
Leaders
Group description
Our group studies the molecular mechanisms of neurodegeneration involved in the pathogenesis of frontotemporal dementia (FTD). FTD is the most common cause of dementia in under 60-year-olds. We especially focus on the genetic form of FTD caused by the hexanucleotide repeat expansion in the C9orf72 gene, because it is exceptionally common in Finnish FTD patients. We are interested in molecular pathogenetic and functional changes in neurons and microglia derived from FTD patients. We also aim to identify novel biomarkers to help differential diagnostics of different forms of FTD. We are active participants of the Finnish FTD Research Network, FinFTD, and we closely collaborate with FTD clinical researchers with the goal of translating our findings for the benefit of the patients.
Follow us in Twitter @HaapasaloLab.
Projects
Cooperation
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Finnish FTD Research Network (FinFTD) 01.05.2016 -
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AIVI Stem Cell Center
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Bioinformatics Center
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Biomarkers for Neurological Disorders 08.06.2004 -
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Cell and Tissue Imaging Unit
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Frontotemporal Lobar Degeneration and Early Onset Dementia 01.01.2022 -
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GenomMed 01.04.2018 - 31.12.2022
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Molecular Genetics of Alzheimer's Disease 01.01.2022 -
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Neuroinflammation research group
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Neurobiology of Memory 12.11.2022 -
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UEF Neurodegeneration - Myohanen Lab 02.08.2021 -
Keywords
Leaders
Post-doctoral Researchers
Doctoral Researchers
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Nadine Huber
Doctoral ResearcherFaculty of Health Sciences, A.I. Virtanen Institute for Molecular Sciences -
Tomi Hietanen
Early Stage Researcher- -
Elena Ppali
Early Stage Researcher
Previous group members
Publications
24 items-
A Novel Genetic Marker for the C9orf72 Repeat Expansion in the Finnish Population
Rostalski, H; Korhonen, V; Kuulasmaa, T; Solje, E; Krüger, J; Gen, F; Kaivola, K; Eide, PK; Lambert, JC; Julkunen, V; Tienari, PJ; Remes, AM; Leinonen, V; Hiltunen, M; Haapasalo, A. Journal of Alzheimer's disease 83 3: 1325-1332. 2021 -
Alzheimerin taudin uudet riskigeenit - keskiössä mikrogliasolut
Martiskainen, Henna; Takalo, Mari; Konttinen, Henna; Malm, Tarja; Haapasalo, Annakaisa; Leinonen, Ville; Hiltunen, Mikko. Duodecim 137 13: 1375- 1382. 2021 -
C9orf72 hexanucleotide repeat expansion leads to altered neuronal and dendritic spine morphology and synaptic dysfunction
Huber, Nadine; Hoffmann, Dorit; Giniatullina, Raisa; Rostalski, Hannah; Leskelä, Stina; Takalo, Mari; Natunen, Teemu; Solje, Eino; Remes, Anne M.; Giniatullin, Rashid; Hiltunen, Mikko; Haapasalo, Annakaisa. Neurobiology of disease 2022; 162: 105584. 2021 -
Common variants in Alzheimer's disease and risk stratification by polygenic risk scores
de Rojas, I; Moreno-Grau, S; Tesi, N; Grenier-Boley, B; Andrade, V; Jansen, IE; Pedersen, NL; Stringa, N; Zettergren, A; Hernández, I; Montrreal, L; Antúnez, C; Antonell, A; Tankard, RM; Bis, JC; Sims, R; Bellenguez, C; Quintela, I; González-Perez, A; Calero, M; et al; [incl. Haapasalo, A; Soininen, H; Lehtisalo, J; Kivipelto, M; Kuulasmaa, T; Hiltunen, M]. Nature communications 12 1: 3417. 2021 -
Deficient neurotransmitter systems and synaptic function in frontotemporal lobar degeneration-Insights into disease mechanisms and current therapeutic approaches
Huber, Nadine; Korhonen, Sonja; Hoffmann, Dorit; Leskelä, Stina; Rostalski, Hannah; Remes, Anne M.; Honkakoski, Paavo; Solje, Eino; Haapasalo, Annakaisa. Molecular psychiatry Published online: 19 November 2021: 1 - 10. 2021 -
Expression of C9orf72 hexanucleotide repeat expansion leads to formation of RNA foci and dipeptide repeat proteins but does not influence autophagy or proteasomal function in neuronal cells
Leskelä, Stina; Huber, Nadine; Hoffmann, Dorit; Rostalski, Hannah; Remes, Anne M; Takalo, Mari; Hiltunen, Mikko; Haapasalo, Annakaisa. Biochimica et biophysica acta: molecular cell research 1868 7: 119021. 2021 -
FTLD Patient-Derived Fibroblasts Show Defective Mitochondrial Function and Accumulation of p62
Leskelä, S; Hoffmann, D; Rostalski, H; Huber, N; Wittrahm, R; Hartikainen, P; Korhonen, V; Leinonen, V; Hiltunen, M; Solje, E; Remes, AM; Haapasalo, A. Molecular neurobiology 58 11: 5438-5458. 2021 -
GFAP as a biomarker in frontotemporal dementia and primary psychiatric disorders: diagnostic and prognostic performance
Katisko, Kasper; Cajanus, Antti; Huber, Nadine; Jääskeläinen, Olli; Kokkola, Tarja; Kärkkäinen, Virve; Rostalski, Hannah; Hartikainen, Paivi; Koivisto, Anne M; Hannonen, Sanna; Lehtola, Juha-Matti; Korhonen, Ville E; Helisalmi, Seppo; Koivumaa-Honkanen, Heli; Herukka, Sanna-Kaisa; Remes, Anne M; Solje, Eino; Haapasalo, Annakaisa. Journal of neurology neurosurgery and psychiatry 92 12: 1305-1312. 2021 -
Otsa-ohimolohkorappeumat - miten tunnistan ja hoidan?
Krüger, Johanna; Katisko, Kasper; Suhonen, Noora-Maria; Haapasalo, Annakaisa; Remes, Anne M; Solje, Eino. Duodecim 137 21: 2307-2316. 2021 -
BV-2 Microglial Cells Overexpressing C9orf72 Hexanucleotide Repeat Expansion Produce DPR Proteins and Show Normal Functionality but No RNA Foci
Rostalski, Hannah; Hietanen, Tomi; Leskelä, Stina; Behánová, Andrea; Abdollahzadeh, Ali; Wittrahm, Rebekka; Mäkinen, Petra; Huber, Nadine; Hoffmann, Dorit; Solje, Eino; Remes, Anne M; Natunen, Teemu; Takalo, Mari; Tohka, Jussi; Hiltunen, Mikko; Haapasalo, Annakaisa. Frontiers in neurology 11: 550140. 2020