Regulatory mechanisms of steroid receptors - Niskanen lab
Leaders
Our aim is to understand how coregulators influence transcriptional regulation. As models, we use cortisol and inflammatory signaling pathways, that can be induced on demand.
Synthetic glucocorticoids (GCs) are potent anti-inflammatory drugs that are used to treat various inflammatory diseases, including asthma and rheumatoid arthritis. Prolonged medical use of GCs is however hindered by the adverse side effects that can lead to e.g. diabetes and osteoporosis. GCs function by activating a transcription factor, GC receptor, which induces and represses genes. Anti-inflammatory actions of GCs are result from repression of inflammatory genes, while the side effects arise from activation of metabolic genes. While the mechanisms of gene induction in GC signaling are relatively well characterized, those of gene repression are not.
Cooperation
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Professor
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Academy Research Fellow
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Professor , Biomedicine
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Academy Research Fellow
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University Researcher, Adjunct Professor in Cancer Biology
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Academy of Finland Postdoctoral Researcher
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Academy Research Fellow, Assistant Professor of Health Bioinformatics (tenure track)
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Assistant Professor in Next Generation Gene Therapy (Tenure track)
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Grégoire Stik
Group leader
Keywords
Publications
20 items-
Chromatin accessibility and pioneer factor FOXA1 restrict glucocorticoid receptor action in prostate cancer
Helminen, Laura; Huttunen, Jasmin; Tulonen, Melina; Aaltonen, Niina; Niskanen, Einari A; Palvimo, Jorma J; Paakinaho, Ville. 2023. Nucleic acids research. 2024; 52: 625-642 -
Complementary analysis of proteome‐wide proteomics reveals changes in RNA binding protein‐profiles during prostate cancer progression
Aikio, Erika; Koivukoski, Sonja; Kallio, Elina; Sadeesh, Nithin; Niskanen, Einari A; Latonen, Leena. 2023. Cancer reports. 6: -
Genetic variation is a key determinant of chromatin accessibility and drives differences in the regulatory landscape of C57BL/6J and 129S1/SvImJ mice
Mononen, Juho; Taipale, Mari; Malinen, Marjo; Velidendla, Bharadwaja; Niskanen, Einari; Levonen, Anna-Liisa; Ruotsalainen, Anna-Kaisa; Heikkinen, Sami. 2023. Nucleic acids research. 2024; 52: 2904-2923 -
International Online Team-Based Learning in Higher Education of Biomedicine - Evaluation by Learning Analytics
Mairinoja, Laura; López-Pernas, Sonsoles; Elmoazen, Ramy; Niskanen, Einari A.; Kuningas, Tiina; Wärri, Anni; Saqr, Mohammed; Strauss, Leena. Teoksessa: Elmoazen, Ramy; López-Pernas, Sonsoles; Misiejuk, Kamila; Khalil, Mohammad; Wasson, Barbara; Saqr, Mohammed(toim.) , 2023. Proceedings of the Technology-Enhanced Learning in Laboratories Workshop (TELL 2023). s. 49-60. -
Parvovirus nonstructural protein 2 interacts with chromatin-regulating cellular proteins
Mattola, Salla; Salokas, Kari; Aho, Vesa; Mäntylä, Elina; Salminen, Sami; Hakanen, Satu; Niskanen, Einari A.; Svirskaite, Julija; Ihalainen, Teemu O.; Airenne, Kari J.; Kaikkonen-Määttä, Minna; Parrish, Colin R.; Varjosalo, Markku; Vihinen-Ranta, Maija. 2022. PLoS pathogens. 18: -
BCOR modulates transcriptional activity of a subset of glucocorticoid receptor target genes involved in cell growth and mobility
Manjur, ABMK; Lempiäinen, JK; Malinen, M; Varjosalo, M; Palvimo, JJ; Niskanen, EA. 2021. Journal of steroid biochemistry and molecular biology. 210: 105873 -
Chromatin-directed proteomics-identified network of endogenous androgen receptor in prostate cancer cells
Launonen, Kaisa-Mari; Paakinaho, Ville; Sigismondo, Gianluca; Malinen, Marjo; Sironen, Reijo; Hartikainen, Jaana M; Laakso, Hanna; Visakorpi, Tapio; Krijgsveld, Jeroen; Niskanen, Einari A; Palvimo, Jorma J. 2021. Oncogene. 40: 4567-4579 -
SUMOylation regulates the protein network and chromatin accessibility at glucocorticoid receptor-binding sites
Paakinaho, Ville; Lempiäinen, Joanna K; Sigismondo, Gianluca; Niskanen, Einari A; Malinen, Marjo; Jääskeläinen, Tiina; Varjosalo, Markku; Krijgsveld, Jeroen; Palvimo, Jorma J. 2021. Nucleic acids research. 49: 1951-1971 -
Stress-induced nuclear condensation of NELF drives transcriptional downregulation
Rawat, Prashant; Boehning, Marc; Hummel, Barbara; Aprile-Garcia, Fernando; Pandit, Anwit S; Eisenhardt, Nathalie; Khavaran, Ashkan; Niskanen, Einari; Vos, Seychelle M; Palvimo, Jorma J; Pichler, Andrea; Cramer, Patrick; Sawarkar, Ritwick. 2021. Molecular cell. 81: 1013-1026 -
BCOR-coupled H2A monoubiquitination represses a subset of androgen receptor target genes regulating prostate cancer proliferation
Lempiäinen, JK; Manjur, ABMK; Malinen, M; Ketola, K; Niskanen, EA; Palvimo, JJ. 2020. Oncogene. 39: 2391-2407