Annakaisa Haapasalo Group (Molecular Neurodegeneration)

01.06.2015 -

Research group

Our research focus lies in the genetic background and molecular mechanisms underpinning neurodegenerative diseases, especially frontotemporal dementia (FTD). We utilize a variety of in vitro and in vivo model systems and patient-derived cells, clinical samples and data. We are especially interested in the function and dysfunction of neuronal synapses, cell metabolism, cellular degradation mechanisms, such as autophagy and proteasomes, as well as glial cells that mediate neuroinflammation. In our translational studies, we closely collaborate with clinical researchers to identify novel biomarkers, diagnostic tools, and therapeutic targets.

We are part of the Finnish FinFTD research network, which brings together Finnish basic and clinical FTD researchers. We also belong to the UEF Neuroscience Research Community (NSciRC).

*** Read more from links in the list of publications about our most recent studies on e.g., the effects of C9orf72 repeat expansion on synapses, a new genetic marker for the C9orf72 repeat expansion, blood-based GFAP as a biomarker in FTD, and utilization of FTD patients' skin fibroblasts in disease mechanistic studies and their potential in biomarker and drug research.

Funder(s)

Main funder

Academy of Finland

Annakaisa Haapasalo Group (Molecular Neurodegeneration) funder logo Annakaisa Haapasalo Group (Molecular Neurodegeneration) funder logo

Other funders

EU-JPND H2020

Sigrid Jusélius Foundation

Group description

Introducing image of the groupAnnakaisa Haapasalo Group (Molecular Neurodegeneration)

Molecular Neurodegeneration research group

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Keywords

Time period

01.06.2015 -

Group members - UEF

Collaboration with UEF research groups

Cooperation partners

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Publications