Niskanen Group: Regulatory mechanisms of steroid receptors

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Synthetic glucocorticoids (GCs) are potent anti-inflammatory drugs that are used to treat various inflammatory diseases, including asthma and rheumatoid arthritis. Prolonged medical use of GCs is however hindered by the adverse side effects that can lead to e.g. diabetes and osteoporosis. GCs function by activating a transcription factor, GC receptor, which induces and represses genes. Anti-inflammatory actions of GCs are result from repression of inflammatory genes, while the side effects arise from activation of metabolic genes. While the mechanisms of gene induction in GC signaling are relatively well characterized, those of gene repression are not.
That’s where we step in! Our aim is to understand mechanisms of GC signaling by and omics data layers and modeling.

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