pro peptide: A novel and sensitive in vitro trapping agent to detect reactive metabolites by electrospray mass spectrometry
Laine Jaana, Auriola Seppo, Pasanen Markku, Juvonen Risto. 2011. Toxicology in vitro. 25: 411 - 425 A1 Journal article (refereed), original research -
Anthocyanin variation in Finnish northern crowberry (Empetrum nigrum sp. hermaphroditum) populations
Koskela Ali, Anttonen Mikko, Soininen Tuula, Auriola Seppo, Julkunen-Tiitto Riitta, Karjalainen Reijo. 2010. -
Assessment of bisphosphonate activity in vitro
Mitrofan LM, Auriola S, Mönkkönen H & Mönkkönen J. 2010. Current pharmaceutical design. 16: 2970-2980 A2 Review article, Literature review, Systematic review -
Degradation of coeliac disease-inducing rye secalin by germinating cereal enzymes: diminishing toxic effects in intestinal epithelial cells
Stenman SM, Lindfors K, Venäläinen JI, Hautala A, Männistö PT, Garcia-Horsman JA, Kaukovirta-Norja A, Auriola S, Mauriala T, Mäki M et al. 2010. Clinical and experimental immunology. 161: 242-249 A1 Journal article (refereed), original research -
Genetic and environmental influence on maize kernel proteome
Anttonen MJ, Lehesranta S, Auriola S, Röhlig RM, Engel K-H & Kärenlampi SO. 2010. Journal of proteome research. 9: 6160-6168 A1 Journal article (refereed), original research -
Metabolism of N-alkylated spermine analogues by polyamine and spermine oxidases
Häkkinen M, Hyvönen MT, Auriola S, Casero RA Jr., Vepsäläinen J, Khomutov A, Alhonen L & Keinänen T. 2010. Amino acids. 38: 369-381 A1 Journal article (refereed), original research -
Mevalonate pathway intermediates downregulate zoledronic acid-induced isopentenyl pyrophosphate and ATP analog formation in human breast cancer cells
Räikkönen J, Mönkkönen H, Auriola S & Mönkkönen J. 2010. Biochemical pharmacology. 79: 777 - 783 A1 Journal article (refereed), original research -
Proteomic study of zinc accumulation and tolerance in metal hyperaccumulator plant Thlaspi caerulescens
Tuomainen M, Tervahauta A, Häyrinen J, Hassinen V, Schat H, Koistinen KM, Lehesranta S, Rantalainen K, Auriola S, Anttonen M & Kärenlampi S. 2010. -
Proteomics of Thlaspi caerulescens accessions and an inter-accession cross segregating for zinc accumulation
Tuomainen M, Tervahauta A, Hassinen V, Schat H, Koistinen KM, Lehesranta S, Rantalainen K, Häyrinen J, Auriola S, Anttonen M & Kärenlampi S. 2010. Journal of experimental botany. 61: 1075-1087 A1 Journal article (refereed), original research -
Proteomics of Thlaspi caerulescens accessions and inter-accession cross segregating for zinc accumulation
Tuomainen M, Tervahauta A, Häyrinen J, Hassinen V, Schat H, Koistinen K, Lehesranta S, Rantalainen K, Auriola S, Anttonen M & Kärenlampi S. 2010. -
Variation in the anthocyanin concentration of wild populations of crowberry (Empetrum nigrum L subsp. Hermaphroditum).
Koskela, A., Anttonen, M., Soininen, T., Saviranta, N., Auriola, S., Julkunen-Tiitto, R. and Karjalainen, R.. 2010. Journal of agricultural and food chemistry. 58: 12289-12295 A1 Journal article (refereed), original research -
Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes
Laine JE, Auriola S, Pasanen M, Juvonen RO. 2009. Xenobiotica. 39: 11-21 A1 Journal article (refereed), original research -
Analysis of endogenous ATP analogs and mevalonate pathway metabolites in cancer cell cultures using liquid chromatography-electrospray ionization mass spectrometry
Jauhiainen M, Mönkkönen H, Räikkönen J, Mönkkönen J, Auriola S. 2009. Journal of chromatography b: analytical technologies in the biomedical and life sciences. 877: 2967-2975 A1 Journal article (refereed), original research -
Atmospheric pressure thermospray ionization using a heated microchip nebulizer
Keski-Rahkonen P, Haapala M, Saarela V, Franssila S, Kotiaho T, Kostiainen R, Auriola S. 2009. Rapid communications in mass spectrometry. 23: 3313-3322 A1 Journal article (refereed), original research -
Cyclodextrins and chitosan derivatives in sublingual delivery of low solubility peptides: A study using cyclosporin A, alpha-cyclodextrin and quaternary chitosan N-betainate
Mannila J, Järvinen K, Holappa J, Matilainen L, Auriola S, Jarho P. 2009. International journal of pharmaceutics. 381: 19-24 A1 Journal article (refereed), original research -
Enzymatic detoxification of gluten by germinating wheat proteases: Implications for new treatment of celiac disease
Stenman SM, Venäläinen JI, Lindfors K, Auriola S, Mauriala T, Kaukovirta-Norja A, Jantunen A, Laurila K, Qiao S-W, Sollid LM, Männistö PT, Kaukinen K, Mäki M. 2009. Annals of medicine. 41: 390-400 A1 Journal article (refereed), original research -
Glucosamine sulphate does not increase extracellular matrix production at low oxygen tension
Qu C-J, Pöytäkangas T, Jauhiainen M, Auriola S, Lammi MJ. 2009. Cell and tissue research. 337: 103-111 A1 Journal article (refereed), original research -
Synthesis of novel deuterium labelled derivates of N-alkylated polyamines
Häkkinen MR, Keinänen TA, Khomutov AR, Auriola S, Weisell J, Alhonen L, Jänne J, Vepsäläinen J. 2009. Tetrahedron. 65: 547-562 A1 Journal article (refereed), original research -
The stability and dissolution properties of solid glucagon/gamma-cyclodextrin powder
Matilainen L, Maunu SL, Pajander J, Auriola S, Jääskeläinen I, Lambertsen Larsen K, Järvinen T, Jarho P. 2009. European journal of pharmaceutical sciences. 36: 412-420 A1 Journal article (refereed), original research -
Zoledronic acid induces formation of a pro-apoptotic ATP analogue and isopentenyl pyrophosphate in osteoclasts in vivo and in MCF-7 cells in vitro
Räikkönen J, Crockett JC, Rogers MJ, Mönkkönen H, Auriola S, Mönkkönen J. 2009. British journal of pharmacology. 157: 427-435 A1 Journal article (refereed), original research -
Animal-derived lipocalin allergens exhibit immunoglobulin E cross-reactivity
Saarelainen S, Rytkönen-Nissinen M, Rouvinen J, Taivainen A, Auriola S, Kauppinen A, Kinnunen T, Virtanen T. 2008. Clinical and experimental allergy. 38: 374-381 A1 Journal article (refereed), original research -
Bisphosphonate-induced ATP analog formation and its effect on inhibition of cancer cell growth
Mönkkönen H, Kuokkanen J, Holen I, Evans A, Lefley DV, Jauhiainen M, Auriola S, Mönkkönen J. 2008. Anti-cancer drugs. 19: 391-399 A1 Journal article (refereed), original research -
Characterization and fate of black currant and bilberry flavonols in enzyme-aided processing
Koponen JM, Happonen AM, Auriola S, Kontkanen H, Buchert J, Poutanen KS, Törrönen R, Koponen JM, Happonen AM, Poutanen KS, Törrönen R. 2008. Journal of agricultural and food chemistry. 56: 3136-3144 A1 Journal article (refereed), original research -
Downregulation of PPARs and SREBP by acyl-CoA-binding protein overexpression in transgenic rats
Oikari S, Ahtialansaari T, Heinonen MV, Mauriala T, Auriola S, Kiehne K, Fölsch UR, Jänne J, Alhonen L, Herzig KH. 2008. Pflugers archiv: european journal of physiology. 456: 369-377 A1 Journal article (refereed), original research -
High-performance liquid chromatography/electrospray ionization tandem mass spectrometry for characterization of enzymatic degradation of 2,2'-bis(2-oxazoline)-linked poly-epsilon-caprolactone
Pulkkinen M, Palmgrén JJ, Auriola S, Malin M, Seppälä J, Järvinen K. 2008. Rapid communications in mass spectrometry. 22: 121-129 A1 Journal article (refereed), original research -
Mannose inhibits hyaluronan synthesis by down-regulation of the cellular pool of UDP-N-acetylhexosamines
Jokela TA, Jauhiainen M, Auriola S, Kauhanen M, Tiihonen R, Tammi MI, Tammi RH. 2008. Journal of biological chemistry. 283: 7666-7673 A1 Journal article (refereed), original research -
Mass-spectrometric identification of anandamide and 2-arachidonoylglycerol in nematodes
Lehtonen M, Reisner K, Auriola S, Wong G, Callaway JC. 2008. Chemistry and biodiversity. 5: 2431-2441 A1 Journal article (refereed), original research -
Nicotine metabolism and urinary elimination in mouse: in vitro and in vivo
Raunio H, Pokela N, Puhakainen K, Rahnasto M, Mauriala T, Auriola S, Juvonen RO. 2008. Xenobiotica. 38: 34-47 A1 Journal article (refereed), original research -
Quantitative determination of underivatized polyamines by using isotope dilution RP-LC-ESI-MS/MS
Häkkinen MR, Keinänen TA, Vepsäläinen J, Khomutov AR, Alhonen L, Jänne J, Auriola S. 2008. Journal of pharmaceutical and biomedical analysis. 48: 414-421 A1 Journal article (refereed), original research -
The effect of cyclodextrins on chemical and physical stability of glucagon and characterization of glucagon/gamma-CD inclusion complexes
Matilainen L, Lambertsen Larsen K, Wimmer R, Keski-Rahkonen P, Auriola S, Järvinen T, Jarho P. 2008. Journal of pharmaceutical sciences. 97: 2720-2729 A1 Journal article (refereed), original research -
Analysis of underivatized polyamines by reversed phase liquid chromatography with electorspray tandem mass spectrometry
Häkkinen MR, Keinänen TA, Vepsäläinen J, Khomutov AR, Alhonen L, Jänne J, Auriola S. 2007. Journal of pharmaceutical and biomedical analysis. 45: 625-634 A1 Journal article (refereed), original research -
Deficient activity of mammalian prolyl oligopeptidase on the immunoactive peptide digestion in coeliac disease
Garcia-Horsman JA, Venäläinen JI, Lohi O, Auriola IS, Korponay-Szabo IR, Kaukinen K, Mäki M, Männistö PT. 2007. Scandinavian journal of gastroenterology. 42: 562-571 A1 Journal article (refereed), original research -
Determination of tamsulosin in human aqueous humor and serum by liquid chromatography - electrospray ionization tandem mass spectrometry
Keski-Rahkonen P, Pärssinen O, Leppänen E, Mauriala T, Lehtonen M, Auriola S. 2007. Journal of pharmaceutical and biomedical analysis. 43: 606-612 A1 Journal article (refereed), original research -
Effects of glucosamine sulfate on intracellular UDP-hexosamine and UDP-glucuronic acid levels in bovine primary chondrocytes
Qu C-J, Jauhianen M, Auriola S , Helminen Heikki J, Lammi MJ. 2007. Osteoarthritis and cartilage. 15: 773-779 A1 Journal article (refereed), original research -
Pyrrolidine dithiocarbamate activates akt and improves spatial learning in APP/PS1 mice without affecting beta-amyloid burden
Malm TM, Iivonen H, Goldsteins G, Keksa-Goldsteine V, Ahtoniemi T, Kanninen K, Salminen A, Auriola S, van Groen T, Tanila H, Koistinaho J. 2007. Journal of neuroscience. 27: 3712-3721 A1 Journal article (refereed), original research -
Quantitative determination of acetylcholine in microdialysis samples using liquid chromatography/atmospheric pressure spray ionization mass spectrometry
Keski-Rahkonen P, Lehtonen M, Ihalainen J, Sarajärvi T, Auriola S. 2007. Rapid communications in mass spectrometry. 21: 2933-2943 A1 Journal article (refereed), original research -
Zoledronic acid-induced IPP/ApppI production in vivo
Mönkkönen H, Ottewell PD, Kuokkanen J, Mönkkönen J, Auriola S, Holen I. 2007. Life sciences. 81: 1066-1070 A1 Journal article (refereed), original research -
A new endogenous ATP analog (ApppI) inhibits the mitochondrial adenine nucleotide translocase (ANT) and is responsible for the apoptosis induced by nitrogen-containing bisphosphonates
Mönkkönen H, Auriola S, Lehenkari P, Kellinsalmi M, Hassinen IE, Vepsäläinen J, Mönkkönen J. 2006. British journal of pharmacology. 147: 437-445 A1 Journal article (refereed), original research -
Drug adsorption to plastic containers and retention of drugs in cultured cells under in vitro conditions
Palmgrén JJ, Mönkkönen J, Korjamo T, Hassinen A, Auriola S. 2006. European journal of pharmaceutics and biopharmaceutics. 64: 369-378 A1 Journal article (refereed), original research -
In vitro evaluation of the effect of cyclodextrin complexation on pulmonary deposition of a peptide, cyclosporin A
Matilainen L, Järvinen K, Toropainen T, Näsi E, Auriola S, Järvinen T, Jarho P. 2006. International journal of pharmaceutics. 318: 41-48 A1 Journal article (refereed), original research -
Multivariate analysis of protein profiles of metal hyperaccumulator Thlaspi caerulescens accessions
Tuomainen MH, Nunan N, Lehesranta SJ, Tervahauta AI, Hassinen VH, Schat H, Koistinen KM, Auriola S, McNicol J, Kärenlampi SO. 2006. Proteomics. 6: 3696-3706 A1 Journal article (refereed), original research -
Analysis of bean (Phaseolus vulgaris L.) proteins affected by copper stress
Cuypers A, Koistinen KM, Kokko H, Kärenlampi S, Auriola S, Vangronsveld J. 2005. Journal of plant physiology. : 383-392 A1 Journal article (refereed), original research -
Comparison of tuber proteomes of potato varieties, landraces, and genetically modified lines
Lehesranta SJ, Davies HV, Shepherd LVT, Nunan N, McNicol JW, Auriola S, Koistinen KM, Suomalainen S, Kokko HI, Kärenlampi SO. 2005. Plant physiology. 138: 1690-1699 A1 Journal article (refereed), original research -
Isolation and characterization of yuremamine, a new phytoindole
Vepsäläinen JJ, Auriola S, Tukiainen M, Ropponen N, Callaway JC. 2005. Planta medica. 71: 1053-1057 A1 Journal article (refereed), original research -
Proteomic analysis of glial fibrillary acidic protein in Alzheimer¿s disease and aging brain
Korolainen MA, Auriola S, Nyman TA, Alafuzoff I, Pirttilä T, Korolainen MA, Pirttilä T. 2005. Neurobiology of disease. 20: 858-870 A1 Journal article (refereed), original research -
Quantitative determination of cholesterol, sitosterol, and sitostanol in cultured Caco-2 cells by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry
Palmgrén JJ, Töyräs A, Mauriala T, Mönkkönen J, Auriola S. 2005. Journal of chromatography b: analytical technologies in the biomedical and life sciences. 821: 144-152 A1 Journal article (refereed), original research -
Assessment of recombinant dog allergens Can f 1 and Can f 2 for the diagnosis of dog allergy
Saarelainen S, Taivainen A, Rytkönen-Nissinen M, Auriola S, Immonen A, Mäntyjärvi R, Rautiainen J, Kinnunen T, Virtanen T. 2004. Clinical and experimental allergy. 34: 1576-1582 A1 Journal article (refereed), original research -
Characterization of Caco-2 cell monolayer drug transport properties by cassette dosing using UV/fluorescence HPLC
Palmgrén J, Mönkkönen J, Jukkola E, Niva S, Auriola S. 2004. European journal of pharmaceutics and biopharmaceutics. 57: 319-328 A1 Journal article (refereed), original research -
Determination of long-chain fatty acid acyl-coenzyme A compounds using liquid chromatography-electrospray ionization tandem mass spectrometry
Mauriala T, Herzig KH, Heinonen M, Idziak J, Auriola S. 2004. Journal of chromatography b: analytical technologies in the biomedical and life sciences. 808: 263-268 A1 Journal article (refereed), original research -
Effects of triaryl phosphates on mouse and human nuclear receptors
Honkakoski P, Palvimo JJ, Penttilä L, Vepsäläinen J, Auriola S. 2004. Biochemical pharmacology. 67: 97-106 A1 Journal article (refereed), original research -
Glycosylation changes in Alzheimer's disease as revealed by a proteomic approach
Kanninen K, Goldsteins G, Auriola S, Alafuzoff I, Koistinaho J. 2004. Neuroscience letters. 367: 235-240 A1 Journal article (refereed), original research -
HPLC electrospray mass spectrometric characterization of trimeric building blocks for oligonucleotide synthesis
Mauriala T, Auriola S, Azhayev A, Kayushin A, Korosteleva M, Miroshnikov A. 2004. Journal of pharmaceutical and biomedical analysis. 34: 199-206 A1 Journal article (refereed), original research -
Partial amino acid sequence of a cellullase-like component with IgE-binding properties from stachybotrys chartarum
Kärkkäinen M, Raunio P, Rautiainen J, Auriola S, Hinke K, Pasanen A-L. 2004. International archives of allergy and immunology. 133: 136-144 A1 Journal article (refereed), original research -
Selective circular oligonucleotide probes improve detection of point mutations in DNA
Tennilä T, Ketomäki K, Penttinen P, Tengvall U, Azhayeva E, Auriola S, Lönnberg H, Azhayev A. 2004. Chemistry and biodiversity. 1: 609-625 A1 Journal article (refereed), original research -
The microglia-activating potential of thrombin
Hanisch U-K, van Rossum D, Xie Y, Gast K, Misselwitz R, Auriola S, Goldsteins G, Koistinaho J, Kettenmann H, Möller T. 2004. Journal of biological chemistry. 279: 51880-51887 A1 Journal article (refereed), original research -
Cellular uptake and metabolism of clodronate and its derivatives in Caco-2 cells: a possible correlation with bisphosphonate-induced gastrointestinal side-effects
Mönkkönen H, Törmälehto S, Asunmaa K, Niemi R, Auriola S, Vepsäläinen J, Mönkkönen J. 2003. European journal of pharmaceutical sciences. 19: 23-29 A1 Journal article (refereed), original research -
Characterization of antisense oligonucleotide-peptide conjugates with negative ionization electrospray mass spectrometry and liquid chromatography-mass spectrometry
Tengvall U, Auriola S, Antopolsky M, Azhayev A, Biegelman L. 2003. Journal of pharmaceutical and biomedical analysis. 32: 581-590 A1 Journal article (refereed), original research -
Liquid chromatography/atmospheric pressure ionization-mass spectrometry in drug metabolism studies
Kostiainen R, Kotiaho T, Kuuranne T, Auriola S. 2003. Journal of mass spectrometry. 38: 357-372 A1 Journal article (refereed), original research -
Paracellular and passive transcellular permeability in immortalized human corneal epithelial cell culture model
Toropainen E, Ranta V-P, Vellonen K-S, Palmgrén J, Talvitie A, Laavola M, Suhonen P, Hämäläinen KM, Auriola S, Urtti A. 2003. European journal of pharmaceutical sciences. 20: 99-106 A1 Journal article (refereed), original research -
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-induced accumulation of biliverdin and hepatic peliosis in rats
Niittynen M, Tuomisto JT, Auriola S, Pohjanvirta R, Syrjälä P, Simanainen U, Viluksela M, Tuomisto J. 2002. Toxicological sciences. 71: 112-123 A1 Journal article (refereed), original research -
Birch PR-10c is induced by factors causing oxidative stress but appears not to confer tolerance to these agents
Koistinen KM, Hassinen VH, Gynther PAM, Lehesranta SJ, Keinänen SI, Kokko HI, Oksanen EJ, Tervahauta AI, Auriola S, Kärenlampi SO. 2002. New phytologist. 155: 381-391 A1 Journal article (refereed), original research -
High-performance liquid chromatography-mass spectrometry and electron-capture dissociation tandem mass spectrometry of osteocalcin determination of gamma-carboxyglutamic acid residues
Niiranen H, Budnik BA, Zubarev RA, Auriola S, Lapinjoki S. 2002. Journal of chromatography a. 962: 95-103 A1 Journal article (refereed), original research -
Isolation and identification of Aspergillus fumigatus mycotoxins on growth medium and some building materials
Nieminen SM, Kärki R, Auriola S, Toivola M, Laatsch H, Laatikainen R, Hyvärinen A, Von Wright A. 2002. Applied and environmental microbiology. 68: 4871-4875 A1 Journal article (refereed), original research -
Liquid chromatographic-electrospray ionization mass spectrometric analysis of neutral and charged polyethylene glycols
Palmgrén JJ, Toropainen E, Auriola S, Urtti A. 2002. Journal of chromatography a. 976: 165-170 A1 Journal article (refereed), original research -
Removal of common Fusarium toxins in vitro by strains of Lactobacillus and Propionibacterium
El-Nezami HS, Chrevatidis A, Auriola S, Salminen S, Mykkänen H. 2002. Food additives and contaminants. 19: 680-686 A1 Journal article (refereed), original research -
Simultaneous determination of eight beta-blockers by gradient high-performance liquid chromatography with combined ultraviolet and fluorescence detection in corneal permeability studies in vitro
Ranta V-P, Toropainen E, Talvitie A, Auriola S, Urtti A. 2002. Journal of chromatography b: analytical technologies in the biomedical and life sciences. 772: 81-87 A1 Journal article (refereed), original research -
Stress-related RNase PR-10c is post-translationally modified by glutathione in birch
Koistinen KM, Kokko HI, Hassinen VH, Tervahauta AI, Auriola S, Kärenlampi SO. 2002. Plant cell and environment. 25: 707-715 A1 Journal article (refereed), original research -
The cellular uptake and metabolism of clodronate in RAW 264 macrophages
Mönkkönen H, Rogers MJ, Makkonen N, Niva S, Auriola S, Mönkkönen J. 2001. Pharmaceutical research. 18: 1550-1555 A1 Journal article (refereed), original research -
The molecular mechanism of action of the antiresorptive and antiinflammatory drug clodronate
Frith JC, Mönkkönen J, Auriola S, Mönkkönen H, Rogers MJ. 2001. Arthritis and rheumatism. 44: 2201-2210 A1 Journal article (refereed), original research -
Two new variants of the lipocalin allergen Bos d 2
Rautiainen J, Auriola S, Konttinen A, Virtanen T, Rytkönen-Nissinen M, Zeiler T, Mäntyjärvi R. 2001. Journal of chromatography b: analytical technologies in the biomedical and life sciences. 763: 91-98 A1 Journal article (refereed), original research -
Analysis of an adenine nucleotide-containing metabolite of clodronate using ion pair high-performance liquid chromatography-electrospray ionisation mass spectrometry
Mönkkönen H, Moilanen P, Mönkkönen J, Frith JC, Rogers MJ, Auriola S. 2000. Journal of chromatography b: analytical technologies in the biomedical and life sciences. 738: 395-403 A1 Journal article (refereed), original research -
Differential regulation of stress proteins by high hydrostatic pressure, heat shock, and unbalanced calcium homeostasis in chondrocytis cells
Elo MA, Sironen RK, Kaarniranta K, Auriola S, Helminen HJ, Lammi MJ. 2000. Journal of cellular biochemistry. 79: 610-619 A1 Journal article (refereed), original research -
Enzymatic and permeation barrier of [D-Ala2]-met-enkephalinamide in the anterior membranes of the albino rabbit eye
Hämäläinen KM, Ranta V-P, Auriola S, Urtti A. 2000. European journal of pharmaceutical sciences. 9: 265-270 A1 Journal article (refereed), original research -
Kinetic characteristics of norcocaine N-hydroxylation in mouse and human liver microsomes: involvement of CYP enzymes
Pellinen P, Kulmala L, Konttila J, Auriola S, Pasanen M, Juvonen R. 2000. Archives of toxicology. 74: 511-520 A1 Journal article (refereed), original research -
Analysis of adenine nucleotide containing metabolite of clodronate using ion pair HPLC-ESI-MS
Auriola S, Monkkonen H, Frith J, Rogers M, Monkkonen J. Teoksessa: (toim.) , 1999. The 47th ASMS Conference on Mass Spectrometry And Allied Topics. Proceedings. [CD-ROM]. s. . A4 Conference proceedings -
Antibioottiset peptidit
Toroskainen C, Auriola S. 1999. Dosis. 15: 12-22 A2 Review article, Literature review, Systematic review -
Effects of bisphosphonates on the inflammatory processes of activated macrophages
Mönkkönen J, Makkonen N, Rogers MJ, Frith JC, Auriola S. 1999. PHOSPHORUS, SULFUR, AND SILICON AND THE RELATED ELEMENTS. 144-146: 321-324 A1 Journal article (refereed), original research -
Farnesol and geranylgeraniol prevent activation of caspases by aminobisphosphonates: biochemical evidence for two distinct pharmacological classes of bisphosphonate drugs
Benford HL, Frith JC, Auriola S, Mönkkönen J, Rogers MJ. 1999. Molecular pharmacology. 56: 131-140 A1 Journal article (refereed), original research -
High-performance liquid chromatography-mass spectrometry of an osteocalcin derivative
Vähätalo H, Auriola S, Lapinjoki S. 1999. Journal of chromatography a. 846: 49-57 A1 Journal article (refereed), original research -
Mass spectrometric (HPLC/ESI-MS/MS) quantification of pyrimido[1,2-a]purin-10(3H)-one, a guanine adduct formed by reaction of malondialdehyde with DNA
Hakala K, Auriola S, Koivisto A, Lönnberg H. 1999. Journal of pharmaceutical and biomedical analysis. 21: 1053-1061 A1 Journal article (refereed), original research -
Molecular mechanisms of action of bisphosphonates
Rogers MJ, Frith JC, Luckman SP, Coxon FP, Benford HL, Mönkkönen J, Auriola S, Chilton KM, Russell RGG. 1999. Bone. 24: 73S-79S A1 Journal article (refereed), original research -
Peptide-oligonucleotide phosphorothioate conjugates with membrane translocation and nuclear localization properties
Antopolsky M, Azhayeva E, Tengvall U, Auriola S, Jääskeläinen I, Rönkkö S, Honkakoski P, Urtti A, Lönnberg H, Azhayev A. 1999. Bioconjugate chemistry. 10: 598-606 A1 Journal article (refereed), original research -
Enhancement of sample loadings for the analysis of oligosaccharides isolated from pseudomonas aeruginosa using transient isotachophoresis and capillary zone electrophoresis - electrospray - mass spectrometry
Auriola S, Thibault P, Sadovskaya I, Altman E. 1998. Electrophoresis. 19: 2665-2676 A1 Journal article (refereed), original research -
Gradient high-performance liquid chromatographic analysis of enkephalin peptides, their metabolites, and enzyme inhibitors using combined ultraviolet and electrochemical detection. II. Application to ocular permeability studies in vitro
Ranta V-P, Hämäläinen KM, Auriola S, Urtti A. 1998. Journal of chromatography b: analytical technologies in the biomedical and life sciences. 709: 1-10 A1 Journal article (refereed), original research -
High-performance liquid chromatography with electrospray ionization mass spectrometry and diode array ultraviolet detection in the identification of flavonol aglycones and glycosides in berries
Häkkinen S, Auriola S. 1998. Journal of chromatography a. 829: 91-100 A1 Journal article (refereed), original research -
Molecular and crystal properties of Bos d 2, an allergenic protein of the lipocalin family
Rautiainen J, Auriola S, Rouvinen J, Kauppinen J, Zeiler T, Novikov D, Virtanen T, Mäntyjärvi RA. 1998. Biochemical and biophysical research communications. 247: 746-750 A1 Journal article (refereed), original research -
New building blocks for the preparation of branched oligonucleotides
Azhayev A, Auriola S, Hovinen J. 1998. Nucleosides nucleotides and nucleic acids. 17: 1527-1537 A1 Journal article (refereed), original research -
PR-10 protein is induced by copper stress in roots and leaves of a Cu/Zn tolerant clone of birch, Betula pendula
Utriainen M, Kokko H, Auriola S, Sarrazin O, Kärenlampi S. 1998. Plant cell and environment. 21: 821-828 A1 Journal article (refereed), original research -
Analysis of oligonucleotides with capillary electrophoresis electrospray mass spectrometry
Auriola S, Thibault P, Koivuniemi A, Jääskeläinen I, Urtti A. Teoksessa: (toim.) , 1997. The 45th ASMS Conference on Mass Spectrometry and Allied Topics. Proceedings.. s. 651. A4 Conference proceedings -
Characterization of paracellular and aqueous penetration routes in cornea, conjunctiva, and sclera
Hämäläinen KM, Kananen K, Auriola S, Kontturi K, Urtti A. 1997. Investigative ophthalmology and visual science. 38: 627-634 A1 Journal article (refereed), original research -
Estimation of pore size and pore density of biomembranes from permeability measurements of polyethylene glycols using an effusion-like approach
Hämäläinen KM, Kontturi K, Auriola S, Murtomäki L, Urtti A. 1997. Journal of controlled release. 49: 97-104 A1 Journal article (refereed), original research -
Gradient high-performance liquid chromatographic analysis of enkephalin peptides, their metabolites and enzyme inhibitors using combined ultraviolet and electrochemical detection. I. Optimization of separation and detection
Ranta V-P, Urtti A, Auriola S. 1997. Journal of chromatography a. 766: 85-97 A1 Journal article (refereed), original research -
Identification of adenine nucleotide-containing metabolites of bisphosphonate drugs using ion-pair liquid chromatography-electrospray mass spectrometry
Auriola S, Frith J, Rogers MJ, Koivuniemi A, Mönkkönen J. 1997. Journal of chromatography b: analytical technologies in the biomedical and life sciences. 704: 187-195 A1 Journal article (refereed), original research -
Inhibitory properties of double helix forming circular oligonucleotides
Azhayeva E, Azhayev A, Auriola S, Tengvall U, Urtti A, Lönnberg H. 1997. Nucleic acids research. 25: 4954-4961 A1 Journal article (refereed), original research -
Analysis of oligonucleotides by on-column transient capillary isotachophoresis and capillary electrophoresis in poly(ethylene glycol)-filled columns
Auriola S, Jääskeläinen I, Regina M, Urtti A. 1996. Analytical chemistry. 68: 3907-3911 A1 Journal article (refereed), original research -
Determination of urinary 2-mercaptobenzothiazole (2-MBT), the main metabolite of 2-(thiocyanomethylthio)benzothiazole (TCMTB) in humans and rats
Manninen A, Auriola S, Vartiainen M, Liesivuori J, Turunen T, Pasanen M. 1996. Archives of toxicology. 70: 579-584 A1 Journal article (refereed), original research -
CE-MS and MS-MS analyses of lipopolysaccharides from p.aeruginosa
Auriola S, Thibault P, Sadovskaya I, Masoud H, Altman E, Richards JC. Teoksessa: (toim.) , 1995. Proceedings the 43rd ASMS Conference on Mass Spectrometry and Allied Topics. s. 977. A4 Conference proceedings -
Glucose metabolism in the developing cerebral cortex as detected by 1H {13C} nuclear magnetic resonance spectroscopy ex vivo
Pirttilä T-RM, Auriola SOK, Kauppinen R. 1995. Journal of neurochemistry. 64: 417-423 A1 Journal article (refereed), original research -
Compartmentation of cerebral glutamate in situ as detected by 1H/13C n.m.r
Kauppinen RA, Pirttilä T-RM, Auriola SOK, Williams SR. 1994. Biochemical journal. 298: 121-127 A1 Journal article (refereed), original research -
Mass spectrometric characterization of a series of adenosylated peptides acting as bisubstrate analogs of protein kinases
Gibson BW, Medzihradszky D, Hines WM, Auriola S, Kenyon GL. 1994. Journal of the american society for mass spectrometry. 5: 443-451 A1 Journal article (refereed), original research